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The impact of preepiglottic space invasion on cervical lymph node metastases in open supraglottic laryngectomy revisited

Year 2017, Volume: 27 Issue: 2, 84 - 90, 18.06.2017

Abstract

Objectives: This study aims to evaluate the relationship between presence of preepiglottic space PES invasion and cervical nodal metastasis and their impact on disease free survival. Patients and Methods: This retrospective cohort study included 49 patients 45 males, 4 females; mean age 65 years; range 49 to 87 years who underwent open supraglottic laryngectomy with bilateral neck dissection. The study was conducted between January 2007 and January 2016. The background information was retrieved from patients’ files. The collected data were used to assess the association between PES invasion and other possible prognostic factors. Results: There was a statistically significant relationship between PES invasion and ipsilateral nodal metastasis p=0.001 . Disease free survival rate was significantly higher in patients with no PES invasion p=0.033 but not in those with nodal metastasis. Conclusion: Open supraglottic partial laryngectomy is an oncologically safe procedure that can be used in patients with early and selected advanced stage supraglottic carcinoma. Since PES invasion is a significant risk factor that causes poor prognosis, it should be rigorously evaluated via different imaging modalities before treatment.

References

  • Mor N, Blitzer A. Functional Anatomy and Oncologic Barriers of the Larynx. Otolaryngol Clin North Am 2015;48:533-45.
  • Armstrong WB, Vokes DE, Maisel RH. Cummings Otolaryngology Head & Neck Surgery. In: Haughey BH, Robins KT, editor. Malignant Tumors of the Larynx. 5th ed. Philadelphia: Mosby Elsevier; 2010. p. 1482-84.
  • Joo YH, Park JO, Cho KJ, Kim MS. Relationship between preepiglottic space invasion and lymphatic metastasis in supracricoid partial laryngectomy with cricohyoidopexy. Clin Exp Otorhinolaryngol 2014;7:205-9.
  • Rapoport A, Botelho RA, Souza RP, Cavalcanti SM, Furlam S, Tornin Ode S, et al. The importance of pre-epiglottis space invasion in the treatment planning of larynx and hypopharynx cancer. Braz J Otorhinolaryngol 2008;74:74-8.
  • Gregor RT. The preepiglottic space revisited: is it significant? Am J Otolaryngol 1990;11:161-4.
  • Dursun G, Keser R, Aktürk T, Akìner MN, Demireller A, Sak SD. The significance of pre-epiglottic space invasion in supraglottic laryngeal carcinomas. Eur Arch Otorhinolaryngol 1997;254:110-2.
  • Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti AI. AJCC Cancer Staging Manual. 7th ed. New York: Springer; 2009.
  • Suoglu Y, Guven M, Kiyak E, Enoz M. Significance of pre-epiglottic space invasion in supracricoid partial laryngectomy with cricohyoidopexy. J Laryngol Otol 2008;122:623-7.
  • Hicks WL Jr, Kollmorgen DR, Kuriakose MA, Orner J, Bakamjian VY, Winston J, et al. Patterns of nodal metastasis and surgical management of the neck in supraglottic laryngeal carcinoma. Otolaryngol Head Neck Surg 1999;121:57-61.
  • Maurizi M, Paludetti G, Galli J, Ottaviani F, D'Abramo G, Almadori G. Oncological and functional outcome of conservative surgery for primary supraglottic cancer. Eur Arch Otorhinolaryngol 1999;256:283-90.
  • Succo G, Peretti G, Piazza C, Remacle M, Eckel HE, Chevalier D, et al. Open partial horizontal laryngectomies: a proposal for classification by the working committee on nomenclature of the European Laryngological Society. Eur Arch Otorhinolaryngol 2014;271:2489-96.
  • Succo G, Crosetti E, Bertolin A, Lucioni M, Caracciolo A, Panetta V, et al. Benefits and drawbacks of open partial horizontal laryngectomies, Part A: Early- to intermediate-stage glottic carcinoma. Head Neck 2016;38:333-40.
  • Succo G, Crosetti E, Bertolin A, Lucioni M, Arrigoni G, Panetta V, et al. Benefits and drawbacks of open partial horizontal laryngectomies, Part B: Intermediate and selected advanced stage laryngeal carcinoma. Head Neck 2016;38:649-57.
  • Bron LP, Soldati D, Monod ML, Mégevand C, Brossard E, Monnier P, et al. Horizontal partial laryngectomy for supraglottic squamous cell carcinoma. Eur Arch Otorhinolaryngol 2005;262:302-6.
  • Maurizi M, Paludetti G, Galli J, Ottaviani F, D’Abramo G, Almadori G. Oncological and functional outcome of conservative surgery for primary supraglottic cancer. Eur Arch Otorhinolaryngol 1999;256:283-90.
  • Hermans R, Van den Bogaert W, Rijnders A, Baert AL. Value of computed tomography as outcome predictor of supraglottic squamous cell carcinoma treated by definitive radiation therapy. Int J Radiat Oncol Biol Phys 1999;44:755-65.
  • Werner JA, Dünne AA, Myers JN. Functional anatomy of the lymphatic drainage system of the upper aerodigestive tract and its role in metastasis of squamous cell carcinoma. Head Neck 2003;25:322-32.
  • Zeitels SM, Vaughan CW. Preepiglottic space invasion in "early" epiglottic cancer. Ann Otol Rhinol Laryngol 1991;100:789-92.
  • Fiorella R, Di Nicola V, Resta L, Russo S. Invasion of the thyro-hyoid-epiglottic space by carcinoma of the vestibulum laryngis: prognostic and therapeutic implications. Acta Otorhinolaryngol Ital 1991;11:329-37. [Abstract]
  • Ljumanović R, Langendijk JA, Schenk B, Van Wattingen M, Knol DL, Leemans CR, et al. Supraglottic carcinoma treated with curative radiation therapy: identification of prognostic groups with MR imaging. Radiology 2004;232:440-8.
  • Becker M, Burkhardt K, Dulguerov P, Allal A. Imaging of the larynx and hypopharynx. Eur J Radiol 2008;66:460-79.

Açık supraglottik larenjektomide preepiglottik alan invazyonunun servikal lenf nodu metastazları üzerine etkisinin gözden geçirilmesi

Year 2017, Volume: 27 Issue: 2, 84 - 90, 18.06.2017

Abstract

Amaç: Bu çalışmada preepiglottik alan PEA invazyonu varlığı ve servikal nod metastazı arasındaki ilişki ve bunların hastalıksız sağkalım üzerindeki etkisi değerlendirildi.Hastalar ve Yöntemler: Bu retrospektif kohort çalışmaya iki taraflı boyun diseksiyonu ile açık supraglottik larenjektomi geçiren 49 hasta 45 erkek, 4 kadın; ort. yaş 65 yıl; dağılım 49-87 yıl dahil edildi. Çalışma Ocak 2007 - Ocak 2016 tarihleri arasında yapıldı. Geçmiş bilgisi hastaların dosyalarından edinildi. Toplanan veri PEA invazyonu ve diğer olası prognostik faktörler arasındaki ilişkiyi değerlendirmek için kullanıldı.Bulgular: Preepiglottik alan invazyonu ve aynı taraf nod metastazı arasında istatistiksel olarak anlamlı bir ilişki vardı p=0.001 . Preepiglottik alan invazyonu olmayan hastalarda hastalıksız sağkalım oranı anlamlı olarak daha yüksekti p=0.033 , fakat nod metastazı olanlarda anlamlı ilişki görülmedi.Sonuç: Açık supraglottik parsiyel larenjektomi erken ve seçilmiş ileri evre supraglottik karsinomlu hastalarda kullanılabilecek, onkolojik olarak güvenilir bir işlemdir. Preepiglottik alan invazyonu kötü prognoza yol açan önemli bir risk faktörü olduğundan, tedaviden önce farklı görüntüleme yöntemleri ile titizlikle değerlendirilmelidir

References

  • Mor N, Blitzer A. Functional Anatomy and Oncologic Barriers of the Larynx. Otolaryngol Clin North Am 2015;48:533-45.
  • Armstrong WB, Vokes DE, Maisel RH. Cummings Otolaryngology Head & Neck Surgery. In: Haughey BH, Robins KT, editor. Malignant Tumors of the Larynx. 5th ed. Philadelphia: Mosby Elsevier; 2010. p. 1482-84.
  • Joo YH, Park JO, Cho KJ, Kim MS. Relationship between preepiglottic space invasion and lymphatic metastasis in supracricoid partial laryngectomy with cricohyoidopexy. Clin Exp Otorhinolaryngol 2014;7:205-9.
  • Rapoport A, Botelho RA, Souza RP, Cavalcanti SM, Furlam S, Tornin Ode S, et al. The importance of pre-epiglottis space invasion in the treatment planning of larynx and hypopharynx cancer. Braz J Otorhinolaryngol 2008;74:74-8.
  • Gregor RT. The preepiglottic space revisited: is it significant? Am J Otolaryngol 1990;11:161-4.
  • Dursun G, Keser R, Aktürk T, Akìner MN, Demireller A, Sak SD. The significance of pre-epiglottic space invasion in supraglottic laryngeal carcinomas. Eur Arch Otorhinolaryngol 1997;254:110-2.
  • Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti AI. AJCC Cancer Staging Manual. 7th ed. New York: Springer; 2009.
  • Suoglu Y, Guven M, Kiyak E, Enoz M. Significance of pre-epiglottic space invasion in supracricoid partial laryngectomy with cricohyoidopexy. J Laryngol Otol 2008;122:623-7.
  • Hicks WL Jr, Kollmorgen DR, Kuriakose MA, Orner J, Bakamjian VY, Winston J, et al. Patterns of nodal metastasis and surgical management of the neck in supraglottic laryngeal carcinoma. Otolaryngol Head Neck Surg 1999;121:57-61.
  • Maurizi M, Paludetti G, Galli J, Ottaviani F, D'Abramo G, Almadori G. Oncological and functional outcome of conservative surgery for primary supraglottic cancer. Eur Arch Otorhinolaryngol 1999;256:283-90.
  • Succo G, Peretti G, Piazza C, Remacle M, Eckel HE, Chevalier D, et al. Open partial horizontal laryngectomies: a proposal for classification by the working committee on nomenclature of the European Laryngological Society. Eur Arch Otorhinolaryngol 2014;271:2489-96.
  • Succo G, Crosetti E, Bertolin A, Lucioni M, Caracciolo A, Panetta V, et al. Benefits and drawbacks of open partial horizontal laryngectomies, Part A: Early- to intermediate-stage glottic carcinoma. Head Neck 2016;38:333-40.
  • Succo G, Crosetti E, Bertolin A, Lucioni M, Arrigoni G, Panetta V, et al. Benefits and drawbacks of open partial horizontal laryngectomies, Part B: Intermediate and selected advanced stage laryngeal carcinoma. Head Neck 2016;38:649-57.
  • Bron LP, Soldati D, Monod ML, Mégevand C, Brossard E, Monnier P, et al. Horizontal partial laryngectomy for supraglottic squamous cell carcinoma. Eur Arch Otorhinolaryngol 2005;262:302-6.
  • Maurizi M, Paludetti G, Galli J, Ottaviani F, D’Abramo G, Almadori G. Oncological and functional outcome of conservative surgery for primary supraglottic cancer. Eur Arch Otorhinolaryngol 1999;256:283-90.
  • Hermans R, Van den Bogaert W, Rijnders A, Baert AL. Value of computed tomography as outcome predictor of supraglottic squamous cell carcinoma treated by definitive radiation therapy. Int J Radiat Oncol Biol Phys 1999;44:755-65.
  • Werner JA, Dünne AA, Myers JN. Functional anatomy of the lymphatic drainage system of the upper aerodigestive tract and its role in metastasis of squamous cell carcinoma. Head Neck 2003;25:322-32.
  • Zeitels SM, Vaughan CW. Preepiglottic space invasion in "early" epiglottic cancer. Ann Otol Rhinol Laryngol 1991;100:789-92.
  • Fiorella R, Di Nicola V, Resta L, Russo S. Invasion of the thyro-hyoid-epiglottic space by carcinoma of the vestibulum laryngis: prognostic and therapeutic implications. Acta Otorhinolaryngol Ital 1991;11:329-37. [Abstract]
  • Ljumanović R, Langendijk JA, Schenk B, Van Wattingen M, Knol DL, Leemans CR, et al. Supraglottic carcinoma treated with curative radiation therapy: identification of prognostic groups with MR imaging. Radiology 2004;232:440-8.
  • Becker M, Burkhardt K, Dulguerov P, Allal A. Imaging of the larynx and hypopharynx. Eur J Radiol 2008;66:460-79.
There are 21 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Uygar Levent Demir This is me

Turgut Çevik This is me

Publication Date June 18, 2017
Published in Issue Year 2017 Volume: 27 Issue: 2

Cite

APA Demir, U. L., & Çevik, T. (2017). The impact of preepiglottic space invasion on cervical lymph node metastases in open supraglottic laryngectomy revisited. The Turkish Journal of Ear Nose and Throat, 27(2), 84-90.
AMA Demir UL, Çevik T. The impact of preepiglottic space invasion on cervical lymph node metastases in open supraglottic laryngectomy revisited. Tr-ENT. June 2017;27(2):84-90.
Chicago Demir, Uygar Levent, and Turgut Çevik. “The Impact of Preepiglottic Space Invasion on Cervical Lymph Node Metastases in Open Supraglottic Laryngectomy Revisited”. The Turkish Journal of Ear Nose and Throat 27, no. 2 (June 2017): 84-90.
EndNote Demir UL, Çevik T (June 1, 2017) The impact of preepiglottic space invasion on cervical lymph node metastases in open supraglottic laryngectomy revisited. The Turkish Journal of Ear Nose and Throat 27 2 84–90.
IEEE U. L. Demir and T. Çevik, “The impact of preepiglottic space invasion on cervical lymph node metastases in open supraglottic laryngectomy revisited”, Tr-ENT, vol. 27, no. 2, pp. 84–90, 2017.
ISNAD Demir, Uygar Levent - Çevik, Turgut. “The Impact of Preepiglottic Space Invasion on Cervical Lymph Node Metastases in Open Supraglottic Laryngectomy Revisited”. The Turkish Journal of Ear Nose and Throat 27/2 (June 2017), 84-90.
JAMA Demir UL, Çevik T. The impact of preepiglottic space invasion on cervical lymph node metastases in open supraglottic laryngectomy revisited. Tr-ENT. 2017;27:84–90.
MLA Demir, Uygar Levent and Turgut Çevik. “The Impact of Preepiglottic Space Invasion on Cervical Lymph Node Metastases in Open Supraglottic Laryngectomy Revisited”. The Turkish Journal of Ear Nose and Throat, vol. 27, no. 2, 2017, pp. 84-90.
Vancouver Demir UL, Çevik T. The impact of preepiglottic space invasion on cervical lymph node metastases in open supraglottic laryngectomy revisited. Tr-ENT. 2017;27(2):84-90.