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Squamous cell carcinoma originating from the nasal septal perforation: a rare nasal tumor

Year 2014, Volume: 24 Issue: 3, 177 - 180, 19.06.2014

Abstract

Primary squamous cell carcinoma of the nasal septum is an extremely rare malignancy. In this article, we report a case of 52-year-old female with a complaint of nasal obstruction along with occasional nasal bleeding for one year. Endoscopy showed a 2.5x2 cm perforation originating from the anterior nasal septum. Incisional biopsy result was reported as squamous cell carcinoma. The tumor was removed by functional endoscopic surgery. Histopathological examination revealed squamous cell carcinoma with safe surgery borders. No recurrence and complications were noticed after one year of follow-up. The functional impact of the treatment with high mortality rates highlights the importance of early diagnosis. We recommend the differential diagnosis of septal perforation and early wide surgical excision for such cases.

References

  • LeLiever WC, Bailey BJ, Griffiths C. Carcinoma of the nasal septum. Arch Otolaryngol 1984;110:748-51.
  • Leeman DJ, Shuler KJ, Han K, Mirani N. Dedifferentiation of primary squamous cell carcinoma arising from the nasal septum. Otolaryngol Head Neck Surg 1996 ;114:131-6.
  • Beatty CW, Pearson BW, Kern EB. Carcinoma of the nasal septum: experience with 85 cases. Otolaryngol Head Neck Surg 1982;90:90-4.
  • Schaefer SD, Hill GC. Epidermoid carcinoma of the nasal vestibule: current treatment evaluation. Laryngoscope 1980;90:1631-5.
  • Fradis M, Podoshin L, Gertner R, Sabo E. Squamous cell carcinoma of the nasal septum mucosa. Ear Nose Throat J 1993;72:217-21.
  • Kızıklkaya Z, Emir H, Ceylan K, Samim E. Nazal septumun primer yassı hücreli karsinomu. Türkiye Klinikleri J Med Sci 2008;28:977-9.
  • Torjussen W. Occupational nasal cancer caused by nickel and nickel compounds. Rhinology 1985;23:101-5.
  • Deutsch HJ. Carcinoma of the nasal septum. Report of a case and review of the literature. Ann Otol Rhinol Laryngol 1966;75:1049-57.
  • Murray A, McGarry GW. The clinical value of septal perforation biopsy. Clin Otolaryngol Allied Sci 2000;25:107-9.
  • Diamantopoulos II, Jones NS. The investigation of nasal septal perforations and ulcers. J Laryngol Otol 2001;115:541-4.
  • McGuirt WF, Thompson JN. Surgical approaches to malignant tumors of the nasal septum. Laryngoscope 1984;94:1045-9.
  • Ozkiriş M, Akbulut S, Aydin E, Unver S. Squamous cell carcinoma originating from the nasal septum: a case report. [Article in Turkish] Kulak Burun Bogaz Ihtis Derg 2006;16:91-3.
  • Echeverria-Zumarraga M, Kaiser C, Gavilan C. Nasal septal carcinoma: initial symptom of nasal septal perforation. J Laryngol Otol 1988;102:834-5.

Nazal septal perforasyondan kaynaklanan skuamöz hücreli karsinom: Nadir bir burun tümörü

Year 2014, Volume: 24 Issue: 3, 177 - 180, 19.06.2014

Abstract

Nazal septumun primer skuamöz hücreli karsinomu oldukça nadir görülen bir malignitedir. Bu yazıda, bir yıldır burun tıkanıklığı ve bazen burun kanaması yakınması olan 52 yaşında bir kadın olgu sunuldu. Endoskopide 2.5x2 cm boyutla- rında anterior nazal septum kaynaklı perforasyon gözlendi. İnsizyonel biyopsi sonucu, skuamöz hücreli karsinom olarak bildirildi. Tümör fonksiyonel endoskopik cerrahi ile çıkarıldı. Histopatolojik incelemede skuamöz hücreli karsinom güvenli cerrahi sınırıyla birlikteydi. Bir yıllık takip sonrası nüks ve komplikasyon gözlenmedi. Tedavinin fonksiyonel etkisi ve yüksek mortalite oranları, erken tanının önemini vurgulamaktadır. Septal perforasyonun ayırıcı tanısı ile birlikte bu olgularda erken geniş cerrahi eksizyon önermekteyiz

References

  • LeLiever WC, Bailey BJ, Griffiths C. Carcinoma of the nasal septum. Arch Otolaryngol 1984;110:748-51.
  • Leeman DJ, Shuler KJ, Han K, Mirani N. Dedifferentiation of primary squamous cell carcinoma arising from the nasal septum. Otolaryngol Head Neck Surg 1996 ;114:131-6.
  • Beatty CW, Pearson BW, Kern EB. Carcinoma of the nasal septum: experience with 85 cases. Otolaryngol Head Neck Surg 1982;90:90-4.
  • Schaefer SD, Hill GC. Epidermoid carcinoma of the nasal vestibule: current treatment evaluation. Laryngoscope 1980;90:1631-5.
  • Fradis M, Podoshin L, Gertner R, Sabo E. Squamous cell carcinoma of the nasal septum mucosa. Ear Nose Throat J 1993;72:217-21.
  • Kızıklkaya Z, Emir H, Ceylan K, Samim E. Nazal septumun primer yassı hücreli karsinomu. Türkiye Klinikleri J Med Sci 2008;28:977-9.
  • Torjussen W. Occupational nasal cancer caused by nickel and nickel compounds. Rhinology 1985;23:101-5.
  • Deutsch HJ. Carcinoma of the nasal septum. Report of a case and review of the literature. Ann Otol Rhinol Laryngol 1966;75:1049-57.
  • Murray A, McGarry GW. The clinical value of septal perforation biopsy. Clin Otolaryngol Allied Sci 2000;25:107-9.
  • Diamantopoulos II, Jones NS. The investigation of nasal septal perforations and ulcers. J Laryngol Otol 2001;115:541-4.
  • McGuirt WF, Thompson JN. Surgical approaches to malignant tumors of the nasal septum. Laryngoscope 1984;94:1045-9.
  • Ozkiriş M, Akbulut S, Aydin E, Unver S. Squamous cell carcinoma originating from the nasal septum: a case report. [Article in Turkish] Kulak Burun Bogaz Ihtis Derg 2006;16:91-3.
  • Echeverria-Zumarraga M, Kaiser C, Gavilan C. Nasal septal carcinoma: initial symptom of nasal septal perforation. J Laryngol Otol 1988;102:834-5.
There are 13 citations in total.

Details

Primary Language Turkish
Journal Section Case Report
Authors

İbrahim Çukurova This is me

Murat Gümüşsoy This is me

Suat Kaptaner This is me

Ömer Uğur This is me

Metin İber This is me

İlker Burak Arslan This is me

Sinan Uluyol This is me

Publication Date June 19, 2014
Published in Issue Year 2014 Volume: 24 Issue: 3

Cite

APA Çukurova, İ., Gümüşsoy, M., Kaptaner, S., Uğur, Ö., et al. (2014). Nazal septal perforasyondan kaynaklanan skuamöz hücreli karsinom: Nadir bir burun tümörü. The Turkish Journal of Ear Nose and Throat, 24(3), 177-180.
AMA Çukurova İ, Gümüşsoy M, Kaptaner S, Uğur Ö, İber M, Arslan İB, Uluyol S. Nazal septal perforasyondan kaynaklanan skuamöz hücreli karsinom: Nadir bir burun tümörü. Tr-ENT. June 2014;24(3):177-180.
Chicago Çukurova, İbrahim, Murat Gümüşsoy, Suat Kaptaner, Ömer Uğur, Metin İber, İlker Burak Arslan, and Sinan Uluyol. “Nazal Septal Perforasyondan Kaynaklanan skuamöz hücreli Karsinom: Nadir Bir Burun tümörü”. The Turkish Journal of Ear Nose and Throat 24, no. 3 (June 2014): 177-80.
EndNote Çukurova İ, Gümüşsoy M, Kaptaner S, Uğur Ö, İber M, Arslan İB, Uluyol S (June 1, 2014) Nazal septal perforasyondan kaynaklanan skuamöz hücreli karsinom: Nadir bir burun tümörü. The Turkish Journal of Ear Nose and Throat 24 3 177–180.
IEEE İ. Çukurova, “Nazal septal perforasyondan kaynaklanan skuamöz hücreli karsinom: Nadir bir burun tümörü”, Tr-ENT, vol. 24, no. 3, pp. 177–180, 2014.
ISNAD Çukurova, İbrahim et al. “Nazal Septal Perforasyondan Kaynaklanan skuamöz hücreli Karsinom: Nadir Bir Burun tümörü”. The Turkish Journal of Ear Nose and Throat 24/3 (June 2014), 177-180.
JAMA Çukurova İ, Gümüşsoy M, Kaptaner S, Uğur Ö, İber M, Arslan İB, Uluyol S. Nazal septal perforasyondan kaynaklanan skuamöz hücreli karsinom: Nadir bir burun tümörü. Tr-ENT. 2014;24:177–180.
MLA Çukurova, İbrahim et al. “Nazal Septal Perforasyondan Kaynaklanan skuamöz hücreli Karsinom: Nadir Bir Burun tümörü”. The Turkish Journal of Ear Nose and Throat, vol. 24, no. 3, 2014, pp. 177-80.
Vancouver Çukurova İ, Gümüşsoy M, Kaptaner S, Uğur Ö, İber M, Arslan İB, Uluyol S. Nazal septal perforasyondan kaynaklanan skuamöz hücreli karsinom: Nadir bir burun tümörü. Tr-ENT. 2014;24(3):177-80.