Preventing cisplatin induced ototoxicity by N-acetylcysteine and salicylate

Year 2010, Volume: 20 Issue: 4, 173 - 183, 20.08.2010

Müzeyyen Yıldırım Hasan Mete İnançlı Baver Samancı Mehmet Faruk Oktay Murat Enöz İsmail Topçu

Abstract

Objectives: In this study we investigated if CP induced ototoxicity could be prevented or reduced by the use of salicylate and N-acetylcysteine. Patients and Methods: Fifty-four patients 28 females, 26 males; mean age 37±9.5 years; range 29 to 71 years who had cisplatin chemotherapy due to solid organ tumors were enrolled in the study. The patients were randomized into three groups, with 18 patients in each group. The first group control group received cisplatin, second group received N-acetylcysteine NAC; 600 mg/day with cisplatin and the third group received salicylate 300 mg/day with cisplatin. All patients evaluated audiologically including high frequency audiometry and auditory brainstem response. Results: The cisplatin-induced ototoxic damage could be reduced in 10,000 and 12,000 Hz frequencies when N-acetylcysteine was added to the cisplatin therapy protocol. There was no decrease in the hearing loss levels of the patients who were receiving cisplatin with salicylate. Conclusion: According to auditory brainstem response testing results, there was no difference detected between N-acetylcysteine or salicylate for the amelioration of cisplatin induced ototoxicity.

Keywords

Cisplatin, N-acetylcysteine, ototoxicity, salicylate.

Cisplatine bağlı gelişen ototoksisitenin N-asetilsistein ve salisilat ile önlenmesi

Abstract

Amaç: Bu çalışmada salisilat ve N-asetilsistein kullanımıyla cisplatin kaynaklı ototoksisitenin azaltılabilirliği ya da engellenebilirliği araştırıldı.Hastalar ve Yöntemler: Solid organ tümörü nedeniyle cisplatin kemoterapi kullanan 54 hasta 28 kadın, 26 erkek; ort. yaş 37±9.5; dağılım 29-71 yıl çalışmaya dahil edildi. Hastalar her bir grupta 18 kişi olacak şekilde rastgele üç gruba ayrıldı. İlk grup kontrol grubu sadece cisplatin aldı, ikinci grup N-acetylcysteine NAC; 600 mg/gün ile birlikte cisplatin aldı ve üçüncü grup salisilat 300 mg/gün ile birlikte cisplatin aldı. Bütün hastalar yüksek frekans odyometri ve işitsel beyin sapı yanıtını içeren odyolojik incelemeyle değerlendirildi.Bulgular: Cisplatin tedavi protokolüne N-asetilsisteine eklenmesiyle, 10.000 ve 12.000 Hz frekanslarındaki cisplatin kaynaklı ototoksik hasarın azaldığı görüldü. Cisplatine ile salisilat alan hastaların işitme kayıbı seviyelerinde herhangi bir azalma görülmedi.Sonuç: Çalışmamızda işitsel beyin sapı yanıtı testi sonuçlarına bakıldığında ne N-asetilsistein ne de salisilat alan hastalar arasında cisplatin ototoksisitesini azaltma yönünden anlamlı fark bulundu

Keywords

Cisplatin, N-asetilsistein, ototoksisite, salisilat.

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