Rhino-orbito-cerebral mucormycosis: two case reports in the light of the literature

Year 2015, Volume: 25 Issue: 5, 295 - 301, 10.10.2015

Medine Kara Halil Erdoğan Tolgahan Toroslu Alper Akçalı Müşerref Tatman Okun Mustafa Reşorlu Fevzi Sefa Dereköy

Abstract

Rhino-orbito-cerebral mucormycosis is an acute onset and often fatal disease. Risk factors include uncontrolled diabetes mellitus, hematological malignancies, and long-term corticosteroid use. Early diagnosis and treatment are important. The underlying causes should be treated, surgical debridement should be performed and appropriate antifungal drugs should be given. In this article, we report two diabetic ketoacidosis patients who developed rhino-orbito-cerebral mucormycosis and were treated with surgical debridement and amphotericin B therapy.

Keywords

Amphotericin B, rhino-orbito-cerebral mucormycosis, rhizomucor, surgical debridement

Rino-orbito-serebral mukormikozis: Literatür eşliğinde iki olgu sunumu

Abstract

Rino-orbito-serebral mukormikozis akut başlayan ve sıklıkla ölümcül olan bir hastalıktır. Risk faktörleri arasında kontrolsüz diyabetes mellitus, hematolojik maligniteler ve uzun süreli kortikosteroid kullanımı yer alır. Erken tanı ve tedavi önemlidir. Altta yatan nedenler tedavi edilmeli, cerrahi debridman yapılmalı ve uygun antifungal ilaçlar verilmelidir. Bu yazıda rino-orbito-serebral mukormikozis gelişen, cerrahi debridman ve amfoterisin B terapisi ile tedavi edilen iki diyabetik ketoasidoz hastası sunuldu

Keywords

Amfoterisin B, rino-orbito-serebral mukormikozis, rhizomucor, cerrahi debridman

References

• Teixeira CA, Medeiros PB, Leushner P, Almeida F. Rhinocerebral mucormycosis: literature review apropos of a rare entity. BMJ Case Rep 2013;2013.
• González Ballester D, González-García R, Moreno García C, Ruiz-Laza L, Monje Gil F. Mucormycosis of the head and neck: report of five cases with different presentations. J Craniomaxillofac Surg 2012;40:584-91.
• Dan M. Mucormycosis of the head and neck. Curr Infect Dis Rep 2011;13:123-31.
• Hosseini SM, Borghei P. Rhinocerebral mucormycosis: pathways of spread. Eur Arch Otorhinolaryngol 2005;262:932-8.
• Koc Z, Koc F, Yerdelen D, Ozdogu H. Rhino- orbital-cerebral mucormycosis with different cerebral involvements: infarct, hemorrhage, and ophthalmoplegia. Int J Neurosci 2007;117:1677-90.
• Mallis A, Mastronikolis SN, Naxakis SS, Papadas AT. Rhinocerebral mucormycosis: an update. Eur Rev Med Pharmacol Sci 2010;14:987-92.
• Ammari L, Kilani B, Tiouiri H, Kanoun F, Goubontini A, Mnif E, et al. Mucormycosis: four case reports. Tunis Med 2008;86:165-8.
• Momeni AK, Roberts CC, Chew FS. Imaging of chronic and exotic sinonasal disease: review. AJR Am J Roentgenol 2007;189:35-45.
• Mathebula SD. Rhino-orbital mucormycosis. S Afr Optom 2006;65:78-81
• Shinde RV, Karande GS, Mohite ST, Patil SR. Rhino- orbital mucormycosis in diabetes mellitus. J Clin Diagn Res 2013;7:1145-7.
• Eucker J, Sezer O, Graf B, Possinger K. Mucormycoses. Mycoses 2001;44:253-60.
• Talmi YP, Goldschmied-Reouven A, Bakon M, Barshack I, Wolf M, Horowitz Z, et al. Rhino-orbital and rhino-orbito-cerebral mucormycosis. Otolaryngol Head Neck Surg 2002;127:22-31.
• Dai Y, Walker JW, Halloush RA, Khasawneh FA. Mucormycosis in two community hospitals and the role of infectious disease consultation: a case series. Int J Gen Med 2013;6:833-8.
• Toumi A, Larbi Ammari F, Loussaief C, Hadhri R, Ben Brahim H, Harrathi K, et al. Rhino-orbito-cerebral mucormycosis: five cases. Med Mal Infect 2012;42:591-8.
• Hosseini SM, Borghei P. Rhinocerebral mucormycosis: pathways of spread. Eur Arch Otorhinolaryngol 2005;262:932-8.
• Rumboldt Z, Castillo M. Indolent intracranial mucormycosis: case report. AJNR Am J Neuroradiol 2002;23:932-4.
• Hayat M, Mushtaq S, Saba S, Saif R. Rhino-orbital- mucormycosis as a presenting manifestation of gestational diabetes mellitus. Indian J Endocrinol Metab 2011;15:65-6.