BibTex RIS Cite

Advanced oxidation protein products as an oxidative stress marker in allergic rhinitis

Year 2009, Volume: 19 Issue: 6, 279 - 284, 12.12.2009

Abstract

Objectives: This study was designed to compare the levels of dityrosine-containing protein cross-link products, also known as advanced oxidation protein products AOPP ; in patients with allergic rhinitis with those in healthy individuals considering the fact that AOPP has the potential to be a marker of oxidative stress specific to proteins in mammalian systems. Patients and Methods: This study was performed on 40 patients 18 males, 22 females; mean age 29 years; range 10 to 53 years with allergic rhinitis admitted to our clinic between December 2008 and January 2009 and on 40 healthy volunteers 16 males, 24 females; mean age 31 years; range 13 to 48 years . Skin prick test was performed to establish a diagnosis of allergic rhinitis in patients with major symptoms and allergic sensitization was also supported with serum IgE levels. Blood samples were obtained and examined in all patients to determine AOPP. Results: Serum AOPP levels were significantly higher in patients with allergic rhinitis 169.0±14.2 μmol/L compared to controls 43.9±3.5 μmol/L; p<0.001 . In addition, mean serum IgE levels of patients with allergic rhinitis 308.2±38.5 IU/ml were found to support the presence of allergic sensitization. Conclusion: Determining the levels of serum AOPP, a well-known marker of protein oxidation, appears to be a useful method in determining the role of oxidative stress in the etiopathogenesis of allergic rhinitis.

References

  • Asher MI, Montefort S, Björkstén B, Lai CK, Strachan DP, Weiland SK, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinocon- junctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 2006;368:733-43.
  • Bowler RP, Crapo JD. Oxidative stress in allergic respira- tory diseases. J Allergy Clin Immunol 2002;110:349-56.
  • Kompauer I, Heinrich J, Wolfram G, Linseisen J. Association of carotenoids, tocopherols and vitamin C in plasma with allergic rhinitis and allergic sensitisa- tion in adults. Public Health Nutr 2006;9:472-9.
  • Witko-Sarsat V, Friedlander M, Capeillère-Blandin C, Nguyen-Khoa T, Nguyen AT, Zingraff J, et al. Advanced oxidation protein products as a novel marker of oxida- tive stress in uremia. Kidney Int 1996;49:1304-13.
  • Vissers MC, Winterbourn CC. Oxidative damage to fibronectin. I. The effects of the neutrophil myeloper- oxidase system and HOCl. Arch Biochem Biophys 1991;285:53-9.
  • Wagner JG, Jiang Q, Harkema JR, Illek B, Patel DD, Ames BN, et al. Ozone enhancement of lower airway allergic inflammation is prevented by gamma-tocoph- erol. Free Radic Biol Med 2007;43:1176-88.
  • Matés JM, Segura JM, Pérez-Gómez C, Rosado R, Olalla L, Blanca M, et al. Antioxidant enzymatic activities in human blood cells after an allergic reaction to pollen or house dust mite. Blood Cells Mol Dis 1999;25:103-9.
  • Halliwell B, Gutteridge JMC. Free radicals, ageing, and disease. In: Halliwell B, Gutteridge JMC, editors. 2nd ed. Free radicals in biology and medicine. Oxford: Clarendon Press; 1996. p. 422-37.
  • Hanazawa T, Kharitonov SA, Barnes PJ. Increased nitro- tyrosine in exhaled breath condensate of patients with asthma. Am J Respir Crit Care Med 2000;162:1273-6.
  • Wu W, Samoszuk MK, Comhair SA, Thomassen MJ, Farver CF, Dweik RA, et al. Eosinophils generate bro- minating oxidants in allergen-induced asthma. J Clin Invest 2000;105:1455-63.
  • Emelyanov A, Fedoseev G, Abulimity A, Rudinski K, Fedoulov A, Karabanov A, et al. Elevated concen- trations of exhaled hydrogen peroxide in asthmatic patients. Chest 2001;120:1136-9.
  • Ichinose M, Sugiura H, Yamagata S, Koarai A, Shirato K. Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways. Am J Respir Crit Care Med 2000;162:701-6.
  • Ganas K, Loukides S, Papatheodorou G, Panagou P, Kalogeropoulos N. Total nitrite/nitrate in expired breath condensate of patients with asthma. Respir Med 2001;95:649-54.
  • Ogasawara H, Yoshimura S, Kumoi T. Hydrogen per- oxide generation by eosinophils in allergic rhinitis. Auris Nasus Larynx 1991;18:133-43.
  • Iijima MK, Kobayashi T, Kamada H, Shimojo N. Exposure to ozone aggravates nasal allergy-like symp- toms in guinea pigs. Toxicol Lett 2001;123:77-85.
  • Riediker M, Monn C, Koller T, Stahel WA, Wüthrich B. Air pollutants enhance rhinoconjunctivitis symptoms in pollen-allergic individuals. Ann Allergy Asthma Immunol 2001;87:311-8.
  • Briganti S, Cristaudo A, D’Argento V, Cassano N, Turbino L, Guarrera M, et al. Oxidative stress in physi- cal urticarias. Clin Exp Dermatol 2001;26:284-8.
  • Niewinski P, Orzechowska-Juzwenko K, Patkowski J, Wolanczyk-Medrala A, Nittner-Marszalska M, Rzemislawska Z. Oxidation phenotype as a risk factor for development of allergic diseases. Pol Arch Med Wewn 1999;101:23-7. [Abstract]
  • Dean RT, Fu S, Stocker R, Davies MJ. Biochemistry and pathology of radical-mediated protein oxidation. Biochem J 1997;324:1-18.
  • Davies MJ, Fu S, Wang H, Dean RT. Stable markers of oxidant damage to proteins and their application in the study of human disease. Free Radic Biol Med 1999; 27:1151-63.
  • Ezeamuzie CI, Al-Hage M. Effects of some anti-asthma drugs on human eosinophil superoxide anions release and degranulation. Int Arch Allergy Immunol 1998; 115:162-8.
  • Tsai KJ, Hung IJ, Chow CK, Stern A, Chao SS, Chiu DT. Impaired production of nitric oxide, superoxide, and hydrogen peroxide in glucose 6-phosphate-dehydroge- nase-deficient granulocytes. FEBS Lett 1998;436:411-4.
  • Misso NL, Brooks-Wildhaber J, Ray S, Vally H, Thompson PJ. Plasma concentrations of dietary and nondietary antioxidants are low in severe asthma. Eur Respir J 2005;26:257-64.
  • Patel BD, Welch AA, Bingham SA, Luben RN, Day NE, Khaw KT, et al. Dietary antioxidants and asthma in adults. Thorax 2006;61:388-93.
  • Davies KJ. Protein damage and degradation by oxy- gen radicals. I. general aspects. J Biol Chem 1987; 262:9895-901.
  • Witko-Sarsat V, Friedlander M, Nguyen Khoa T, Capeillère-Blandin C, Nguyen AT, Canteloup S, et al. Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure. J Immunol 1998;161:2524-32.
  • Massy ZA, Nguyen-Khoa T. Oxidative stress and chronic renal failure: markers and management. J Nephrol 2002;15:336-41.
  • Akbay E, Arbağ H, Uyar Y, Oztürk K. Oxidative stress and antioxidant factors in pathophysiology of allergic rhinitis. [Article in Turkish] Kulak Burun Bogaz Ihtis Derg 2007;17:189-96.

Alerjik rinitte oksidatif stres göstergesi olarak ileri oksidasyon protein ürünleri

Year 2009, Volume: 19 Issue: 6, 279 - 284, 12.12.2009

Abstract

Amaç: Bu çalışma memeli sistemlerde proteinlere özgü oksidatif stres varlığının bir göstergesi olma potansiyeline dayanarak, alerjik rinitli hastaların plazmalarında ileri oksidasyon protein ürünleri İOPÜ olarak da bilinen ditirozin içerikli protein çapraz bağ ürünleri düzeyinin sağlıklı bireylerle karşılaştırılması amacıyla tasarlandı.Hastalar ve Yöntemler: Bu çalışma Aralık 2008 ile Ocak 2009 tarihleri arasında kliniğimize başvuran ve alerjik rinit tanısı konan 40 hasta 18 erkek, 22 kadın; ort. yaş 29 yıl; dağılım 10-53 yıl ve sağlıklı 40 gönüllü 16 erkek, 24 kadın; ort. yaş 31 yıl; dağılım 13-48 yıl ile gerçekleştirildi. Majör semptomları olan hastalara deri prik testi yapılarak alerjik rinit tanısı kondu ve alerjik sensitizasyon serum IgE düzeyleri ile de desteklendi. İleri oksidasyon protein ürünlerinin tespiti için tüm hastalardan kan örnekleri alındı ve incelendi.Bulgular: Serum İOPÜ düzeyleri alerjik rinitli hastalarda 169.0±14.2 μmol/L kontrol grubuna göre anlamlı şekilde daha yüksek bulundu 43.9±3.5 μmol/L; p

References

  • Asher MI, Montefort S, Björkstén B, Lai CK, Strachan DP, Weiland SK, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinocon- junctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 2006;368:733-43.
  • Bowler RP, Crapo JD. Oxidative stress in allergic respira- tory diseases. J Allergy Clin Immunol 2002;110:349-56.
  • Kompauer I, Heinrich J, Wolfram G, Linseisen J. Association of carotenoids, tocopherols and vitamin C in plasma with allergic rhinitis and allergic sensitisa- tion in adults. Public Health Nutr 2006;9:472-9.
  • Witko-Sarsat V, Friedlander M, Capeillère-Blandin C, Nguyen-Khoa T, Nguyen AT, Zingraff J, et al. Advanced oxidation protein products as a novel marker of oxida- tive stress in uremia. Kidney Int 1996;49:1304-13.
  • Vissers MC, Winterbourn CC. Oxidative damage to fibronectin. I. The effects of the neutrophil myeloper- oxidase system and HOCl. Arch Biochem Biophys 1991;285:53-9.
  • Wagner JG, Jiang Q, Harkema JR, Illek B, Patel DD, Ames BN, et al. Ozone enhancement of lower airway allergic inflammation is prevented by gamma-tocoph- erol. Free Radic Biol Med 2007;43:1176-88.
  • Matés JM, Segura JM, Pérez-Gómez C, Rosado R, Olalla L, Blanca M, et al. Antioxidant enzymatic activities in human blood cells after an allergic reaction to pollen or house dust mite. Blood Cells Mol Dis 1999;25:103-9.
  • Halliwell B, Gutteridge JMC. Free radicals, ageing, and disease. In: Halliwell B, Gutteridge JMC, editors. 2nd ed. Free radicals in biology and medicine. Oxford: Clarendon Press; 1996. p. 422-37.
  • Hanazawa T, Kharitonov SA, Barnes PJ. Increased nitro- tyrosine in exhaled breath condensate of patients with asthma. Am J Respir Crit Care Med 2000;162:1273-6.
  • Wu W, Samoszuk MK, Comhair SA, Thomassen MJ, Farver CF, Dweik RA, et al. Eosinophils generate bro- minating oxidants in allergen-induced asthma. J Clin Invest 2000;105:1455-63.
  • Emelyanov A, Fedoseev G, Abulimity A, Rudinski K, Fedoulov A, Karabanov A, et al. Elevated concen- trations of exhaled hydrogen peroxide in asthmatic patients. Chest 2001;120:1136-9.
  • Ichinose M, Sugiura H, Yamagata S, Koarai A, Shirato K. Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways. Am J Respir Crit Care Med 2000;162:701-6.
  • Ganas K, Loukides S, Papatheodorou G, Panagou P, Kalogeropoulos N. Total nitrite/nitrate in expired breath condensate of patients with asthma. Respir Med 2001;95:649-54.
  • Ogasawara H, Yoshimura S, Kumoi T. Hydrogen per- oxide generation by eosinophils in allergic rhinitis. Auris Nasus Larynx 1991;18:133-43.
  • Iijima MK, Kobayashi T, Kamada H, Shimojo N. Exposure to ozone aggravates nasal allergy-like symp- toms in guinea pigs. Toxicol Lett 2001;123:77-85.
  • Riediker M, Monn C, Koller T, Stahel WA, Wüthrich B. Air pollutants enhance rhinoconjunctivitis symptoms in pollen-allergic individuals. Ann Allergy Asthma Immunol 2001;87:311-8.
  • Briganti S, Cristaudo A, D’Argento V, Cassano N, Turbino L, Guarrera M, et al. Oxidative stress in physi- cal urticarias. Clin Exp Dermatol 2001;26:284-8.
  • Niewinski P, Orzechowska-Juzwenko K, Patkowski J, Wolanczyk-Medrala A, Nittner-Marszalska M, Rzemislawska Z. Oxidation phenotype as a risk factor for development of allergic diseases. Pol Arch Med Wewn 1999;101:23-7. [Abstract]
  • Dean RT, Fu S, Stocker R, Davies MJ. Biochemistry and pathology of radical-mediated protein oxidation. Biochem J 1997;324:1-18.
  • Davies MJ, Fu S, Wang H, Dean RT. Stable markers of oxidant damage to proteins and their application in the study of human disease. Free Radic Biol Med 1999; 27:1151-63.
  • Ezeamuzie CI, Al-Hage M. Effects of some anti-asthma drugs on human eosinophil superoxide anions release and degranulation. Int Arch Allergy Immunol 1998; 115:162-8.
  • Tsai KJ, Hung IJ, Chow CK, Stern A, Chao SS, Chiu DT. Impaired production of nitric oxide, superoxide, and hydrogen peroxide in glucose 6-phosphate-dehydroge- nase-deficient granulocytes. FEBS Lett 1998;436:411-4.
  • Misso NL, Brooks-Wildhaber J, Ray S, Vally H, Thompson PJ. Plasma concentrations of dietary and nondietary antioxidants are low in severe asthma. Eur Respir J 2005;26:257-64.
  • Patel BD, Welch AA, Bingham SA, Luben RN, Day NE, Khaw KT, et al. Dietary antioxidants and asthma in adults. Thorax 2006;61:388-93.
  • Davies KJ. Protein damage and degradation by oxy- gen radicals. I. general aspects. J Biol Chem 1987; 262:9895-901.
  • Witko-Sarsat V, Friedlander M, Nguyen Khoa T, Capeillère-Blandin C, Nguyen AT, Canteloup S, et al. Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure. J Immunol 1998;161:2524-32.
  • Massy ZA, Nguyen-Khoa T. Oxidative stress and chronic renal failure: markers and management. J Nephrol 2002;15:336-41.
  • Akbay E, Arbağ H, Uyar Y, Oztürk K. Oxidative stress and antioxidant factors in pathophysiology of allergic rhinitis. [Article in Turkish] Kulak Burun Bogaz Ihtis Derg 2007;17:189-96.
There are 28 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Fadlullah Aksoy This is me

Hasan Demirhan This is me

Bayram Veyseller This is me

Yavuz Selim Yıldırım This is me

Orhan Özturan This is me

Filiz Basınoğlu This is me

Publication Date December 12, 2009
Published in Issue Year 2009 Volume: 19 Issue: 6

Cite

APA Aksoy, F., Demirhan, H., Veyseller, B., Yıldırım, Y. S., et al. (2009). Advanced oxidation protein products as an oxidative stress marker in allergic rhinitis. The Turkish Journal of Ear Nose and Throat, 19(6), 279-284.
AMA Aksoy F, Demirhan H, Veyseller B, Yıldırım YS, Özturan O, Basınoğlu F. Advanced oxidation protein products as an oxidative stress marker in allergic rhinitis. Tr-ENT. December 2009;19(6):279-284.
Chicago Aksoy, Fadlullah, Hasan Demirhan, Bayram Veyseller, Yavuz Selim Yıldırım, Orhan Özturan, and Filiz Basınoğlu. “Advanced Oxidation Protein Products As an Oxidative Stress Marker in Allergic Rhinitis”. The Turkish Journal of Ear Nose and Throat 19, no. 6 (December 2009): 279-84.
EndNote Aksoy F, Demirhan H, Veyseller B, Yıldırım YS, Özturan O, Basınoğlu F (December 1, 2009) Advanced oxidation protein products as an oxidative stress marker in allergic rhinitis. The Turkish Journal of Ear Nose and Throat 19 6 279–284.
IEEE F. Aksoy, H. Demirhan, B. Veyseller, Y. S. Yıldırım, O. Özturan, and F. Basınoğlu, “Advanced oxidation protein products as an oxidative stress marker in allergic rhinitis”, Tr-ENT, vol. 19, no. 6, pp. 279–284, 2009.
ISNAD Aksoy, Fadlullah et al. “Advanced Oxidation Protein Products As an Oxidative Stress Marker in Allergic Rhinitis”. The Turkish Journal of Ear Nose and Throat 19/6 (December 2009), 279-284.
JAMA Aksoy F, Demirhan H, Veyseller B, Yıldırım YS, Özturan O, Basınoğlu F. Advanced oxidation protein products as an oxidative stress marker in allergic rhinitis. Tr-ENT. 2009;19:279–284.
MLA Aksoy, Fadlullah et al. “Advanced Oxidation Protein Products As an Oxidative Stress Marker in Allergic Rhinitis”. The Turkish Journal of Ear Nose and Throat, vol. 19, no. 6, 2009, pp. 279-84.
Vancouver Aksoy F, Demirhan H, Veyseller B, Yıldırım YS, Özturan O, Basınoğlu F. Advanced oxidation protein products as an oxidative stress marker in allergic rhinitis. Tr-ENT. 2009;19(6):279-84.