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Multiple primary malignant paraganglioma of the head and neck with lymph node metastasis

Year 2015, Volume: 25 Issue: 4, 232 - 236, 25.09.2015

Abstract

Paragangliomas of the head and neck are usually benign tumors. Malignant form is quite rare and criteria for malignancy are not clear. Clinical, biochemical and histological features of malignant forms are not sufficient to reliably distinguish them from benign tumors and malignancy is established only in the presence of distant metastasis. Herein, we report a patient with glomus jugulare on the right, glomus vagale and glomus caroticum tumors on the left side with cervical lymph node metastasis on the right side.

References

  • Faggiano A, Mansueto G, Ferolla P, Milone F, del Basso de Caro ML, Lombardi G, et al. Diagnostic and prognostic implications of the World Health Organization classification of neuroendocrine tumors. J Endocrinol Invest 2008;31:216-23.
  • Brewis C, Bottrill ID, Wharton SB, Moffat DA. Glomus jugulare tumour with metastases to cervical lymph nodes. J Laryngol Otol 2000;114:67-9.
  • Lee JH, Barich F, Karnell LH, Robinson RA, Zhen WK, Gantz BJ, et al. National Cancer Data Base report on malignant paragangliomas of the head and neck. Cancer 2002;94:730-7.
  • Hall TC, Renwick P, Stafford ND. Recurrent familial malignant carotid body tumour presenting with lymph node metastasis: case report, and review of diagnosis and management of familial carotid body tumours. J Laryngol Otol 2010;124:1344-6.
  • Young AL, Baysal BE, Deb A, Young WF Jr. Familial malignant catecholamine-secreting paraganglioma with prolonged survival associated with mutation in the succinate dehydrogenase B gene. J Clin Endocrinol Metab 2002;87:4101-5. 6. Mediouni A, Ammari S, Wassef M, Gimenez-Roqueplo AP, Laredo JD, Duet M, et al. Malignant head/neck paragangliomas. Comparative study. Eur Ann Otorhinolaryngol Head Neck Dis 2014;131:159-66.
  • Amar L, Baudin E, Burnichon N, Peyrard S, Silvera S, Bertherat J, et al. Succinate dehydrogenase B gene mutations predict survival in patients with malignant pheochromocytomas or paragangliomas. J Clin Endocrinol Metab 2007;92:3822-8.
  • Klein RD, Jin L, Rumilla K, Young WF Jr, Lloyd RV. Germline SDHB mutations are common in patients with apparently sporadic sympathetic paragangliomas. Diagn Mol Pathol 2008;17:94-100.
  • Kwekkeboom DJ, van Urk H, Pauw BK, Lamberts SW, Kooij PP, Hoogma RP, et al. Octreotide scintigraphy for the detection of paragangliomas. J Nucl Med 1993;34:873-8.
  • Safford SD, Coleman RE, Gockerman JP, Moore J, Feldman JM, Leight GS Jr, et al. Iodine -131 metaiodobenzylguanidine is an effective treatment for malignant pheochromocytoma and paraganglioma. Surgery 2003;134:956-62.
  • Tonyukuk V, Emral R, Temizkan S, Sertçelik A, Erden I, Corapçioğlu D. Case report: patient with multiple paragangliomas treated with long acting somatostatin analogue. Endocr J 2003;50:507-13.

Lenf nodu metastazlı baş ve boynun çoklu primer malign paragangliyoması

Year 2015, Volume: 25 Issue: 4, 232 - 236, 25.09.2015

Abstract

Baş ve boyun paragangliomaları genellikle benign tümörlerdir. Malign form son derece seyrek olup malignite kriterleri açık değildir. Malign formların klinik, biyokimyasal ve histolojik özellikleri onları benign formdan ayırt etmek için yeterli değildir ve malignite ancak uzak metastaz olduğunda saptanabilir. Bu yazıda sağ tarafta glomus jugulare, sol tarafta glomus vagale ve glomus karotikum tümörleri olup sağ tarafta boyun lenf nodu metastazı gösteren bir hasta sunuldu

References

  • Faggiano A, Mansueto G, Ferolla P, Milone F, del Basso de Caro ML, Lombardi G, et al. Diagnostic and prognostic implications of the World Health Organization classification of neuroendocrine tumors. J Endocrinol Invest 2008;31:216-23.
  • Brewis C, Bottrill ID, Wharton SB, Moffat DA. Glomus jugulare tumour with metastases to cervical lymph nodes. J Laryngol Otol 2000;114:67-9.
  • Lee JH, Barich F, Karnell LH, Robinson RA, Zhen WK, Gantz BJ, et al. National Cancer Data Base report on malignant paragangliomas of the head and neck. Cancer 2002;94:730-7.
  • Hall TC, Renwick P, Stafford ND. Recurrent familial malignant carotid body tumour presenting with lymph node metastasis: case report, and review of diagnosis and management of familial carotid body tumours. J Laryngol Otol 2010;124:1344-6.
  • Young AL, Baysal BE, Deb A, Young WF Jr. Familial malignant catecholamine-secreting paraganglioma with prolonged survival associated with mutation in the succinate dehydrogenase B gene. J Clin Endocrinol Metab 2002;87:4101-5. 6. Mediouni A, Ammari S, Wassef M, Gimenez-Roqueplo AP, Laredo JD, Duet M, et al. Malignant head/neck paragangliomas. Comparative study. Eur Ann Otorhinolaryngol Head Neck Dis 2014;131:159-66.
  • Amar L, Baudin E, Burnichon N, Peyrard S, Silvera S, Bertherat J, et al. Succinate dehydrogenase B gene mutations predict survival in patients with malignant pheochromocytomas or paragangliomas. J Clin Endocrinol Metab 2007;92:3822-8.
  • Klein RD, Jin L, Rumilla K, Young WF Jr, Lloyd RV. Germline SDHB mutations are common in patients with apparently sporadic sympathetic paragangliomas. Diagn Mol Pathol 2008;17:94-100.
  • Kwekkeboom DJ, van Urk H, Pauw BK, Lamberts SW, Kooij PP, Hoogma RP, et al. Octreotide scintigraphy for the detection of paragangliomas. J Nucl Med 1993;34:873-8.
  • Safford SD, Coleman RE, Gockerman JP, Moore J, Feldman JM, Leight GS Jr, et al. Iodine -131 metaiodobenzylguanidine is an effective treatment for malignant pheochromocytoma and paraganglioma. Surgery 2003;134:956-62.
  • Tonyukuk V, Emral R, Temizkan S, Sertçelik A, Erden I, Corapçioğlu D. Case report: patient with multiple paragangliomas treated with long acting somatostatin analogue. Endocr J 2003;50:507-13.
There are 10 citations in total.

Details

Primary Language English
Journal Section Case Report
Authors

Sertaç Yetişer This is me

Saime Ramadan This is me

Publication Date September 25, 2015
Published in Issue Year 2015 Volume: 25 Issue: 4

Cite

APA Yetişer, S., & Ramadan, S. (2015). Multiple primary malignant paraganglioma of the head and neck with lymph node metastasis. The Turkish Journal of Ear Nose and Throat, 25(4), 232-236.
AMA Yetişer S, Ramadan S. Multiple primary malignant paraganglioma of the head and neck with lymph node metastasis. Tr-ENT. September 2015;25(4):232-236.
Chicago Yetişer, Sertaç, and Saime Ramadan. “Multiple Primary Malignant Paraganglioma of the Head and Neck With Lymph Node Metastasis”. The Turkish Journal of Ear Nose and Throat 25, no. 4 (September 2015): 232-36.
EndNote Yetişer S, Ramadan S (September 1, 2015) Multiple primary malignant paraganglioma of the head and neck with lymph node metastasis. The Turkish Journal of Ear Nose and Throat 25 4 232–236.
IEEE S. Yetişer and S. Ramadan, “Multiple primary malignant paraganglioma of the head and neck with lymph node metastasis”, Tr-ENT, vol. 25, no. 4, pp. 232–236, 2015.
ISNAD Yetişer, Sertaç - Ramadan, Saime. “Multiple Primary Malignant Paraganglioma of the Head and Neck With Lymph Node Metastasis”. The Turkish Journal of Ear Nose and Throat 25/4 (September 2015), 232-236.
JAMA Yetişer S, Ramadan S. Multiple primary malignant paraganglioma of the head and neck with lymph node metastasis. Tr-ENT. 2015;25:232–236.
MLA Yetişer, Sertaç and Saime Ramadan. “Multiple Primary Malignant Paraganglioma of the Head and Neck With Lymph Node Metastasis”. The Turkish Journal of Ear Nose and Throat, vol. 25, no. 4, 2015, pp. 232-6.
Vancouver Yetişer S, Ramadan S. Multiple primary malignant paraganglioma of the head and neck with lymph node metastasis. Tr-ENT. 2015;25(4):232-6.