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The effect of allergy on prognosis of surgically treated nasal polyposis

Year 2014, Volume: 24 Issue: 4, 200 - 205, 25.09.2014

Abstract

Objectives: This study aims to investigate the effects of allergy existence on prognosis of surgically treated nasal polyposis. Patients and Methods: This prospective study included 29 patients 22 males, 7 females; mean age 45.9 years; range 21 to 72 years admitted to our clinic with nasal polyposis between January 2006 and December 2008. Patients were divided into two groups. Group 1 consisted of 11 patients who had positive results in skin prick test or whose positivity of allergy was confirmed by serum-specific immunoglobulin E, as a skin prick test was contraindicated. Group 2 included 18 patients who had negative allergy test results. Endoscopic and radiological evaluations of the patients were done preoperatively. Bilateral endoscopic sinus surgery was applied to all patients. Results: Statistical analysis of pre- and postoperative endoscopic and radiological evaluation findings in group 1 showed a non-significant improvement p>0.05 . Statistical analysis of pre- and postoperative endoscopic and radiological evaluation findings in group 2 demonstrated a significant improvement p<0.001, p<0.005 respectively . Conclusion: Response to surgical treatment is more limited in nasal polyposis patients with a positive allergy test.

References

  • Lee JY, Lee SH, Lee HM, Lee SH, Jung HH, Lee SW, et al. Analysis of gene expression profiles of normal human nasal mucosa and nasal polyp tissues by SAGE. J Allergy Clin Immunol 2006;118:134-42.
  • Hosemann W, Göde U, Wagner W. Epidemiology, pathophysiology of nasal polyposis, and spectrum of endonasal sinus surgery. Am J Otolaryngol 1994;15:85-98.
  • Johansson L, Akerlund A, Holmberg K, Melén I, Bende M. Prevalence of nasal polyps in adults: the Skövde population-based study. Ann Otol Rhinol Laryngol 2003;112:625-9.
  • European Academy of Allergology and Clinical Immunology. European position paper on rhinosinusitis and nasal polyps. Rhinol Suppl 2005;18:1-87.
  • Slavin RG. Sheldon Memorial Lecture. Medical management of nasal polyps and sinusitis. J Allergy Clin Immunol 1991;88:141-6.
  • Önerci M. Nazal polipozis. Ankara: Hacettepe Üniversitesi Hastaneleri Basımevi; 2006.
  • Fokkens W, Lund V, Mullol J; European Position Paper on Rhinosinusitis and Nasal Polyps Group. EP3OS 2007: European position paper on rhinosinusitis and nasal polyps 2007. A summary for otorhinolaryngologists. Rhinology 2007;45:97-101.
  • Kennedy DW, Bolger WE, Zinerich SJ. Diseases of the sinuses; diagnosis and endoscopic management. Hamilton and London: Decker; 2001.
  • Newton JR, Ah-See KW. A review of nasal polyposis. Ther Clin Risk Manag 2008;4:507-12.
  • Pata YS, Bicik E, Aygenç E, Koç C, Özdem C. Endoskopik sinüs cerrahisinin geç dönem sonuçları. Türkiye Klinikleri KBB Dergisi 2003;3:9-15.
  • Acar A, Anadolu Y, Saatci M, Akturk T, Akıner M, Ceyhan K. Alerjik ve non-alerjik sinonazal polipli hastalarda alerjik parametreler ve fonksiyonel endoskopik sinus cerrahisi sonucları. Kulak Burun Boğaz ve Bas Boyun Cerrahisi Dergisi 1996;4:49-54.
  • Pawliczak R, Kowalski ML, Danilewicz M, Wagrowska- Danilewicz M, Lewandowski A. Distribution of mast cells and eosinophils in nasal polyps from atopic and nonatopic subjects: a morphometric study. Am J Rhinol 1997;11:257-62.
  • Bunnag C, Pacharee P, Vipulakom P, Siriyananda C. A study of allergic factor in nasal polyp patients. Ann Allergy 1983;50:126-32.
  • Frenkiel S, Small P, Rochon L, Cohen C, Darragh D, Black M. Nasal polyposis--a multidisciplinary study. J Otolaryngol 1982;11:275-8.
  • Davidsson A, Hellquist HB. The so-called ‘allergic’ nasal polyp. ORL J Otorhinolaryngol Relat Spec 1993;55:30-5.
  • Slavin RG. Nasal polyps and sinusitis. In: Kaplan AP editor. Allergic Disease. Philadelphia: W.B. Saunders Company; 1997. p. 448-59.
  • English GM. Nasal polyposis, In: English GM, editor. Otolaryngology, Disease of the Nose and Sinuses. Philadelphia: JB Lippincott Co.; 1991.
  • Holmberg K, Karlsson G. Nasal polyps: medical or surgical management? Clin Exp Allergy 1996;26 Suppl 3:23-30.
  • Bonfils P. Medical treatment of paranasal sinus polyposis: a prospective study in 181 patients. Ann Otolaryngol Chir Cervicofac 1998;115:202-14. [Abstract]
  • Passàli D, Mezzedimi C, Passàli GC, Bellussi L. Efficacy of inhalation form of furosemide to prevent postsurgical relapses of rhinosinusal polyposis. ORL J Otorhinolaryngol Relat Spec 2000;62:307-10.
  • Rice HD. Endoscopic sinus surgery: Results at 2 year follow- up. Otol Head and Neck Surgery 1989;101:476-9.
  • Stammberger H. Functional Endoscopic Sinus Surgery. Philadelphia: BC Decher; 1991.
  • Bayız Ü, Dursun E, Göçer C, Korkmaz H, Ceylan K, Karaman T, et al. Nazal poliplerde allerjinin rekürrense etkisi. Türkiye Klinikleri KBB Dergisi; 2001;1:33-41.
  • Önerci M. Nazal polipozis. Ankara: Hacettepe Üniversitesi Hastaneleri Basımevi; 2006.
  • Jankowski R, Pigret D, Decroocq F. Comparison of functional results after ethmoidectomy and nasalization for diffuse and severe nasal polyposis. Acta Otolaryngol 1997;117:601-8.

Alerjinin cerrahi olarak tedavi edilen nazal polipozis prognozuna etkisi

Year 2014, Volume: 24 Issue: 4, 200 - 205, 25.09.2014

Abstract

Amaç: Bu çalışmada alerji varlığının cerrahi olarak tedavi edilen nazal polipozis prognozu üzerine etkisi araştırıldı.Hastalar ve Yöntemler: Bu prospektif çalışmaya Ocak 2006 - Aralık 2008 tarihleri arasında kliniğimize başvuran nazal polipozisli 29 hasta 22 erkek, 7 kadın; ort. yaş 45.9, dağılım 21-72 yıl alındı. Hastalar iki gruba ayrıldı. Grup 1’e deri prick testi pozitif olan veya deri prick test kontrendikasyonu olduğu için serum spesifik immünoglobulin E bakılarak alerji pozitifliği tespit edilen 11 hasta alındı. Grup 2’ye ise, alerji testleri negatif olan 18 hasta alındı. Hastaların ameliyat öncesi endoskopik ve radyolojik değerlendirilmeleri yapıldı. Tüm hastalara iki taraflı endoskopik sinüs cerrahisi uygulandı.Bulgular: Grup 1’in ameliyat öncesi ve sonrası endoskopik ve radyolojik değerlendirme sonuçlarının istatistiksel analizi, iyileşmenin anlamlı düzeyde olmadığını gösterdi p>0.05 . Grup 2’nin ameliyat öncesi ve sonrası endoskopik ve radyolojik değerlendirme sonuçlarının istatistiksel analizi ise, anlamlı bir düzelme olduğunu gösterdi sırasıyla, p

References

  • Lee JY, Lee SH, Lee HM, Lee SH, Jung HH, Lee SW, et al. Analysis of gene expression profiles of normal human nasal mucosa and nasal polyp tissues by SAGE. J Allergy Clin Immunol 2006;118:134-42.
  • Hosemann W, Göde U, Wagner W. Epidemiology, pathophysiology of nasal polyposis, and spectrum of endonasal sinus surgery. Am J Otolaryngol 1994;15:85-98.
  • Johansson L, Akerlund A, Holmberg K, Melén I, Bende M. Prevalence of nasal polyps in adults: the Skövde population-based study. Ann Otol Rhinol Laryngol 2003;112:625-9.
  • European Academy of Allergology and Clinical Immunology. European position paper on rhinosinusitis and nasal polyps. Rhinol Suppl 2005;18:1-87.
  • Slavin RG. Sheldon Memorial Lecture. Medical management of nasal polyps and sinusitis. J Allergy Clin Immunol 1991;88:141-6.
  • Önerci M. Nazal polipozis. Ankara: Hacettepe Üniversitesi Hastaneleri Basımevi; 2006.
  • Fokkens W, Lund V, Mullol J; European Position Paper on Rhinosinusitis and Nasal Polyps Group. EP3OS 2007: European position paper on rhinosinusitis and nasal polyps 2007. A summary for otorhinolaryngologists. Rhinology 2007;45:97-101.
  • Kennedy DW, Bolger WE, Zinerich SJ. Diseases of the sinuses; diagnosis and endoscopic management. Hamilton and London: Decker; 2001.
  • Newton JR, Ah-See KW. A review of nasal polyposis. Ther Clin Risk Manag 2008;4:507-12.
  • Pata YS, Bicik E, Aygenç E, Koç C, Özdem C. Endoskopik sinüs cerrahisinin geç dönem sonuçları. Türkiye Klinikleri KBB Dergisi 2003;3:9-15.
  • Acar A, Anadolu Y, Saatci M, Akturk T, Akıner M, Ceyhan K. Alerjik ve non-alerjik sinonazal polipli hastalarda alerjik parametreler ve fonksiyonel endoskopik sinus cerrahisi sonucları. Kulak Burun Boğaz ve Bas Boyun Cerrahisi Dergisi 1996;4:49-54.
  • Pawliczak R, Kowalski ML, Danilewicz M, Wagrowska- Danilewicz M, Lewandowski A. Distribution of mast cells and eosinophils in nasal polyps from atopic and nonatopic subjects: a morphometric study. Am J Rhinol 1997;11:257-62.
  • Bunnag C, Pacharee P, Vipulakom P, Siriyananda C. A study of allergic factor in nasal polyp patients. Ann Allergy 1983;50:126-32.
  • Frenkiel S, Small P, Rochon L, Cohen C, Darragh D, Black M. Nasal polyposis--a multidisciplinary study. J Otolaryngol 1982;11:275-8.
  • Davidsson A, Hellquist HB. The so-called ‘allergic’ nasal polyp. ORL J Otorhinolaryngol Relat Spec 1993;55:30-5.
  • Slavin RG. Nasal polyps and sinusitis. In: Kaplan AP editor. Allergic Disease. Philadelphia: W.B. Saunders Company; 1997. p. 448-59.
  • English GM. Nasal polyposis, In: English GM, editor. Otolaryngology, Disease of the Nose and Sinuses. Philadelphia: JB Lippincott Co.; 1991.
  • Holmberg K, Karlsson G. Nasal polyps: medical or surgical management? Clin Exp Allergy 1996;26 Suppl 3:23-30.
  • Bonfils P. Medical treatment of paranasal sinus polyposis: a prospective study in 181 patients. Ann Otolaryngol Chir Cervicofac 1998;115:202-14. [Abstract]
  • Passàli D, Mezzedimi C, Passàli GC, Bellussi L. Efficacy of inhalation form of furosemide to prevent postsurgical relapses of rhinosinusal polyposis. ORL J Otorhinolaryngol Relat Spec 2000;62:307-10.
  • Rice HD. Endoscopic sinus surgery: Results at 2 year follow- up. Otol Head and Neck Surgery 1989;101:476-9.
  • Stammberger H. Functional Endoscopic Sinus Surgery. Philadelphia: BC Decher; 1991.
  • Bayız Ü, Dursun E, Göçer C, Korkmaz H, Ceylan K, Karaman T, et al. Nazal poliplerde allerjinin rekürrense etkisi. Türkiye Klinikleri KBB Dergisi; 2001;1:33-41.
  • Önerci M. Nazal polipozis. Ankara: Hacettepe Üniversitesi Hastaneleri Basımevi; 2006.
  • Jankowski R, Pigret D, Decroocq F. Comparison of functional results after ethmoidectomy and nasalization for diffuse and severe nasal polyposis. Acta Otolaryngol 1997;117:601-8.
There are 25 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Talih Özdaş This is me

Utku Doğan This is me

Kürşat Murat Özcan This is me

Ayşe Adin Selçuk This is me

Hüseyin Dere This is me

Publication Date September 25, 2014
Published in Issue Year 2014 Volume: 24 Issue: 4

Cite

APA Özdaş, T., Doğan, U., Özcan, K. M., Selçuk, A. A., et al. (2014). Alerjinin cerrahi olarak tedavi edilen nazal polipozis prognozuna etkisi. The Turkish Journal of Ear Nose and Throat, 24(4), 200-205.
AMA Özdaş T, Doğan U, Özcan KM, Selçuk AA, Dere H. Alerjinin cerrahi olarak tedavi edilen nazal polipozis prognozuna etkisi. Tr-ENT. September 2014;24(4):200-205.
Chicago Özdaş, Talih, Utku Doğan, Kürşat Murat Özcan, Ayşe Adin Selçuk, and Hüseyin Dere. “Alerjinin Cerrahi Olarak Tedavi Edilen Nazal Polipozis Prognozuna Etkisi”. The Turkish Journal of Ear Nose and Throat 24, no. 4 (September 2014): 200-205.
EndNote Özdaş T, Doğan U, Özcan KM, Selçuk AA, Dere H (September 1, 2014) Alerjinin cerrahi olarak tedavi edilen nazal polipozis prognozuna etkisi. The Turkish Journal of Ear Nose and Throat 24 4 200–205.
IEEE T. Özdaş, U. Doğan, K. M. Özcan, A. A. Selçuk, and H. Dere, “Alerjinin cerrahi olarak tedavi edilen nazal polipozis prognozuna etkisi”, Tr-ENT, vol. 24, no. 4, pp. 200–205, 2014.
ISNAD Özdaş, Talih et al. “Alerjinin Cerrahi Olarak Tedavi Edilen Nazal Polipozis Prognozuna Etkisi”. The Turkish Journal of Ear Nose and Throat 24/4 (September 2014), 200-205.
JAMA Özdaş T, Doğan U, Özcan KM, Selçuk AA, Dere H. Alerjinin cerrahi olarak tedavi edilen nazal polipozis prognozuna etkisi. Tr-ENT. 2014;24:200–205.
MLA Özdaş, Talih et al. “Alerjinin Cerrahi Olarak Tedavi Edilen Nazal Polipozis Prognozuna Etkisi”. The Turkish Journal of Ear Nose and Throat, vol. 24, no. 4, 2014, pp. 200-5.
Vancouver Özdaş T, Doğan U, Özcan KM, Selçuk AA, Dere H. Alerjinin cerrahi olarak tedavi edilen nazal polipozis prognozuna etkisi. Tr-ENT. 2014;24(4):200-5.