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The effect of obstructive sleep apne syndrome and continuous positive airway pressure titration on stage 3 and REM sleeps

Year 2017, Volume: 27 Issue: 3, 141 - 145, 25.07.2017

Abstract

Objectives: This study aims to investigate the effect of disease severity and continuous positive airway pressure CPAP titration on stage 3 and rapid eye movement REM sleeps in obstructive sleep apnea syndrome OSAS patients. Patients and Methods: The study included 114 patients 87 males, 27 females; mean age 51.1±10.5 years; range 34 to 66 years who were diagnosed as moderate or severe OSAS with polysomnography PSG . Percentage values of apnea hypopnea index and sleep stages were individually statistically compared. Percentage values of sleep stages calculated during CPAP titration were determined and compared with first PSG. Results: According to the polysomnography result, of 114 patients, 41 were moderate 30 males, 11 females; mean age 49.8±10.2 years , 73 were severe 57 males, 16 females; mean age 51.8±10.8 years OSAS. As the apnea hypopnea index increased, stage 2 sleep increased, while stage 3 and REM sleeps decreased; changes were statistically significant p<0.001, p=0.002, p=0.002 . When the sleep stages detected during CPAP titration were compared to the first PSG, stage 3 sleep increased by 22% in moderate OSAS patients and by 45% in severe OSAS patients. While REM sleep did not increase in moderate OSAS patients, it increased by 28% in the severe OSAS patients. Conclusion: When an increase by 40% in stage 3 sleep and by 20% in REM sleep were accepted as rebound during CPAP titration, while there was no rebound at stage 3 and REM sleeps in moderate OSAS, rebound was observed at both stage 3 and REM sleeps in severe OSAS.

References

  • Patil SP, Schneider H, Schwartz AR, Smith PL. Adult obstructive sleep apnea: pathophysiology and diagnosis. Chest 2007;132:325-37.
  • Bozkuş F, Çilli A. Titrasyon gecesinde CPAP tedavisini reddeden hastalar. Turkiye Klinikleri Archives of Lung 2013;14:1-5.
  • Spicuzza L, Caruso D, Di Maria G. Obstructive sleep apnoea syndrome and its management. Ther Adv Chronic Dis 2015;6:273-85.
  • Aldrich M, Eiser A, Lee M, Shipley JE. Effects of continuous positive airway pressure on phasic events of REM sleep in patients with obstructive sleep apnea. Sleep 1989;12:413-9.
  • Brillante R, Cossa G, Liu PY, Laks L. Rapid eye movement and slow-wave sleep rebound after one night of continuous positive airway pressure for obstructive sleep apnoea. Respirology 2012;17:547-53.
  • Verma A, Radtke RA, VanLandingham KE, King JH, Husain AM. Slow wave sleep rebound and REM rebound following the first night of treatment with CPAP for sleep apnea: correlation with subjective improvement in sleep quality. Sleep Med 2001;2:215-223.
  • Issa FG, Sullivan CE. The immediate effects of nasal continuous positive airway pressure treatment on sleep pattern in patients with obstructive sleep apnea syndrome. Electroencephalogr Clin Neurophysiol 1986;63:10-7.
  • Zhang C, Lv J, Zhou J, Su L, Feng L, Ma J, et al. The effect of CPAP treatment on EEG of OSAS patients. Sleep Breath 2015;19:1121-4.
  • Lo Bue A, Salvaggio A, Insalaco G, Marrone O. Extreme REM Rebound during Continuous Positive Airway Pressure Titration for Obstructive Sleep Apnea in a Depressed Patient. Case Rep Med 2014;2014:292181.

Tıkayıcı uyku apne sendromunun ve sürekli pozitif havayolu basıncı titrasyonunun evre 3 ve REM uykusuna etkisi

Year 2017, Volume: 27 Issue: 3, 141 - 145, 25.07.2017

Abstract

Amaç: Bu çalışmada tıkayıcı uyku apnesi sendromu TUAS hastalarında hastalık şiddetinin ve sürekli pozitif havayolu basıncı SPHB titrasyonunun evre 3 ve REM rapid eye movement uykusu üzerine etkisi araştırıldı.Hastalar ve Yöntemler: Çalışmaya polisomnografi PSG ile orta veya ağır TUAS tanısı konulan 114 hasta 87 erkek, 27 kadın, ort. yaş 51.1±10.5 yıl; dağılım 34-66 yıl dahil edildi. Apne hipopne indeksi ve uyku evrelerinin yüzde değerleri ayrı ayrı istatistiksel olarak karşılaştırıldı. Sürekli pozitif havayolu basıncı titrasyonu sırasında hesaplanan uyku evrelerinin yüzde değerleri tespit edildi ve ilk PSG ile karşılaştırıldı.Bulgular: Polisomnografi sonucuna göre 114 hastanın 41’i orta 30 erkek, 11 kadın; ort. yaş 49.8±10.2 yıl , 73’ü ağır 57 erkek, 16 kadın; ort. yaş 51.8±10.8 yıl TUAS idi. Apne hipopne indeksi arttıkça evre 2 uykusu artarken, evre 3 ve REM uykusu azaldı; değişimler istatistiksel olarak anlamlı idi p

References

  • Patil SP, Schneider H, Schwartz AR, Smith PL. Adult obstructive sleep apnea: pathophysiology and diagnosis. Chest 2007;132:325-37.
  • Bozkuş F, Çilli A. Titrasyon gecesinde CPAP tedavisini reddeden hastalar. Turkiye Klinikleri Archives of Lung 2013;14:1-5.
  • Spicuzza L, Caruso D, Di Maria G. Obstructive sleep apnoea syndrome and its management. Ther Adv Chronic Dis 2015;6:273-85.
  • Aldrich M, Eiser A, Lee M, Shipley JE. Effects of continuous positive airway pressure on phasic events of REM sleep in patients with obstructive sleep apnea. Sleep 1989;12:413-9.
  • Brillante R, Cossa G, Liu PY, Laks L. Rapid eye movement and slow-wave sleep rebound after one night of continuous positive airway pressure for obstructive sleep apnoea. Respirology 2012;17:547-53.
  • Verma A, Radtke RA, VanLandingham KE, King JH, Husain AM. Slow wave sleep rebound and REM rebound following the first night of treatment with CPAP for sleep apnea: correlation with subjective improvement in sleep quality. Sleep Med 2001;2:215-223.
  • Issa FG, Sullivan CE. The immediate effects of nasal continuous positive airway pressure treatment on sleep pattern in patients with obstructive sleep apnea syndrome. Electroencephalogr Clin Neurophysiol 1986;63:10-7.
  • Zhang C, Lv J, Zhou J, Su L, Feng L, Ma J, et al. The effect of CPAP treatment on EEG of OSAS patients. Sleep Breath 2015;19:1121-4.
  • Lo Bue A, Salvaggio A, Insalaco G, Marrone O. Extreme REM Rebound during Continuous Positive Airway Pressure Titration for Obstructive Sleep Apnea in a Depressed Patient. Case Rep Med 2014;2014:292181.
There are 9 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Doğan Atan This is me

Kürşat Murat Özcan This is me

Nurcan Yurtsever Kum This is me

Hüseyin Dere This is me

Publication Date July 25, 2017
Published in Issue Year 2017 Volume: 27 Issue: 3

Cite

APA Atan, D., Özcan, K. M., Yurtsever Kum, N., Dere, H. (2017). Tıkayıcı uyku apne sendromunun ve sürekli pozitif havayolu basıncı titrasyonunun evre 3 ve REM uykusuna etkisi. The Turkish Journal of Ear Nose and Throat, 27(3), 141-145.
AMA Atan D, Özcan KM, Yurtsever Kum N, Dere H. Tıkayıcı uyku apne sendromunun ve sürekli pozitif havayolu basıncı titrasyonunun evre 3 ve REM uykusuna etkisi. Tr-ENT. July 2017;27(3):141-145.
Chicago Atan, Doğan, Kürşat Murat Özcan, Nurcan Yurtsever Kum, and Hüseyin Dere. “Tıkayıcı Uyku Apne Sendromunun Ve sürekli Pozitif Havayolu basıncı Titrasyonunun Evre 3 Ve REM Uykusuna Etkisi”. The Turkish Journal of Ear Nose and Throat 27, no. 3 (July 2017): 141-45.
EndNote Atan D, Özcan KM, Yurtsever Kum N, Dere H (July 1, 2017) Tıkayıcı uyku apne sendromunun ve sürekli pozitif havayolu basıncı titrasyonunun evre 3 ve REM uykusuna etkisi. The Turkish Journal of Ear Nose and Throat 27 3 141–145.
IEEE D. Atan, K. M. Özcan, N. Yurtsever Kum, and H. Dere, “Tıkayıcı uyku apne sendromunun ve sürekli pozitif havayolu basıncı titrasyonunun evre 3 ve REM uykusuna etkisi”, Tr-ENT, vol. 27, no. 3, pp. 141–145, 2017.
ISNAD Atan, Doğan et al. “Tıkayıcı Uyku Apne Sendromunun Ve sürekli Pozitif Havayolu basıncı Titrasyonunun Evre 3 Ve REM Uykusuna Etkisi”. The Turkish Journal of Ear Nose and Throat 27/3 (July 2017), 141-145.
JAMA Atan D, Özcan KM, Yurtsever Kum N, Dere H. Tıkayıcı uyku apne sendromunun ve sürekli pozitif havayolu basıncı titrasyonunun evre 3 ve REM uykusuna etkisi. Tr-ENT. 2017;27:141–145.
MLA Atan, Doğan et al. “Tıkayıcı Uyku Apne Sendromunun Ve sürekli Pozitif Havayolu basıncı Titrasyonunun Evre 3 Ve REM Uykusuna Etkisi”. The Turkish Journal of Ear Nose and Throat, vol. 27, no. 3, 2017, pp. 141-5.
Vancouver Atan D, Özcan KM, Yurtsever Kum N, Dere H. Tıkayıcı uyku apne sendromunun ve sürekli pozitif havayolu basıncı titrasyonunun evre 3 ve REM uykusuna etkisi. Tr-ENT. 2017;27(3):141-5.