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Evaluation of platelet indices in patients with deep neck space infection as a complication of acute tonsillitis

Year 2017, Volume: 27 Issue: 4, 179 - 184, 10.09.2017

Abstract

Objectives: This study aims to evaluate whether platelet indices are helpful to identify deep neck space infections DNSIs secondary to acute tonsillitis. Patients and Methods: A total of 321 patients diagnosed with acute tonsillitis with or without DNSI admitted to the Otolaryngology Department of Marmara University Pendik Training and Research Hospital between August 2010 and January 2014 were retrospectively reviewed. Patients underwent full otolaryngologic examination and radiological imaging studies including computed tomography CT or magnetic resonance imaging MRI in cases of suspected DNSI. Mean platelet volume MPV , platelet distribution width PDW , and platelet count PC were calculated in all subjects and these were compared between the patients with or without DNSI secondary to acute tonsillitis. Results: With respect to DNSI complications of tonsillitis, 25 of the patients had peritonsillar abscesses 7.8% , 11 had parapharyngeal abscesses 3.4% , and six had retropharyngeal abscesses 1.9% . The MPV, PDW, and PC values were significantly higher in patients with acute tonsillitis and DNSI p<0.05 . The optimum cut-off values for MPV, PDW, and PC were 8.75, 16.65, 278 and 500, respectively. Conclusion: This study is the first to evaluate the relationship between platelet indices and DNSI complications of acute tonsillitis. Our results demonstrate that MPV, PDW, and PC values are potential laboratory parameters for diagnosing DNSIs.

References

  • Brook I, Grimm S, Keibich RB. Bacteriology of acuteperiapical abscess in children. J Endodont 1981;7:378-80.
  • Brook I. Aerobic and anaerobic bacteriology of peritonsillarabscess in children. Acta Pediatr Scand 1981;70:831-38.
  • Brook I. Microbiology of retropharyngeal abscesses in children. Am J Dis Child 1987;141:202-4.
  • Brook I. The role of beta-lactamase-producing bacteria in the persistence of streptococcal tonsillar infection. Rev Infect Dis 1984;6:601-7.
  • Fasano CJ, Chudnofsky C, Vanderbeek P. Bilateral peritonsillar abscesses: not your usual sore throat. J Emerg Med 2005;29:45-7.
  • Rubin MA, Gonzales R, Sande MA. Pharyngitis, sinusitis, otitis and other upper respiratory tract infections. In: Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, et al., editors. Harrison’s Principles of Internal Medicine. 17th ed. New York: McGraw Hill Medical; 2008. p. 210-4.
  • Brochu B, Dubois J, Garel L, Quintal MC, Roy D. Complications of ENT infections: pseudoaneurysm of the internal carotid artery. Pediatr Radiol 2004;34:417-20.
  • Galer C, Holbrook E, Treves J, Leopold D. Grisel's syndrome: a case report and review of the literature. Int J Pediatr Otorhinolaryngol 2005;69:1689-92.
  • Ungkanont K, Yellon RF, Weissman JL, Casselbrant ML, González-Valdepeña H, Bluestone CD. Head and neck space infections in infants and children. Otolaryngol Head Neck Surg 1995;112:375-82.
  • Smyth SS, McEver RP, Weyrich AS, Morrell CN, Hoffman MR, Arepally GM, et al. Platelet functions beyond hemostasis. J Thromb Haemost 2009;7:1759- 66.
  • Yüksel O, Helvaci K, Başar O, Köklü S, Caner S, Helvaci N, et al. An overlooked indicator of disease activity in ulcerative colitis: mean platelet volume. Platelets 2009;20:277-81.
  • Endler G, Klimesch A, Sunder-Plassmann H, Schillinger M, Exner M, Mannhalter C, et al. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol 2002;117:399-404.
  • Mimidis K, Papadopoulos V, Kotsianidis J, Filippou D, Spanoudakis E, Bourikas G, et al. Alterations of platelet function, number and indexes during acute pancreatitis. Pancreatology 2004;4:22-7.
  • Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA, et al. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine 2008;75:291-4.
  • Tuncel T, Uysal P, Hocaoglu AB, Erge DO, Karaman O, Uzuner N. Change of mean platelet volume values in asthmatic children as an inflammatory marker. Allergol Immunopathol (Madr) 2012;40:104-7.
  • Somuk BT, Soyalıç H, Koc S, Gürbüzler L, Doğru S, Eyibilen A. Mean platelet volume as an inflammatory marker of chronic otitis media with effusion. Int J Pediatr Otorhinolaryngol 2014;78:1958-60.
  • Evsen MS, Soydinc HE, Sak ME, Ozler A, Turgut A, Celik Y, et al. Increased platelet count in severe peritoneal endometriosis. Clin Exp Obstet Gynecol 2014;41:423-5.
  • Seyyed-Mohammadzad MH, Khademvatani K, Kerachian A, Eskandari R, Rezaei Y. Slow coronary flow phenomenon and increased platelet volume indices. Korean Circ J. 2014;44:400-5.
  • Del Mar CB, Glasziou PP, Spinks AB. Antibiotics for sore throat. Cochrane Database Syst Rev 2000;4:000023.
  • Kamath S, Blann AD, Lip GY. Platelet activation: assessment and quantification. Eur Heart J 2001;22:1561-71.
  • Sato K, Liebeler CL, Quartey MK, Le CT, Giebink GS. Middle ear fluid cytokine and inflammatory cell kinetics in the chinchilla otitis media model. Infect Immun 1999;67:1943-6.
  • Tozkoparan E, Deniz O, Ucar E, Bilgic H, Ekiz K. Changes in platelet count and indices in pulmonary tuberculosis. Clin Chem Lab Med 2007;45:1009-13.
  • Vizioli L, Muscari S, Muscari A. The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases. Int J Clin Pract 2009;63:1509-15.
  • Yazici S, Yazici M, Erer B, Erer B, Calik Y, Bulur S, et al. The platelet functions in patients with ankylosing spondylitis: anti-TNF-alpha therapy decreases the mean platelet volume and platelet mass. Platelets 2010;21:126-31.
  • Gasparyan AY, Stavropoulos-Kalinoglou A, Toms TE, Douglas KM, Kitas GD. Association of mean platelet volume with hypertension in rheumatoid arthritis. Inflamm Allergy Drug Targets 2010;9:45-50.
  • Karabudak O, Ulusoy RE, Erikci AA, Solmazgul E, Dogan B, Harmanyeri Y. Inflammation and hypercoagulable state in adult psoriatic men. Acta Derm Venereol 2008;88:337-40.
  • Sansanayudh N, Numthavaj P, Muntham D, Yamwong S, McEvoy M, Attia J, et al. Prognostic effect of mean platelet volume in patients with coronary artery disease. A systematic review and meta-analysis. Thromb Haemost 2015;114:1299-309.
  • Yazici S, Yazici M, Erer B, Erer B, Calik Y, Ozhan H, et al. The platelet indices in patients with rheumatoid arthritis: mean platelet volume reflects disease activity. Platelets 2010;21:122-5.
  • Oncel MY, Ozdemir R, Yurttutan S, Canpolat FE, Erdeve O, Oguz SS, et al. Mean platelet volume in neonatal sepsis.J Clin Lab Anal 2012;26:493-6.
  • Ceylan B, Fincanci M, Yardimci C, Eren G, Tözalgan Ü, Müderrisoğlu C, et al. Can mean platelet volume determine the severity of liver fibrosis or inflammation in patients with chronic hepatitis B? Eur J Gastroenterol Hepatol 2013;25:606-12.
  • Tekin M, Konca C, Gulyuz A, Uckardes F, Turgut M. Is the mean platelet volume a predictive marker for the diagnosis of acute pyelonephritis in children? Clin Exp Nephrol 2015;19:688-93.
  • Gunebakmaz O, Kaya MG, Kaya EG, Ardic I, Yarlioglues M, Dogdu O, et al. Mean platelet volume predicts embolic complications and prognosis in infective endocarditis. Int J Infect Dis 2010;14:982-5.
  • Öztürk ZA, Dag MS, Kuyumcu ME, Cam H, Yesil Y, Yilmaz N, et al. Could platelet indices be new biomarkers for inflammatory bowel diseases? Eur Rev Med Pharmacol Sci 2013;17:334-41.
  • Gao Y, Li Y, Yu X, Guo S, Ji X, Sun T, et al. The impact of various platelet indices as prognostic markers of septic shock. PLoS One 2014;9:103761.
  • Kitazawa T, Yoshino Y, Tatsuno K, Ota Y, Yotsuyanagi H. Changes in the mean platelet volume levels after bloodstream infection have prognostic value. Intern Med 2013;52:1487-93.
  • Guclu E, Durmaz Y, Karabay O. Effect of severe sepsis on platelet count and their indices. Afr Health Sci 2013;13:333-8.

Bademcik iltihabı komplikasyonu olarak derin boyun enfeksiyonlu hastalarda trombosit indekslerinin değerlendirilmesi

Year 2017, Volume: 27 Issue: 4, 179 - 184, 10.09.2017

Abstract

Amaç: Bu çalışmada trombosit indekslerinin bademcik iltihabı sonrası derin boyun enfeksiyonu DBE tanımlamada yararlı olup olmadığı değerlendirildi.Hastalar ve Yöntemler: Ağustos 2010 - Ocak 2014 tarihleri arasında bademcik iltihabı tanısı ile DBE olan ve olmayan Marmara Üniversitesi Pendik Eğitim ve Araştırma Hastanesi Kulak Burun Boğaz Bölümü’ne başvuran toplam 321 hasta geriye dönük olarak incelendi. Hastalara, DBE şüphesi olan durumlarda bilgisayarlı tomografi BT veya manyetik rezonans görüntüleme MRI de dahil olmak üzere, tam kulak-burun-boğaz muayenesi ve radyolojik görüntüleme çalışmaları yapıldı. Tüm bireylerin ortalama trombosit hacmi OTH , trombosit dağılım genişliği TDG ve trombosit sayısı PC hesaplandı ve bademcik iltihabı sonrası DBE olan ile olmayan hastalar arasında karşılaştırıldı.Bulgular: Bademcik iltihabının DBE komplikasyonları ile ilgili olarak, hastaların 25’inde peritonsiller apse %7.8 , 11’inde parafarengeal apse %3.4 ve altısında retrofarengeal apse %1.9 vardı. OTH, TDG ve PC değerleri akut bademcik iltihabı ve DBE olan hastalarda belirgin olarak daha yüksekti p

References

  • Brook I, Grimm S, Keibich RB. Bacteriology of acuteperiapical abscess in children. J Endodont 1981;7:378-80.
  • Brook I. Aerobic and anaerobic bacteriology of peritonsillarabscess in children. Acta Pediatr Scand 1981;70:831-38.
  • Brook I. Microbiology of retropharyngeal abscesses in children. Am J Dis Child 1987;141:202-4.
  • Brook I. The role of beta-lactamase-producing bacteria in the persistence of streptococcal tonsillar infection. Rev Infect Dis 1984;6:601-7.
  • Fasano CJ, Chudnofsky C, Vanderbeek P. Bilateral peritonsillar abscesses: not your usual sore throat. J Emerg Med 2005;29:45-7.
  • Rubin MA, Gonzales R, Sande MA. Pharyngitis, sinusitis, otitis and other upper respiratory tract infections. In: Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, et al., editors. Harrison’s Principles of Internal Medicine. 17th ed. New York: McGraw Hill Medical; 2008. p. 210-4.
  • Brochu B, Dubois J, Garel L, Quintal MC, Roy D. Complications of ENT infections: pseudoaneurysm of the internal carotid artery. Pediatr Radiol 2004;34:417-20.
  • Galer C, Holbrook E, Treves J, Leopold D. Grisel's syndrome: a case report and review of the literature. Int J Pediatr Otorhinolaryngol 2005;69:1689-92.
  • Ungkanont K, Yellon RF, Weissman JL, Casselbrant ML, González-Valdepeña H, Bluestone CD. Head and neck space infections in infants and children. Otolaryngol Head Neck Surg 1995;112:375-82.
  • Smyth SS, McEver RP, Weyrich AS, Morrell CN, Hoffman MR, Arepally GM, et al. Platelet functions beyond hemostasis. J Thromb Haemost 2009;7:1759- 66.
  • Yüksel O, Helvaci K, Başar O, Köklü S, Caner S, Helvaci N, et al. An overlooked indicator of disease activity in ulcerative colitis: mean platelet volume. Platelets 2009;20:277-81.
  • Endler G, Klimesch A, Sunder-Plassmann H, Schillinger M, Exner M, Mannhalter C, et al. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol 2002;117:399-404.
  • Mimidis K, Papadopoulos V, Kotsianidis J, Filippou D, Spanoudakis E, Bourikas G, et al. Alterations of platelet function, number and indexes during acute pancreatitis. Pancreatology 2004;4:22-7.
  • Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA, et al. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine 2008;75:291-4.
  • Tuncel T, Uysal P, Hocaoglu AB, Erge DO, Karaman O, Uzuner N. Change of mean platelet volume values in asthmatic children as an inflammatory marker. Allergol Immunopathol (Madr) 2012;40:104-7.
  • Somuk BT, Soyalıç H, Koc S, Gürbüzler L, Doğru S, Eyibilen A. Mean platelet volume as an inflammatory marker of chronic otitis media with effusion. Int J Pediatr Otorhinolaryngol 2014;78:1958-60.
  • Evsen MS, Soydinc HE, Sak ME, Ozler A, Turgut A, Celik Y, et al. Increased platelet count in severe peritoneal endometriosis. Clin Exp Obstet Gynecol 2014;41:423-5.
  • Seyyed-Mohammadzad MH, Khademvatani K, Kerachian A, Eskandari R, Rezaei Y. Slow coronary flow phenomenon and increased platelet volume indices. Korean Circ J. 2014;44:400-5.
  • Del Mar CB, Glasziou PP, Spinks AB. Antibiotics for sore throat. Cochrane Database Syst Rev 2000;4:000023.
  • Kamath S, Blann AD, Lip GY. Platelet activation: assessment and quantification. Eur Heart J 2001;22:1561-71.
  • Sato K, Liebeler CL, Quartey MK, Le CT, Giebink GS. Middle ear fluid cytokine and inflammatory cell kinetics in the chinchilla otitis media model. Infect Immun 1999;67:1943-6.
  • Tozkoparan E, Deniz O, Ucar E, Bilgic H, Ekiz K. Changes in platelet count and indices in pulmonary tuberculosis. Clin Chem Lab Med 2007;45:1009-13.
  • Vizioli L, Muscari S, Muscari A. The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases. Int J Clin Pract 2009;63:1509-15.
  • Yazici S, Yazici M, Erer B, Erer B, Calik Y, Bulur S, et al. The platelet functions in patients with ankylosing spondylitis: anti-TNF-alpha therapy decreases the mean platelet volume and platelet mass. Platelets 2010;21:126-31.
  • Gasparyan AY, Stavropoulos-Kalinoglou A, Toms TE, Douglas KM, Kitas GD. Association of mean platelet volume with hypertension in rheumatoid arthritis. Inflamm Allergy Drug Targets 2010;9:45-50.
  • Karabudak O, Ulusoy RE, Erikci AA, Solmazgul E, Dogan B, Harmanyeri Y. Inflammation and hypercoagulable state in adult psoriatic men. Acta Derm Venereol 2008;88:337-40.
  • Sansanayudh N, Numthavaj P, Muntham D, Yamwong S, McEvoy M, Attia J, et al. Prognostic effect of mean platelet volume in patients with coronary artery disease. A systematic review and meta-analysis. Thromb Haemost 2015;114:1299-309.
  • Yazici S, Yazici M, Erer B, Erer B, Calik Y, Ozhan H, et al. The platelet indices in patients with rheumatoid arthritis: mean platelet volume reflects disease activity. Platelets 2010;21:122-5.
  • Oncel MY, Ozdemir R, Yurttutan S, Canpolat FE, Erdeve O, Oguz SS, et al. Mean platelet volume in neonatal sepsis.J Clin Lab Anal 2012;26:493-6.
  • Ceylan B, Fincanci M, Yardimci C, Eren G, Tözalgan Ü, Müderrisoğlu C, et al. Can mean platelet volume determine the severity of liver fibrosis or inflammation in patients with chronic hepatitis B? Eur J Gastroenterol Hepatol 2013;25:606-12.
  • Tekin M, Konca C, Gulyuz A, Uckardes F, Turgut M. Is the mean platelet volume a predictive marker for the diagnosis of acute pyelonephritis in children? Clin Exp Nephrol 2015;19:688-93.
  • Gunebakmaz O, Kaya MG, Kaya EG, Ardic I, Yarlioglues M, Dogdu O, et al. Mean platelet volume predicts embolic complications and prognosis in infective endocarditis. Int J Infect Dis 2010;14:982-5.
  • Öztürk ZA, Dag MS, Kuyumcu ME, Cam H, Yesil Y, Yilmaz N, et al. Could platelet indices be new biomarkers for inflammatory bowel diseases? Eur Rev Med Pharmacol Sci 2013;17:334-41.
  • Gao Y, Li Y, Yu X, Guo S, Ji X, Sun T, et al. The impact of various platelet indices as prognostic markers of septic shock. PLoS One 2014;9:103761.
  • Kitazawa T, Yoshino Y, Tatsuno K, Ota Y, Yotsuyanagi H. Changes in the mean platelet volume levels after bloodstream infection have prognostic value. Intern Med 2013;52:1487-93.
  • Guclu E, Durmaz Y, Karabay O. Effect of severe sepsis on platelet count and their indices. Afr Health Sci 2013;13:333-8.
There are 36 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Adem Binnetoğlu This is me

Ali Cemal Yumuşakhuylu This is me

Tekin Bağlam This is me

Berat Demir This is me

Fethullah Gerin This is me

Murat Sarı This is me

Publication Date September 10, 2017
Published in Issue Year 2017 Volume: 27 Issue: 4

Cite

APA Binnetoğlu, A., Yumuşakhuylu, A. C., Bağlam, T., Demir, B., et al. (2017). Evaluation of platelet indices in patients with deep neck space infection as a complication of acute tonsillitis. The Turkish Journal of Ear Nose and Throat, 27(4), 179-184.
AMA Binnetoğlu A, Yumuşakhuylu AC, Bağlam T, Demir B, Gerin F, Sarı M. Evaluation of platelet indices in patients with deep neck space infection as a complication of acute tonsillitis. Tr-ENT. September 2017;27(4):179-184.
Chicago Binnetoğlu, Adem, Ali Cemal Yumuşakhuylu, Tekin Bağlam, Berat Demir, Fethullah Gerin, and Murat Sarı. “Evaluation of Platelet Indices in Patients With Deep Neck Space Infection As a Complication of Acute Tonsillitis”. The Turkish Journal of Ear Nose and Throat 27, no. 4 (September 2017): 179-84.
EndNote Binnetoğlu A, Yumuşakhuylu AC, Bağlam T, Demir B, Gerin F, Sarı M (September 1, 2017) Evaluation of platelet indices in patients with deep neck space infection as a complication of acute tonsillitis. The Turkish Journal of Ear Nose and Throat 27 4 179–184.
IEEE A. Binnetoğlu, A. C. Yumuşakhuylu, T. Bağlam, B. Demir, F. Gerin, and M. Sarı, “Evaluation of platelet indices in patients with deep neck space infection as a complication of acute tonsillitis”, Tr-ENT, vol. 27, no. 4, pp. 179–184, 2017.
ISNAD Binnetoğlu, Adem et al. “Evaluation of Platelet Indices in Patients With Deep Neck Space Infection As a Complication of Acute Tonsillitis”. The Turkish Journal of Ear Nose and Throat 27/4 (September 2017), 179-184.
JAMA Binnetoğlu A, Yumuşakhuylu AC, Bağlam T, Demir B, Gerin F, Sarı M. Evaluation of platelet indices in patients with deep neck space infection as a complication of acute tonsillitis. Tr-ENT. 2017;27:179–184.
MLA Binnetoğlu, Adem et al. “Evaluation of Platelet Indices in Patients With Deep Neck Space Infection As a Complication of Acute Tonsillitis”. The Turkish Journal of Ear Nose and Throat, vol. 27, no. 4, 2017, pp. 179-84.
Vancouver Binnetoğlu A, Yumuşakhuylu AC, Bağlam T, Demir B, Gerin F, Sarı M. Evaluation of platelet indices in patients with deep neck space infection as a complication of acute tonsillitis. Tr-ENT. 2017;27(4):179-84.