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Can carotid-sparing radiotherapy approaches replace with conventional techniques for the patients with T1 glottic laryngeal cancer?

Year 2012, Volume: 22 Issue: 5, 267 - 274, 01.11.2012

Abstract

Objectives: This study aims to compare the carotid artery doses applied with various radiotherapy techniques for the treatment of T1N0 glottic laryngeal cancer. Patients and Methods: Five patients were simulated with using computed tomography CT . Clinical CTV and planning target volumes PTV were created for T1N0 glottic laryngeal cancer. Planning risk volumes PRV were constructed for carotid arteries and spinal cord. Three irradiation planning, two dimension radiation therapy 2DRT , three dimension conformal radiation therapy 3DCRT , intensity modulated radiation therapy IMRT were done for each patient. Over 95% of planned target volumes were loaded with predetermined dose a total of 62.25 Gy of 2.25 Gy daily dose . Results: The comparison of the treatment planning of five T1 glottic laryngeal cancer, three involving the right vocal cord and two involving the left vocal cord, the technique of IMRT planning was provided the best carotid-sparing doses. Mean carotid V35, V50, and V63 values including 2DRT, 3DCRT, and IMRT were 70%, 47%, 35%; 55%, 15%, 5% and 28%, 6%, 0%, respectively. The statistical comparison of V35, V50 and V63 revealed significant values for 2DRT and IMRT. Dose of spinal cord did not exceed 45 Gy for any of radiation treatment planning. Between the three techniques, there was no significant difference in terms of conformity index and dose distribution was homogenous with all techniques. Conclusion: It is obvious that IMRT planning technique can decrease the carotid artery radiation doses in early stage glottic laryngeal cancer.

T1 glottik larenks kanserli hastalarda karotis koruyucu radyoterapi yaklaşımları konvansiyonel tekniklerin yerini alabilir mi?

Year 2012, Volume: 22 Issue: 5, 267 - 274, 01.11.2012

Abstract

Amaç: T1N0 glottik larenks kanseri tedavisinde çeşitli radyoterapi teknikleri arasında karotis arterlerinin maruz kaldıkları dozlar karşılaştırıldı.Hastalar ve Yöntemler: Bilgisayarlı tomografi BT kullanılarak beş hasta simüle edildi. T1N0 glottik larenks kanseri için klinik KHV ve planlanan hedef volümler PHV oluşturuldu. Karotis arterleri ve spinal kord için planlanan risk volümleri PRV çizildi. Her hasta için iki boyutlu radyoterapi 2DRT , üç boyutlu konformal radyoterapi 3DCRT ve basit yoğunluk ayarlı radyoterapi IMRT şeklinde üç planlama yapıldı. Planlanan hedef volümlerin %95’den fazlası tanımlanan dozu 2.25 Gy günlük fraksiyon dozundan 62.25 Gy toplam doz aldı.Bulgular: Üçü sağ ikisi sol vokal kord yerleşimli beş T1 glottik kanserli olgunun tedavi planları karşılaştırıldığında, karotislerin koruması en iyi basit karotis koruyucu IMRT tekniği ile sağlandı. 2DRT, 3DCRT ve IMRT tekniklerine ait karotis ortalama V35, V50 ve V63 değerleri sırasıyla; %70, %47, %35; %55, %15, %5 ve %28, %6, %0 bulundu. V35, V50 ve V63 arasında yapılan istatistiksel karşılaştırmada, 2DRT ve IMRT için anlamlı değerler saptandı. Spinal kord dozu hiçbir planda 45 Gy’i aşmadı. Her üç planlama tekniğinde uygunluk indeksi arasında anlamlı fark saptanmadı ve homojen doz dağılımı elde edildi.Sonuç: Erken evre glottik larenks kanserli hastalarda karotis arterlerinin maruz kaldığı radyasyon dozunu IMRT’nin azaltabildiğine şüphe yoktur

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Details

Primary Language English
Journal Section Research Article
Authors

Fatma Sert This is me

Ömür Karakoyun Çelik This is me

Mustafa Adnan Esassolak This is me

Publication Date November 1, 2012
Published in Issue Year 2012 Volume: 22 Issue: 5

Cite

APA Sert, F., Karakoyun Çelik, Ö., & Esassolak, M. A. (2012). Can carotid-sparing radiotherapy approaches replace with conventional techniques for the patients with T1 glottic laryngeal cancer?. The Turkish Journal of Ear Nose and Throat, 22(5), 267-274.
AMA Sert F, Karakoyun Çelik Ö, Esassolak MA. Can carotid-sparing radiotherapy approaches replace with conventional techniques for the patients with T1 glottic laryngeal cancer?. Tr-ENT. November 2012;22(5):267-274.
Chicago Sert, Fatma, Ömür Karakoyun Çelik, and Mustafa Adnan Esassolak. “Can Carotid-Sparing Radiotherapy Approaches Replace With Conventional Techniques for the Patients With T1 Glottic Laryngeal Cancer?”. The Turkish Journal of Ear Nose and Throat 22, no. 5 (November 2012): 267-74.
EndNote Sert F, Karakoyun Çelik Ö, Esassolak MA (November 1, 2012) Can carotid-sparing radiotherapy approaches replace with conventional techniques for the patients with T1 glottic laryngeal cancer?. The Turkish Journal of Ear Nose and Throat 22 5 267–274.
IEEE F. Sert, Ö. Karakoyun Çelik, and M. A. Esassolak, “Can carotid-sparing radiotherapy approaches replace with conventional techniques for the patients with T1 glottic laryngeal cancer?”, Tr-ENT, vol. 22, no. 5, pp. 267–274, 2012.
ISNAD Sert, Fatma et al. “Can Carotid-Sparing Radiotherapy Approaches Replace With Conventional Techniques for the Patients With T1 Glottic Laryngeal Cancer?”. The Turkish Journal of Ear Nose and Throat 22/5 (November 2012), 267-274.
JAMA Sert F, Karakoyun Çelik Ö, Esassolak MA. Can carotid-sparing radiotherapy approaches replace with conventional techniques for the patients with T1 glottic laryngeal cancer?. Tr-ENT. 2012;22:267–274.
MLA Sert, Fatma et al. “Can Carotid-Sparing Radiotherapy Approaches Replace With Conventional Techniques for the Patients With T1 Glottic Laryngeal Cancer?”. The Turkish Journal of Ear Nose and Throat, vol. 22, no. 5, 2012, pp. 267-74.
Vancouver Sert F, Karakoyun Çelik Ö, Esassolak MA. Can carotid-sparing radiotherapy approaches replace with conventional techniques for the patients with T1 glottic laryngeal cancer?. Tr-ENT. 2012;22(5):267-74.