Diagnosis and treatment of malignant lymphomas of parotid gland

Year 2015, Volume: 25 Issue: 6, 346 - 349, 30.12.2015

Neslihan Yaprak İsmail Cem Temel Alper Tunga Derin Kenan Güney

Abstract

Objectives: This study aims to report surgical outcomes of primary parotid lymphomas and to discuss the histopathological subtypes, incidence rates, and clinical course. Patients and Methods: Between January 2002 and December 2014, eight patients 2 males, 6 females; man age 46.6 years; range 25 to 60 years who were diagnosed with primary parotid lymphoma and underwent parotidectomy were retrospectively analyzed. Demographic characteristics of the patients, histopathological subtypes, disease stage, and survival rates were recorded. Results: The ratio of the patients diagnosed with lymphoma was 2.82% among all patients, while 18.1% of the malignancies were lymphomas. Fine needle aspiration biopsy was non-diagnostic. CD20-positive low-grade B-cell lymphoma was the most common histopathological subtype in 37.5% of the patients. Conclusion: Based on our study results, the fine needle aspiration biopsy is not helpful in the diagnosis of the lymphomas of the parotid gland. Although rarely seen, lymphomas of the parotid gland should be considered in the differential diagnosis.

Keywords

Parotid gland, primary parotid lymphoma, salivary gland neoplasm

Parotis bezi malign lenfomalarında tanı ve tedavi

Abstract

Amaç: Bu çalışmada primer parotis lenfomaların cerrahi sonuçları bildirildi ve histopatolojik alt tipleri, insidans oranları ve klinik seyri tartışıldı.Hastalar ve Yöntemler: Ocak 2002 - Aralık 2014 tarihleri arasında primer parotis lenfoma tanısı konulan ve parotidektomi yapılan sekiz hasta 2 erkek, 6 kadın; ort. yaş 46.6 yıl; dağılım 25-60 yıl retrospektif olarak incelendi. Hastaların demografik özellikleri, histopatolojik alttipleri, hastalık evresi ve sağkalım oranları kaydedildi.Bulgular: Lenfoma tanısı konulan hastaların tüm hastalar içerisindeki oranı %2.82 olup malign olguların %18.1’ini lenfomalar oluşturdu. İnce iğne aspirasyon biyopsisi tanısal değildi. CD20 pozitif düşük grade B hücreli lenfoma, hastaların %37.5’inde en sık görülen histopatolojik alt tip idi.Sonuç: Çalışma sonuçlarımıza göre, ince iğne aspirasyon biyopsisi parotis bezi lenfomalarının tanısında yardımcı değildir. Nadir görülmesine rağmen, parotis bezi lenfomaları ayırıcı tanıda göz önünde bulundurulmalıdır

Keywords

Parotis bezi, primer parotis lenfoma, tükürük bezi neoplazisi

References

• Cooper JS, Porter K, Mallin K, Hoffman HT, Weber RS, Ang KK, et al. National Cancer Database report on cancer of the head and neck: 10-year update. Head Neck 2009;31:748-58.
• Urquhart A, Berg R. Hodgkin's and non-Hodgkin's lymphoma of the head and neck. Laryngoscope 2001;111:1565-9.
• Tullio A, Marchetti C, Sesenna E, Brusati R, Cocchi R, Eusebi V. Treatment of carcinoma of the parotid gland: the results of a multicenter study. J Oral Maxillofac Surg 2001;59:263-70.
• Chi HS, Lee KW, Chiang FY, Tai CF, Wang LF, Yang SF, et al. Head and neck extranodal lymphoma in a single institute: a 17-year retrospective analysis. Kaohsiung J Med Sci 2012;28:435-41.
• von Stritzky M, Wereldsma JC, Pegels JG. Parotid mass as first symptom of a malignant lymphoma. J Surg Oncol 1998;67:25-7.
• Barnes L, Myers EN, Prokopakis EP. Primary malignant lymphoma of the parotid gland. Arch Otolaryngol Head Neck Surg 1998;124:573-7.
• Gleeson MJ, Bennett MH, Cawson RA. Lymphomas of salivary glands. Cancer 1986;58:699-704.
• Schmid U, Helbron D, Lennert K. Primary malignant lymphomas localized in salivary glands. Histopathology 1982;6:673-87.
• Sciubba JJ, Auclair PL, Ellis GL. Malignant lymphomas. In: Ellis GL, Auclair PL, Gnepp DR, editors. Surgical Pathology of the Salivary Glands. Philedelphia: W.B. Saunders Co; 1991. p. 528-43.
• Chan JK, Tsang WY, Hui PK, Ng CS, Sin VC, Khan SM, et al. T- and T/natural killer-cell lymphomas of the salivary gland: a clinicopathologic, immunohistochemical and molecular study of six cases. Hum Pathol 1997;28:238-45.
• Harris NL. Extranodal lymphoid infiltrates and mucosa-associated lymphoid tissue (MALT). A unifying concept. Am J Surg Pathol 1991;15:879-84.
• Takahashi H, Tsuda N, Tezuka F, Fujita S, Okabe H. Non-Hodgkin's lymphoma of the major salivary gland: a morphologic and immunohistochemical study of 15 cases. J Oral Pathol Med 1990;19:306-12.
• Tiplady CW, Taylor PR, White J, Arullendran P, Proctor SJ. Lymphoma presenting as a parotid tumour: a population-based study of diagnosis, treatment and outcome on behalf of the Scotland and Newcastle Lymphoma Group. Clin Oncol (R Coll Radiol) 2004;16:414-9.
• Feinstein AJ, Ciarleglio MM, Cong X, Otremba MD, Judson BL. Parotid gland lymphoma: prognostic analysis of 2140 patients. Laryngoscope 2013;123:1199-203.
• Schusterman MA, Granick MS, Erickson ER, Newton ED, Hanna DC, Bragdon RW. Lymphoma presenting as a salivary gland mass. Head Neck Surg 1988;10:411-5.
• Colby TV, Dorfman RF. Malignant lymphomas involving the salivary glands.Pathol Annu 1979;14:307-24.
• Voulgarelis M, Dafni UG, Isenberg DA, Moutsopoulos HM. Malignant lymphoma in primary Sjögren's syndrome: a multicenter, retrospective, clinical study by the European Concerted Action on Sjögren's Syndrome. Arthritis Rheum 1999;42:1765-72.
• Zenone T. Parotid gland non-Hodgkin lymphoma in primary Sjögren syndrome. Rheumatol Int 2012;32:1387-90.
• National Cancer Institute sponsored study of classifications of non-Hodgkin’s lymphomas: summary and description of a working formulation for clinical usage. The Non-Hodgkin’s Lymphoma Pathologic Classification Project. Cancer 1982;49:2112-35.
• Herrinton LJ. Epidemiology of the Revised European- American Lymphoma Classification subtypes. Epidemiol Rev 1998;20:187-203.
• Huvos AG, Paulino AF. Salivary glands. In: Mills SE, Carter D, Reuter VE, editors. Sternberg’s Diagnostic Surgical Pathologyb, 4th ed. Philedelphia: Lippincott & Williams Wilkins; 2004. p. 933-62.