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A rare late complication of radiation therapy: bilaterally recurrent laryngeal nerve paralysis

Year 2014, Volume: 24 Issue: 6, 344 - 348, 25.12.2014

Bora Başaran Selin Ünsaler Kadir Serkan Orhan Ökkeş Erkan Kıyak

Abstract

Peripheral neuropathy is a late complication of radiation therapy, which is least and probably threatening. As it occurs many years after the remission is achieved with a usually irreversible clinical presentation, it significantly increases morbidity in cancer survivors and has an adverse effect on the quality of life. In this article, we report a 39-year-old male patient of bilateral recurrent laryngeal nerve paralysis which developed eight years after the treatment of stage T1b glottic laryngeal carcinoma with primary radiation therapy and was treated by transverse laser cordotomy.

Keywords

Cranial nerve palsy late complication radiation therapy recurrent laryngeal nerve

References

  • Popovtzer A, Eisbruch A. Radiotherapy for Head and Neck Cancer: Radiation Physics, Radiobiology, and Clinical Principles. In: Flint PW, Haughey BH, Lund VJ, Niparko JK, Richardson MA, Robbins KT, et al. Cummings Otolaryngology-Head and Neck Surgery. Chapter 77, 5th ed. Philadelphia: Mosby Elsevier; 2010. p. 1030-50.
  • Ballantyne AJ. Late sequelae of radiation therapy in cancer of the head and neck with particular reference to the nasopharynx. Am J Surg 1975;130:433-6.
  • Berger PS, Bataini JP. Radiation-induced cranial nerve palsy. Cancer 1977;40:152-5.
  • Delanian S, Lefaix JL, Pradat PF. Radiation-induced neuropathy in cancer survivors. Radiother Oncol 2012;105:273-82.
  • Delanian S, Lefaix JL. The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway. Radiother Oncol 2004;73:119-31.
  • Johansson S, Svensson H, Denekamp J. Dose response and latency for radiationinduced fibrosis, edema, and neuropathy in breast cancer patients. Int J Radiat Oncol Biol Phys 2002;52:1207-19.
  • Powell S, Cooke J, Parsons C. Radiation-induced brachial plexus injury: followup of two different fractionation schedules. Radiother Oncol 1990;18:213-20.
  • Luk YS, Shum JS, Sze HC, Chan LL, Ng WT, Lee AW. Predictive factors and radiological features of radiation-induced cranial nerve palsy in patients with nasopharyngeal carcinoma following radical radiotherapy. Oral Oncol 2013;49:49-54.
  • Flickinger JC. Cranial nerves. In: Shrieve DC, Loeffler JS, editors. Human radiation injury. Philadelphia: Lippincott Williams Wilkins; 2011. p. 210-6.
  • Rong X, Tang Y, Chen M, Lu K, Peng Y. Radiation- induced cranial neuropathy in patients with nasopharyngeal carcinoma. A follow-up study. Strahlenther Onkol 2012;188:282-6.
  • Kong L, Lu JJ, Liss AL, Hu C, Guo X, Wu Y, et al. Radiation-induced cranial nerve palsy: a cross- sectional study of nasopharyngeal cancer patients after definitive radiotherapy. Int J Radiat Oncol Biol Phys 2011;79:1421-7.
  • Takimoto T, Saito Y, Suzuki M, Nishimura T. Radiation- induced cranial nervepalsy: hypoglossal nerve and vocal cord palsies. J Laryngol Otol 1991;105:44-5.
  • Lin YS, Jen YM, Lin JC. Radiation-related cranial nerve palsy in patients with nasopharyngeal carcinoma. Cancer 2002;95:404-9.
  • Zadeh G, Buckle C, Shannon P, Massicotte E, Wong S, Guha A. Radiation induced peripheral nerve tumors: case series and review of the literature. J Neurooncol 2007;83:205-12.
  • Miller FR, Wanamaker JR, Lavertu P, Wood BG. Magnetic resonance imaging and the management of parapharyngeal space tumors. Head Neck 1996;18:67-77.

Radyoterapinin nadir bir geç komplikasyonu: İki taraflı reküren larengeal sinir paralizisi

Year 2014, Volume: 24 Issue: 6, 344 - 348, 25.12.2014

Bora Başaran Selin Ünsaler Kadir Serkan Orhan Ökkeş Erkan Kıyak

Abstract

Radyoterapiye bağlı periferik nöropati, radyoterapinin geç komplikasyonları içinde en az bilineni ve belki de en korkutucu olanıdır. Hastalık remisyonundan yıllar sonra ortaya çıkması ve çoğu zaman klinik tablonun geri dönüşsüz olması, kanser ile mücadelede başarılı olmuş hastalarda morbiditeyi önemli düzeyde artırmakta ve yaşam kalitesini olumsuz etkilemek- tedir. Bu yazıda, T1b evreli glottik larenks kanseri nedeniyle primer radyoterapi gördükten sekiz yıl sonra iki taraflı reküren larengeal sinir paralizisi gelişen ve transvers lazer kordotomi ile tedavi edilen 39 yaşında bir erkek hasta sunuldu

Keywords

Kraniyal sinir paralizisi geç komplikasyon radyasyon terapisi reküren larengeal sinir

References

  • Popovtzer A, Eisbruch A. Radiotherapy for Head and Neck Cancer: Radiation Physics, Radiobiology, and Clinical Principles. In: Flint PW, Haughey BH, Lund VJ, Niparko JK, Richardson MA, Robbins KT, et al. Cummings Otolaryngology-Head and Neck Surgery. Chapter 77, 5th ed. Philadelphia: Mosby Elsevier; 2010. p. 1030-50.
  • Ballantyne AJ. Late sequelae of radiation therapy in cancer of the head and neck with particular reference to the nasopharynx. Am J Surg 1975;130:433-6.
  • Berger PS, Bataini JP. Radiation-induced cranial nerve palsy. Cancer 1977;40:152-5.
  • Delanian S, Lefaix JL, Pradat PF. Radiation-induced neuropathy in cancer survivors. Radiother Oncol 2012;105:273-82.
  • Delanian S, Lefaix JL. The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway. Radiother Oncol 2004;73:119-31.
  • Johansson S, Svensson H, Denekamp J. Dose response and latency for radiationinduced fibrosis, edema, and neuropathy in breast cancer patients. Int J Radiat Oncol Biol Phys 2002;52:1207-19.
  • Powell S, Cooke J, Parsons C. Radiation-induced brachial plexus injury: followup of two different fractionation schedules. Radiother Oncol 1990;18:213-20.
  • Luk YS, Shum JS, Sze HC, Chan LL, Ng WT, Lee AW. Predictive factors and radiological features of radiation-induced cranial nerve palsy in patients with nasopharyngeal carcinoma following radical radiotherapy. Oral Oncol 2013;49:49-54.
  • Flickinger JC. Cranial nerves. In: Shrieve DC, Loeffler JS, editors. Human radiation injury. Philadelphia: Lippincott Williams Wilkins; 2011. p. 210-6.
  • Rong X, Tang Y, Chen M, Lu K, Peng Y. Radiation- induced cranial neuropathy in patients with nasopharyngeal carcinoma. A follow-up study. Strahlenther Onkol 2012;188:282-6.
  • Kong L, Lu JJ, Liss AL, Hu C, Guo X, Wu Y, et al. Radiation-induced cranial nerve palsy: a cross- sectional study of nasopharyngeal cancer patients after definitive radiotherapy. Int J Radiat Oncol Biol Phys 2011;79:1421-7.
  • Takimoto T, Saito Y, Suzuki M, Nishimura T. Radiation- induced cranial nervepalsy: hypoglossal nerve and vocal cord palsies. J Laryngol Otol 1991;105:44-5.
  • Lin YS, Jen YM, Lin JC. Radiation-related cranial nerve palsy in patients with nasopharyngeal carcinoma. Cancer 2002;95:404-9.
  • Zadeh G, Buckle C, Shannon P, Massicotte E, Wong S, Guha A. Radiation induced peripheral nerve tumors: case series and review of the literature. J Neurooncol 2007;83:205-12.
  • Miller FR, Wanamaker JR, Lavertu P, Wood BG. Magnetic resonance imaging and the management of parapharyngeal space tumors. Head Neck 1996;18:67-77.
There are 15 citations in total.

Details

Primary Language Turkish
Journal Section Case Report
Authors

Bora Başaran This is me

Selin Ünsaler This is me

Kadir Serkan Orhan This is me

Ökkeş Erkan Kıyak This is me

Publication Date December 25, 2014
Published in Issue Year 2014 Volume: 24 Issue: 6

Cite

APA Başaran, B., Ünsaler, S., Orhan, K. S., Kıyak, Ö. E. (2014). Radyoterapinin nadir bir geç komplikasyonu: İki taraflı reküren larengeal sinir paralizisi. The Turkish Journal of Ear Nose and Throat, 24(6), 344-348.
AMA Başaran B, Ünsaler S, Orhan KS, Kıyak ÖE. Radyoterapinin nadir bir geç komplikasyonu: İki taraflı reküren larengeal sinir paralizisi. Tr-ENT. December 2014;24(6):344-348.
Chicago Başaran, Bora, Selin Ünsaler, Kadir Serkan Orhan, and Ökkeş Erkan Kıyak. “Radyoterapinin Nadir Bir Geç Komplikasyonu: İki Taraflı reküren Larengeal Sinir Paralizisi”. The Turkish Journal of Ear Nose and Throat 24, no. 6 (December 2014): 344-48.
EndNote Başaran B, Ünsaler S, Orhan KS, Kıyak ÖE (December 1, 2014) Radyoterapinin nadir bir geç komplikasyonu: İki taraflı reküren larengeal sinir paralizisi. The Turkish Journal of Ear Nose and Throat 24 6 344–348.
IEEE B. Başaran, S. Ünsaler, K. S. Orhan, and Ö. E. Kıyak, “Radyoterapinin nadir bir geç komplikasyonu: İki taraflı reküren larengeal sinir paralizisi”, Tr-ENT, vol. 24, no. 6, pp. 344–348, 2014.
ISNAD Başaran, Bora et al. “Radyoterapinin Nadir Bir Geç Komplikasyonu: İki Taraflı reküren Larengeal Sinir Paralizisi”. The Turkish Journal of Ear Nose and Throat 24/6 (December 2014), 344-348.
JAMA Başaran B, Ünsaler S, Orhan KS, Kıyak ÖE. Radyoterapinin nadir bir geç komplikasyonu: İki taraflı reküren larengeal sinir paralizisi. Tr-ENT. 2014;24:344–348.
MLA Başaran, Bora et al. “Radyoterapinin Nadir Bir Geç Komplikasyonu: İki Taraflı reküren Larengeal Sinir Paralizisi”. The Turkish Journal of Ear Nose and Throat, vol. 24, no. 6, 2014, pp. 344-8.
Vancouver Başaran B, Ünsaler S, Orhan KS, Kıyak ÖE. Radyoterapinin nadir bir geç komplikasyonu: İki taraflı reküren larengeal sinir paralizisi. Tr-ENT. 2014;24(6):344-8.