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Presence of herpesviruses in adenoid tissues of children with adenoid hypertrophy and chronic adenoiditis

Year 2012, Volume: 22 Issue: 1, 32 - 37, 12.01.2012

Abstract

Objectives: The aim of study was to determine the presence of some of the herpesviruses including herpes simplex virus HSV , Epstein-Barr virus EBV , and cytomegalovirus CMV in adenoid tissues of children with adenoid hypertrophy AH and chronic adenoiditis CA and to investigate the potential role of the herpesviruses in patogenesis of AH and CA. Patients and Methods: A total of 72 patients 41 boys, 31 girls; mean age 4 years and 2 months; range 2 to 9 years who underwent adenoidectomy or adenotonsillectomy with or without placement of a ventilation tube in our clinic between October 2007 and May 2008, were included. The patients were divided into two groups, as AH group n=42 and the CA group n=30 . Adenoid tissues collected from patients in both groups were analyzed by polymerase chain reaction PCR for the presence of HSV, EBV and CMV-DNA. Results: The results of the PCR indicated that 33.3% in the AH group and 36.6% in the CA group were herpesvirus DNA positive. Among the herpesviruses studied, HSV-DNA was detected at the highest level 14.2% and 16.6%, respectively in both groups, although the difference between the groups was not significant. EBV-DNA positiveness was 11.9% and CMV-DNA was 4.7% in the AH group, whereas, EBV-DNA positiveness was 13.3% and CMV-DNA was 6.6% in the CA group. Conclusion: Herpesviruses were determined at a high rate in adenoid tissue of children with AH and CA, suggesting that there may be a potential relationship between the presence of herpesviruses and occurrence of AH and CA in children. However, more extensive studies are required to elucidate the role of herpesviruses in the pathogenesis of AH or CA.

Adenoid hipertrofisi ve kronik adenoiditli çocuklarda adenoid dokuda herpesvirüs varlığı

Year 2012, Volume: 22 Issue: 1, 32 - 37, 12.01.2012

Abstract

Amaç: Bu çalışmanın amacı, adenoid hipertrofisi AH ve kronik adenoiditli KA çocuklarda adenoid dokuda herpessimpleks virüs HSV , Epstein-Barr virüsü EBV ve sitomegalovirüs CMV dahil olmak üzere, bazı virüslerin varlığını belirlemek ve AH ve KA patogenezinde herpesvirüslerin potansiyel rolünü araştırmaktır.Hastalar ve Yöntemler: Ekim 2007-Mayıs 2008 tarihleri arasında, kliniğimizde ventilasyon tüpü ile veya olmaksızın adenoidektomi veya adenotonsillektomi yapılan toplam 72 hasta 41 erkek, 31 kız; ort. yaş 4 yıl ve 2 ay; dağılım 2-9 yıl çalışmaya dahil edildi. Hastalar AH grubu n=42 ve KA grubu n=30 olmak üzere, iki gruba ayrıldı. Her iki gruptan alınan adenoid doku örnekleri, HSV, EBV ve CMV-DNA varlığını saptamak açısından, polimeraz zincir reaksiyon PCR yöntemi ile analiz edildi.Bulgular: Polimeraz zincir reaksiyon sonuçları, AH grubunda %33.3 ve KA grubunda %36.6 herpesvirüs DNA pozitifliği olduğunu gösterdi. Çalışılan herpesvirüsler arasında her iki grupta da en yüksek düzeyde bulunan tür, HSV-DNA idi sırasıyla %14.2 ve %16.6 , buna karşın, gruplar arasındaki fark, anlamlı değildi. AH grubunda EBV-DNA pozitifliği %11.9 ve CMV-DNA pozitifliği %4.7 iken, CA grubunda EBV-DNA pozitifliği %13.3 ve CMV-DNA pozitifliği %6.6 idi.Sonuç: Adenoid hipertrofisi ve KA olan çocukların adenoid dokusunda yüksek düzeyde herpesvirüs varlığı tespit edildi, bu da, çocuklarda herpesvirüs varlığı ve AH ve KA gelişimi arasında muhtemel bir ilişki olabileceğini düşündürmektedir. Ancak, herpesvirüslerin AH ve KA patogenezinde oynadığı rolü açıklığa kavuşturmak için, daha kapsamlı çalışmalara gereksinim vardır

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Details

Primary Language English
Journal Section Research Article
Authors

Turgut Karlıdağ This is me

Yasemin Bulut This is me

Erol Keleş This is me

Hayrettin Cengiz Alpay This is me

Adnan Seyrek This is me

İsrafil Orhan This is me

Gülden Eser Karlıdağ This is me

İrfan Kaygusuz This is me

Publication Date January 12, 2012
Published in Issue Year 2012 Volume: 22 Issue: 1

Cite

APA Karlıdağ, T., Bulut, Y., Keleş, E., Alpay, H. C., et al. (2012). Presence of herpesviruses in adenoid tissues of children with adenoid hypertrophy and chronic adenoiditis. The Turkish Journal of Ear Nose and Throat, 22(1), 32-37.
AMA Karlıdağ T, Bulut Y, Keleş E, Alpay HC, Seyrek A, Orhan İ, Eser Karlıdağ G, Kaygusuz İ. Presence of herpesviruses in adenoid tissues of children with adenoid hypertrophy and chronic adenoiditis. Tr-ENT. January 2012;22(1):32-37.
Chicago Karlıdağ, Turgut, Yasemin Bulut, Erol Keleş, Hayrettin Cengiz Alpay, Adnan Seyrek, İsrafil Orhan, Gülden Eser Karlıdağ, and İrfan Kaygusuz. “Presence of Herpesviruses in Adenoid Tissues of Children With Adenoid Hypertrophy and Chronic Adenoiditis”. The Turkish Journal of Ear Nose and Throat 22, no. 1 (January 2012): 32-37.
EndNote Karlıdağ T, Bulut Y, Keleş E, Alpay HC, Seyrek A, Orhan İ, Eser Karlıdağ G, Kaygusuz İ (January 1, 2012) Presence of herpesviruses in adenoid tissues of children with adenoid hypertrophy and chronic adenoiditis. The Turkish Journal of Ear Nose and Throat 22 1 32–37.
IEEE T. Karlıdağ, Y. Bulut, E. Keleş, H. C. Alpay, A. Seyrek, İ. Orhan, G. Eser Karlıdağ, and İ. Kaygusuz, “Presence of herpesviruses in adenoid tissues of children with adenoid hypertrophy and chronic adenoiditis”, Tr-ENT, vol. 22, no. 1, pp. 32–37, 2012.
ISNAD Karlıdağ, Turgut et al. “Presence of Herpesviruses in Adenoid Tissues of Children With Adenoid Hypertrophy and Chronic Adenoiditis”. The Turkish Journal of Ear Nose and Throat 22/1 (January 2012), 32-37.
JAMA Karlıdağ T, Bulut Y, Keleş E, Alpay HC, Seyrek A, Orhan İ, Eser Karlıdağ G, Kaygusuz İ. Presence of herpesviruses in adenoid tissues of children with adenoid hypertrophy and chronic adenoiditis. Tr-ENT. 2012;22:32–37.
MLA Karlıdağ, Turgut et al. “Presence of Herpesviruses in Adenoid Tissues of Children With Adenoid Hypertrophy and Chronic Adenoiditis”. The Turkish Journal of Ear Nose and Throat, vol. 22, no. 1, 2012, pp. 32-37.
Vancouver Karlıdağ T, Bulut Y, Keleş E, Alpay HC, Seyrek A, Orhan İ, Eser Karlıdağ G, Kaygusuz İ. Presence of herpesviruses in adenoid tissues of children with adenoid hypertrophy and chronic adenoiditis. Tr-ENT. 2012;22(1):32-7.