The effect of experimental hypothyroidism on nasal mucosa

Year 2018, Volume: 28 Issue: 1, 21 - 25, 05.03.2018

Yeşim Başal Ceren Günel Nuket Özkavruk Eliyatkın Gökhan Cesur Aylin Eryılmaz

Abstract

Objectives: This study aims to investigate the histopathological changes in nasal mucosa and alterations in thyroid hormone receptors in an experimental postnatal hypothyroidism model. Materials and Methods: Twenty-one Wistar albino newborn rats born from the pregnant rats were enrolled in this prospective randomized study and were divided into two groups: Group 1 n=11, methimazole, MMI -induced hypothyroidism group given MMIwater, and Group 2 n=10, control group , normal tap water. When the offspring reached 90 days, they were decapitated and the nasal mucosa was removed. Thyroid hormone receptor TR-a, TR-b status was assessed by immunohistochemical staining. Results: The difference between hypothyroidism and control groups regarding inflammation was statistically significant p<0.001 , as were the differences between hypothyroidism and control groups regarding edema and vascular proliferation p<0.001, p=0.001 . Staining was identified in sebaceous gland structures with immunohistochemical staining for thyroid hormone receptors. No statistically significant difference was found between the hypothyroidism and control groups regarding TR-a and TR-b. Conclusion: Thyroid hormone receptors are present in nasal mucosa. Edema, inflammation, and vascular proliferation occur in nasal mucosa due to hypothyroidism.

Keywords

hypothyroidism, rhinitis, thyroid hormone receptor, TR-a, TR-b

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