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Assessment of patients with nasal polyposis by the neutrophil-to-lymphocyte ratio and eosinophil-to-lymphocyte ratio

Year 2015, Volume: 25 Issue: 4, 193 - 199, 25.09.2015

Abstract

Objectives: This study aims to investigate the neutrophil-to-lymphocyte ratio NLR and eosinophil-to-lymphocyte ratio ELR levels in recurrent and non-recurrent nasal polyposis, and identify how the NLR and ELR reflect the inflammatory status in this specific diagnosis preoperatively. Patients and Methods: A total of 158 patients 102 males, 56 females; mean age 29.40±5.44 years; range 14 to 48 years were included in the study. The patients were divided into two groups: group 1 included 80 recurrent nasal polyposis patients 44 males, 36 females; mean age 30.0±9.4 years; range 14 to 47 years and group 2 included 78 non-recurrent nasal polyposis patients without allergic or atopic backgrounds 58 males, 20 females; mean age 28.8±10.1 years; range 17 to 48 years . The NLR and ELR values for each patient were calculated from the complete blood counts taken before surgery. The values of preoperative white blood cell, neutrophil, lymphocyte, eosinophil, NLR and ELR were compared for each group, and also in between the two groups. Results: The preoperative neutrophil, eosinophil, NLR and ELR values of group 1 were significantly higher than group 2 p=0.042, p=0.013, p=0.019, and p=0.0001 respectively . Conclusion: Neutrophil-to-lymphocyte and ELR measurements can be used effectively in patients with nasal polyposis as an auxiliary method in deciding for the necessity of recurrence follow-ups.

References

  • Brain TJ. Historical background of nasal polyps. In: Settipane G, Lund V, Berstein J, Tos M, editors. Nasal Polyps, Epidemiology, Pathology, Treatment. Rhode Island: Oceanside Publications; 1997. p. 7-15.
  • Dingsİr G, Kramer J, Olsholt R, Sİderstrİm T. Flunisolide nasal spray 0.025% in the prophylactic treatment of nasal polyposis after polypectomy. A randomized, double blind, parallel, placebo controlled study. Rhinology 1985;23:49-58.
  • Bateman ND, Fahy C, Woolford TJ. Nasal polyps: still more questions than answers. J Laryngol Otol 2003;117:1-9.
  • Hellquist HB. Nasal polyps update. Histopathology. Allergy Asthma Proc 1996;17:237-42.
  • Berstein JM, Nasal polyps. In: Kennedy DW, Bolger WE, Zinreich SJ, editors. Diseases of the Sinuses Diagnoses and Management. Hamilton: B.C. Decker; 2001. p. 69-75.
  • Fogar P, Sperti C, Basso D, Sanzari MC, Greco E, Davoli C, et al. Decreased total lymphocyte counts in pancreatic cancer: an index of adverse outcome. Pancreas 2006;32:22-8.
  • Wichmann MW, Meyer G, Adam M, Höchtlen- Vollmar W, Angele MK, Schalhorn A, et al. Detrimental immunologic effects of preoperative chemoradiotherapy in advanced rectal cancer. Dis Colon Rectum 2003;46:875-87.
  • Kusumanto YH, Dam WA, Hospers GA, Meijer C, Mulder NH. Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating vascular endothelial growth factor. Angiogenesis 2003;6:283-7.
  • Roxburgh CS, McMillan DC. Role of systemic inflammatory response in predicting survival in patients with primary operable cancer. Future Oncol 2010;6:149-63.
  • Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol 2008;102:653-7.
  • Halazun KJ, Aldoori A, Malik HZ, Al-Mukhtar A, Prasad KR, Toogood GJ, et al. Elevated preoperative neutrophil to lymphocyte ratio predicts survival following hepatic resection for colorectal liver metastases. Eur J Surg Oncol 2008;34:55-60.
  • Bachert C, Hormann K, Mosges R, Rasp G, Riechelmann H, Muller R, et al. An update on the diagnosis and treatment of sinusitis and nasal polyposis. Allergy 2003;58:176-91.
  • Watelet JB, Claeys C, Perez-Novo C, Gevaert P, Van Cauwenberge P, Bachert C. Transforming growth factor beta1 in nasal remodeling: differences between chronic rhinosinusitis and nasal polyposis. Am J Rhinol 2004;18:267-72.
  • Zaravinos A, Bizakis J, Soufla G, Sourvinos G, Spandidos DA. Mutations and differential expression of the ras family genes in human nasal polyposis. Int J Oncol 2007;31:1051-9.
  • Little SC, Early SB, Woodard CR, Shonka DC Jr, Han JK, Borish L, et al. Dual action of TGF-beta1 on nasal-polyp derived fibroblasts. Laryngoscope 2008;118:320-4.
  • Hedman J, Kaprio J, Poussa T, Nieminen MM. Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study. Int J Epidemiol 1999;28:717-22.
  • Larsen PL, Tos M. Site of origin of nasal polyps. Transcranially removed naso-ethmoidal blocks as a screening method for nasal polyps in autopsy material. Rhinology 1995;33:185-8.
  • Settipane GA. Epidemiology of nasal polyps. Allergy Asthma Proc 1996;17:231-6.
  • Bernstein JM, Kansal R. Superantigen hypothesis for the early development of chronic hyperplastic sinusitis with massive nasal polyposis. Curr Opin Otolaryngol Head Neck Surg 2005;13:39-44.
  • Van Zele T, Gevaert P, Watelet JB, Claeys G, Holtappels G, Claeys C, et al. Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis. J Allergy Clin Immunol 2004;114:981-3.
  • Conley DB, Tripathi A, Ditto AM, Reid K, Grammer LC, Kern RC. Chronic sinusitis with nasal polyps: staphylococcal exotoxin immunoglobulin E and cellular inflammation. Am J Rhinol 2004;18:273-8.
  • Gevaert P, Holtappels G, Johansson SG, Cuvelier C, Cauwenberge P, Bachert C. Organization of secondary lymphoid tissue and local IgE formation to Staphylococcus aureus enterotoxins in nasal polyp tissue. Allergy 2005;60:71-9.
  • Arruda-Olson AM, Reeder GS, Bell MR, Weston SA, Roger VL. Neutrophilia predicts death and heart failure after myocardial infarction: a community- based study. Circ Cardiovasc Qual Outcomes 2009;2:656-62.
  • Rudiger A, Burckhardt OA, Harpes P, Müller SA, Follath F. The relative lymphocyte count on hospital admission is a risk factor for long-term mortality in patients with acute heart failure. Am J Emerg Med 2006;24:451-4.
  • Nşñez J, Nşñez E, Bodí V, Sanchis J, Miñana G, Mainar L, et al. Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction. Am J Cardiol 2008;101:747-52
  • Walsh SR, Cook EJ, Goulder F, Justin TA, Keeling NJ. Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer. J Surg Oncol 2005;91:181-4.
  • Sarraf KM, Belcher E, Raevsky E, Nicholson AG, Goldstraw P, Lim E. Neutrophil/lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancer. J Thorac Cardiovasc Surg 2009;137:425-8.
  • Turkmen K, Guney I, Yerlikaya FH, Tonbul HZ. The relationship between neutrophil-to-lymphocyte ratio and inflammation in end-stage renal disease patients. Ren Fail 2012;34:155-9.
  • Kuyumcu ME, Yesil Y, Oztürk ZA, Kizilarslanoğlu C, Etgül S, Halil M, et al. The evaluation of neutrophil- lymphocyte ratio in Alzheimer's disease. Dement Geriatr Cogn Disord 2012;34:69-74.
  • Wittekindt C, Hess A, Bloch W, Sultanie S, Michel O. Immunohistochemical expression of VEGF and VEGF receptors in nasal polyps as compared to normal turbinate mucosa. Eur Arch Otorhinolaryngol 2002;259:294-8.
  • Wittekindt C, Hess A, Bloch W, Sultanie S, Michel O. Immunohistochemical expression of VEGF and VEGF receptors in nasal polyps as compared to normal turbinate mucosa. Eur Arch Otorhinolaryngol 2002;259:294-8.
  • Vogel M, Miescher S, Biaggi C, Stadler BM. Human anti-IgE antibodies by repertoire cloning. Eur J Immunol 1994;24:1200-7.
  • Di Lorenzo G, Drago A, Esposito Pellitteri M, Candore G, Colombo A, Gervasi F, et al. Measurement of inflammatory mediators of mast cells and eosinophils in native nasal lavage fluid in nasal polyposis. Int Arch Allergy Immunol 2001;125:164-75.
  • Matsuwaki Y, Ookushi T, Asaka D, Mori E, Nakajima T, Yoshida T, et al. Chronic rhinosinusitis: risk factors for the recurrence of chronic rhinosinusitis based on 5-year follow-up after endoscopic sinus surgery. Int Arch Allergy Immunol 2008;146:77-81.
  • Stammberger H. Surgical treatment of nasal polyps: past, present, and future. Allergy 1999;54 Suppl 53:7-11.
  • Delbrouck C, Gabius HJ, Vandenhoven G, Kiss R, Hassid S. Budesonide-dependent modulation of expression of macrophage migration inhibitory factor in a polyposis model: evidence for differential regulation in surface and glandular epithelia. Ann Otol Rhinol Laryngol 2004;113:544-51.

Nazal polipozisli hastaların nötrofil/lenfosit oranı ve eozinofil/lenfosit oranı ile değerlendirilmesi

Year 2015, Volume: 25 Issue: 4, 193 - 199, 25.09.2015

Abstract

Amaç: Bu çalışmada reküren ve nonreküren nazal polipoziste nötrofil/lenfosit oranı NLO ve eozinofil/lenfosit oranı ELO düzeyleri araştırıldı ve NLO ile ELO’nun bu spesifik tanıda ameliyat öncesi enflamatuvar durumu nasıl yansıttığı belirlendi.Hastalar ve Yöntemler: Çalışmaya toplam 158 hasta 102 erkek, 56 kadın; ort. yaş 29.40±5.44 yıl; dağılım 14-48 yıl dahil edildi. Hastalar iki gruba ayrıldı: grup 1’e 80 reküren nazal polipozis hastası 44 erkek, 36 kadın; ort. yaş 30.0±9.4 yıl; dağılım 14-47 yıl ve grup 2’ye alerjik veya atopik geçmişi olmayan 78 nonreküren nazal polipozis hastası 58 erkek, 20 kadın; ort. yaş 28.8±10.1 yıl; dağılım 17-48 yıl dahil edildi. Her hasta için NLO ve ELO değerleri cerrahi öncesi alınan tam kan sayımlarından hesaplandı. Her grup için ve iki grup arasında ameliyat öncesi beyaz kan hücresi, nötrofil, lenfosit, eozinofil, NLO ve ELO değerleri karşılaştırıldı.Bulgular: Grup 1’in ameliyat öncesi nötrofil, eozinofil, NLO ve ELO değerleri grup 2’den anlamlı olarak yüksekti sırasıyla, p=0.042, p=0.013, p=0.019 ve p=0.0001 .Sonuç: Nötrofil/lenfosit ve ELO ölçümleri nazal polipozisli hastalarda reküren takiplerin gerekliliğine karar vermede yardımcı bir yöntem olarak etkili bir şekilde kullanılabilir

References

  • Brain TJ. Historical background of nasal polyps. In: Settipane G, Lund V, Berstein J, Tos M, editors. Nasal Polyps, Epidemiology, Pathology, Treatment. Rhode Island: Oceanside Publications; 1997. p. 7-15.
  • Dingsİr G, Kramer J, Olsholt R, Sİderstrİm T. Flunisolide nasal spray 0.025% in the prophylactic treatment of nasal polyposis after polypectomy. A randomized, double blind, parallel, placebo controlled study. Rhinology 1985;23:49-58.
  • Bateman ND, Fahy C, Woolford TJ. Nasal polyps: still more questions than answers. J Laryngol Otol 2003;117:1-9.
  • Hellquist HB. Nasal polyps update. Histopathology. Allergy Asthma Proc 1996;17:237-42.
  • Berstein JM, Nasal polyps. In: Kennedy DW, Bolger WE, Zinreich SJ, editors. Diseases of the Sinuses Diagnoses and Management. Hamilton: B.C. Decker; 2001. p. 69-75.
  • Fogar P, Sperti C, Basso D, Sanzari MC, Greco E, Davoli C, et al. Decreased total lymphocyte counts in pancreatic cancer: an index of adverse outcome. Pancreas 2006;32:22-8.
  • Wichmann MW, Meyer G, Adam M, Höchtlen- Vollmar W, Angele MK, Schalhorn A, et al. Detrimental immunologic effects of preoperative chemoradiotherapy in advanced rectal cancer. Dis Colon Rectum 2003;46:875-87.
  • Kusumanto YH, Dam WA, Hospers GA, Meijer C, Mulder NH. Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating vascular endothelial growth factor. Angiogenesis 2003;6:283-7.
  • Roxburgh CS, McMillan DC. Role of systemic inflammatory response in predicting survival in patients with primary operable cancer. Future Oncol 2010;6:149-63.
  • Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol 2008;102:653-7.
  • Halazun KJ, Aldoori A, Malik HZ, Al-Mukhtar A, Prasad KR, Toogood GJ, et al. Elevated preoperative neutrophil to lymphocyte ratio predicts survival following hepatic resection for colorectal liver metastases. Eur J Surg Oncol 2008;34:55-60.
  • Bachert C, Hormann K, Mosges R, Rasp G, Riechelmann H, Muller R, et al. An update on the diagnosis and treatment of sinusitis and nasal polyposis. Allergy 2003;58:176-91.
  • Watelet JB, Claeys C, Perez-Novo C, Gevaert P, Van Cauwenberge P, Bachert C. Transforming growth factor beta1 in nasal remodeling: differences between chronic rhinosinusitis and nasal polyposis. Am J Rhinol 2004;18:267-72.
  • Zaravinos A, Bizakis J, Soufla G, Sourvinos G, Spandidos DA. Mutations and differential expression of the ras family genes in human nasal polyposis. Int J Oncol 2007;31:1051-9.
  • Little SC, Early SB, Woodard CR, Shonka DC Jr, Han JK, Borish L, et al. Dual action of TGF-beta1 on nasal-polyp derived fibroblasts. Laryngoscope 2008;118:320-4.
  • Hedman J, Kaprio J, Poussa T, Nieminen MM. Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study. Int J Epidemiol 1999;28:717-22.
  • Larsen PL, Tos M. Site of origin of nasal polyps. Transcranially removed naso-ethmoidal blocks as a screening method for nasal polyps in autopsy material. Rhinology 1995;33:185-8.
  • Settipane GA. Epidemiology of nasal polyps. Allergy Asthma Proc 1996;17:231-6.
  • Bernstein JM, Kansal R. Superantigen hypothesis for the early development of chronic hyperplastic sinusitis with massive nasal polyposis. Curr Opin Otolaryngol Head Neck Surg 2005;13:39-44.
  • Van Zele T, Gevaert P, Watelet JB, Claeys G, Holtappels G, Claeys C, et al. Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis. J Allergy Clin Immunol 2004;114:981-3.
  • Conley DB, Tripathi A, Ditto AM, Reid K, Grammer LC, Kern RC. Chronic sinusitis with nasal polyps: staphylococcal exotoxin immunoglobulin E and cellular inflammation. Am J Rhinol 2004;18:273-8.
  • Gevaert P, Holtappels G, Johansson SG, Cuvelier C, Cauwenberge P, Bachert C. Organization of secondary lymphoid tissue and local IgE formation to Staphylococcus aureus enterotoxins in nasal polyp tissue. Allergy 2005;60:71-9.
  • Arruda-Olson AM, Reeder GS, Bell MR, Weston SA, Roger VL. Neutrophilia predicts death and heart failure after myocardial infarction: a community- based study. Circ Cardiovasc Qual Outcomes 2009;2:656-62.
  • Rudiger A, Burckhardt OA, Harpes P, Müller SA, Follath F. The relative lymphocyte count on hospital admission is a risk factor for long-term mortality in patients with acute heart failure. Am J Emerg Med 2006;24:451-4.
  • Nşñez J, Nşñez E, Bodí V, Sanchis J, Miñana G, Mainar L, et al. Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction. Am J Cardiol 2008;101:747-52
  • Walsh SR, Cook EJ, Goulder F, Justin TA, Keeling NJ. Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer. J Surg Oncol 2005;91:181-4.
  • Sarraf KM, Belcher E, Raevsky E, Nicholson AG, Goldstraw P, Lim E. Neutrophil/lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancer. J Thorac Cardiovasc Surg 2009;137:425-8.
  • Turkmen K, Guney I, Yerlikaya FH, Tonbul HZ. The relationship between neutrophil-to-lymphocyte ratio and inflammation in end-stage renal disease patients. Ren Fail 2012;34:155-9.
  • Kuyumcu ME, Yesil Y, Oztürk ZA, Kizilarslanoğlu C, Etgül S, Halil M, et al. The evaluation of neutrophil- lymphocyte ratio in Alzheimer's disease. Dement Geriatr Cogn Disord 2012;34:69-74.
  • Wittekindt C, Hess A, Bloch W, Sultanie S, Michel O. Immunohistochemical expression of VEGF and VEGF receptors in nasal polyps as compared to normal turbinate mucosa. Eur Arch Otorhinolaryngol 2002;259:294-8.
  • Wittekindt C, Hess A, Bloch W, Sultanie S, Michel O. Immunohistochemical expression of VEGF and VEGF receptors in nasal polyps as compared to normal turbinate mucosa. Eur Arch Otorhinolaryngol 2002;259:294-8.
  • Vogel M, Miescher S, Biaggi C, Stadler BM. Human anti-IgE antibodies by repertoire cloning. Eur J Immunol 1994;24:1200-7.
  • Di Lorenzo G, Drago A, Esposito Pellitteri M, Candore G, Colombo A, Gervasi F, et al. Measurement of inflammatory mediators of mast cells and eosinophils in native nasal lavage fluid in nasal polyposis. Int Arch Allergy Immunol 2001;125:164-75.
  • Matsuwaki Y, Ookushi T, Asaka D, Mori E, Nakajima T, Yoshida T, et al. Chronic rhinosinusitis: risk factors for the recurrence of chronic rhinosinusitis based on 5-year follow-up after endoscopic sinus surgery. Int Arch Allergy Immunol 2008;146:77-81.
  • Stammberger H. Surgical treatment of nasal polyps: past, present, and future. Allergy 1999;54 Suppl 53:7-11.
  • Delbrouck C, Gabius HJ, Vandenhoven G, Kiss R, Hassid S. Budesonide-dependent modulation of expression of macrophage migration inhibitory factor in a polyposis model: evidence for differential regulation in surface and glandular epithelia. Ann Otol Rhinol Laryngol 2004;113:544-51.
There are 36 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Alper Yenigün This is me

Publication Date September 25, 2015
Published in Issue Year 2015 Volume: 25 Issue: 4

Cite

APA Yenigün, A. (2015). Assessment of patients with nasal polyposis by the neutrophil-to-lymphocyte ratio and eosinophil-to-lymphocyte ratio. The Turkish Journal of Ear Nose and Throat, 25(4), 193-199.
AMA Yenigün A. Assessment of patients with nasal polyposis by the neutrophil-to-lymphocyte ratio and eosinophil-to-lymphocyte ratio. Tr-ENT. September 2015;25(4):193-199.
Chicago Yenigün, Alper. “Assessment of Patients With Nasal Polyposis by the Neutrophil-to-Lymphocyte Ratio and Eosinophil-to-Lymphocyte Ratio”. The Turkish Journal of Ear Nose and Throat 25, no. 4 (September 2015): 193-99.
EndNote Yenigün A (September 1, 2015) Assessment of patients with nasal polyposis by the neutrophil-to-lymphocyte ratio and eosinophil-to-lymphocyte ratio. The Turkish Journal of Ear Nose and Throat 25 4 193–199.
IEEE A. Yenigün, “Assessment of patients with nasal polyposis by the neutrophil-to-lymphocyte ratio and eosinophil-to-lymphocyte ratio”, Tr-ENT, vol. 25, no. 4, pp. 193–199, 2015.
ISNAD Yenigün, Alper. “Assessment of Patients With Nasal Polyposis by the Neutrophil-to-Lymphocyte Ratio and Eosinophil-to-Lymphocyte Ratio”. The Turkish Journal of Ear Nose and Throat 25/4 (September 2015), 193-199.
JAMA Yenigün A. Assessment of patients with nasal polyposis by the neutrophil-to-lymphocyte ratio and eosinophil-to-lymphocyte ratio. Tr-ENT. 2015;25:193–199.
MLA Yenigün, Alper. “Assessment of Patients With Nasal Polyposis by the Neutrophil-to-Lymphocyte Ratio and Eosinophil-to-Lymphocyte Ratio”. The Turkish Journal of Ear Nose and Throat, vol. 25, no. 4, 2015, pp. 193-9.
Vancouver Yenigün A. Assessment of patients with nasal polyposis by the neutrophil-to-lymphocyte ratio and eosinophil-to-lymphocyte ratio. Tr-ENT. 2015;25(4):193-9.