An efficacy comparison of betahistin, trimetazidine and ginkgo biloba extract in patients with tinnitus
Abstract
Objectives: This study aims to investigate the efficacy of trimetazidine, betahistine and ginkgo biloba extract in the treatment of tinnitus. Patients and Methods: Complete clinical data of 90 patients 48 males, 42 females; mean age 52.3±15.1 years; range 20 to 61 years who received betahistine, trimetazidine and ginkgo biloba extract for three months were retrospectively analyzed. The patients were divided into three groups including 30 in each group according to treatments received. Pre-treatment and post-treatment scores of tinnitus disability questionnaire were compared statistically. Results: There was no statistically significant difference between pre-treatment scores of tinnitus disability questionnaire among all three groups p>0.05 , while there was a statistically significant difference among the groups following treatment p=0.019, p<0.05 . After a-three-month treatment, a decrease of 19.7±15.5 units in trimetazidine group, 12.2±12.7 units in betahistine group, and 3.80±5.9 units in ginkgo biloba extract group were found to be statistically significant, compared to the mean pretreatment tinnitus disability questionnaire scores p=0.002, p<0.01 . Conclusion: Our study results suggest that trimetazidine, betahistin and ginkgo biloba extract reduce tinnitus symptoms. However, symptomatic relief can be mostly achieved with trimetazidine treatment.
Tinnituslu hastalarda trimetazidin, betahistin ve ginkgo biloba ekstresi etkinliğinin karşılaştırılması
Abstract
Amaç: Bu çalışmada trimetazidin, betahistin ve ginkgo biloba ekstresinin tinnitus tedavisindeki etkinlikleri araştırıldı.Hastalar ve Yöntemler: Üç ay süreyle trimetazidin, betahistin ve ginkgo biloba ekstresi kullanmış ve kayıtları eksiksiz tutulmuş 90 hastanın 48 erkek, 42 kadın; ort. yaş 52.3±15.1 yıl; dağılım 20-61 yıl klinik verileri retrospektif olarak değerlendirildi. Hastalar uygulanan tedaviye göre her bir grupta 30 kişi olmak üzere üç gruba ayrıldı. Tedavi öncesi ve sonrası tinnitus engellilik anketi skorları, istatistiksel olarak karşılaştırıldı.Bulgular: Tedavi öncesi her üç grubun tinnitus engellilik anketi skorları arasında istatistiksel olarak anlamlı bir farklılık saptanmazken p>0.05 , tedavi sonrası gruplar arasında istatistiksel olarak anlamlı bir farka rastlandı p=0.019; p
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | August 19, 2013 |
| Published in Issue | Year 2013 Volume: 23 Issue: 3 |