A rare case of nasal Mantle cell lymphoma

Year 2010, Volume: 20 Issue: 1, 44 - 47, 10.01.2010

Gunamini Dahanayake Ashok Rokade Swapna Ghosh Vivek Raut

Abstract

A 56-year-old Caucasian man was referred to our clinic with the complaint of right sided unilateral nasal blockage which had been present for one year. Anterior rhinoscopy and computed tomograpy scan revealed a mass, filling the right nostril completely and lying in the right inferior meatus inseparable from the inferior turbinate. Following the biopsy, histopathological examination and immunohistochemical analyses, the diagnosis of Mantle cell lymphoma was established. To our knowledge, there have been no previous reports of a Mantle cell lymphoma presenting as an intranasal mass in the literature. In this article the clinical, radiological and pathological features as well as recent advances in treatment are discussed in the light of current literature.

Keywords

Immunochemotherapy, intranasal, Mantle cell lymphoma

Nadir bir intranazal Mantle hücreli lenfoma olgusu

Abstract

Elli altı yaşında beyaz ırktan bir erkek hasta, bir yıldır var olan sağ tek taraflı burun tıkanıklığı yakın- ması ile kliniğimize sevk edildi. Anteriyor rinoskopik muayenede ve bilgisayarlı tomografi incelemesin- de, sağ burun deliğini tamamen kapatan ve alt konkadan ayırt edilemeyecek şekilde alt meatusa yerleşmiş olan kitle saptandı. Biyopsi, histopato- lojik inceleme ve immünohistokimyasal analizler sonucunda hastaya Mantle hücreli lenfoma tanısı konuldu. Bilgimiz dahilinde literatürde burun içi kitlesi olarak bir Mantle hücreli lenfoma olgusu sunulmamıştır. Bu çalışmada klinik, radyolojik ve patolojik özelliklerin yanı sıra tedavideki son ilerle- meler de güncel literatür eşliğinde tartışıldı

Keywords

İmmunokemoterapi, burun içi, Mantle hücreli lenfoma.

References

• Banks PM, Chan J, Cleary ML, Delsol G, De Wolf- Peeters C, Gatter K, et al. Mantle cell lymphoma. A proposal for unification of morphologic, immuno- logic, and molecular data. Am J Surg Pathol 1992; 16:637-40.
• Fisher RI, Dahlberg S, Nathwani BN, Banks PM, Miller TP, Grogan TM. A clinical analysis of two indolent lymphoma entities: mantle cell lymphoma and marginal zone lymphoma (including the mucosa- associated lymphoid tissue and monocytoid B-cell subcategories): a Southwest Oncology Group study. Blood 1995;85:1075-82.
• Fellbaum C, Hansmann ML, Lennert K. Malignant lymphomas of the nasal cavity and paranasal sinuses. Virchows Arch A Pathol Anat Histopathol 1989; 414:399-405.
• Cleary KR, Batsakis JG. Sinonasal lymphomas. Ann Otol Rhinol Laryngol 1994;103:911-4.
• Yu KH. Primary nasal lymphoma. J HK Coll Radiol 2001;4:128-32.
• Babb MJ, Cruz RM, Puligandla B. Sinonasal muco- sa-associated lymphoid tissue lymphoma. Arch Otolaryngol Head Neck Surg 1999;125:585-8.
• Li YX, Coucke PA, Li JY, Gu DZ, Liu XF, Zhou LQ, et al. Primary non-Hodgkin’s lymphoma of the nasal cavity: prognostic significance of paranasal extension and the role of radiotherapy and chemotherapy. Cancer 1998; 83:449-56.
• Jackson RT, Fitz-Hugh GS, Constable WC. Malignant neoplasms of the nasal cavities and paranasal sinuses: (a retrospective study). Laryngoscope 1977;87:726-36.
• Zimmer LA, Carrau RL. Neoplasms of the nose and paranasal sinuses. In: Bailey BJ, Johnson JT, Newland SD, editors. Head & Neck Surgery-Otolaryngology. 4th ed. Lippincott, Williams & Wilkins; 2006. p. 1482-6
• Hartig G, Montone K, Wasik M, Chalian A, Hayden R. Nasal T-cell lymphoma and the lethal midline granuloma syndrome. Otolaryngol Head Neck Surg 1996;114:653-6.
• Gill S, Ritchie D. Therapeutic options in mantle cell lymphoma. Leuk Lymphoma 2008;49:398-409.
• Liu Z, Dong HY, Gorczyca W, Tsang P, Cohen P, Stephenson CF, et al. CD5- mantle cell lymphoma. Am J Clin Pathol 2002;118:216-24.
• Cohen PL, Kurtin PJ, Donovan KA, Hanson CA. Bone marrow and peripheral blood involvement in mantle cell lymphoma. Br J Haematol 1998;101:302-10.
• Marts BS, Longo WE, Maluf H, Vernava AM 3rd. Intermediate lymphocytic lymphoma of the small intestine. Mantle cell lymphoma. J Clin Gastroenterol 1994;18:161-2.
• Economou MA, Kopp ED, All-Ericsson C, Seregard S. Mantle cell lymphoma of the iris. Acta Ophthalmol Scand 2007;85:341-3.
• Rockacy J, Viozzi CF, Zent CS. Mantle cell lymphoma presenting as a slowly enlarging lesion of the floor of mouth in a healthy 72-year-old female: report of a case. J Oral Maxillofac Surg 2007;65:333-7.
• Geisler CH, Kolstad A, Laurell A, Andersen NS, Pedersen LB, Jerkeman M, et al. Long-term progres- sion-free survival of mantle cell lymphoma after intensive front-line immunochemotherapy with in vivo-purged stem cell rescue: a nonrandomized phase 2 multicenter study by the Nordic Lymphoma Group. Blood 2008;112:2687-93.
• Ghielmini M, Zucca E. How I treat mantle cell lym- phoma. Blood 2009;114:1469-76.