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Comparative immunohistochemical characteristics of benign and malignant major salivary gland tumors: A retrospective study

Year 2019, Volume: 29 Issue: 1, 9 - 20, 10.03.2019

Abstract

Objectives: This study aims to characterize the cellular components of major salivary gland tumors and to identify the differentiating markers between tumor subtypes. Patients and Methods: Between January 2006 and December 2010, a total of 83 patients 42 males, 41 females; mean age 50.2±15.8 years; range, 21 to 82 years with major salivary gland tumors n=12 mucoepidermoid carcinomas, n=8 adenoid cystic carcinomas, n=3 acinic cell carcinomas, n=4 salivary duct carcinomas, n=2 myoepitheliomas, n=5 basal cell adenomas, n=31 pleomorphic adenomas, and n=18 Warthin tumors with myoepithelial and epithelial immunohistochemical markers smooth muscle actin [SMA], calponin, S100, CD10, GFAP, p63, GCDFP15, GLUT1, 34ßE12, CK14, CK19, CD117, and galectin-3 were evaluated using tissue microarray method. Results: The GFAP, S100, CK14, p63, and CK5/6 expressions were significantly lower in the malignant tumors p<0.05 , whereas the expression of neither SMA, nor calponin was significantly different between benign and malignant tumors. The CK19 expression was significantly higher in malignant tumors p=0.004 . Diffuse CD117 expression favored an adenoid cystic carcinoma; GFAP expression favored a pleomorphic adenoma; 34ßE12, p63, and CK5/6 expression favored a mucoepidermoid carcinoma; and GCDFP15 favored a salivary duct carcinoma and acinic cell carcinoma. Conclusion: Our study results showed that distinct tumor types exhibited different preferences for various markers. We, therefore, suggest that immunohistochemical characteristics of myoepithelial cells, rather than the quantity per se, show a significant difference between malignant and benign salivary gland tumors and CK19 expression may indicate the malignant nature of a salivary gland tumor in difficult-to-diagnose tumors

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There are 47 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Saba Kiremitçi This is me

Serpil Dizbay Sak This is me

Publication Date March 10, 2019
Published in Issue Year 2019 Volume: 29 Issue: 1

Cite

APA Kiremitçi, S., & Dizbay Sak, S. (2019). Comparative immunohistochemical characteristics of benign and malignant major salivary gland tumors: A retrospective study. The Turkish Journal of Ear Nose and Throat, 29(1), 9-20.
AMA Kiremitçi S, Dizbay Sak S. Comparative immunohistochemical characteristics of benign and malignant major salivary gland tumors: A retrospective study. Tr-ENT. March 2019;29(1):9-20.
Chicago Kiremitçi, Saba, and Serpil Dizbay Sak. “Comparative Immunohistochemical Characteristics of Benign and Malignant Major Salivary Gland Tumors: A Retrospective Study”. The Turkish Journal of Ear Nose and Throat 29, no. 1 (March 2019): 9-20.
EndNote Kiremitçi S, Dizbay Sak S (March 1, 2019) Comparative immunohistochemical characteristics of benign and malignant major salivary gland tumors: A retrospective study. The Turkish Journal of Ear Nose and Throat 29 1 9–20.
IEEE S. Kiremitçi and S. Dizbay Sak, “Comparative immunohistochemical characteristics of benign and malignant major salivary gland tumors: A retrospective study”, Tr-ENT, vol. 29, no. 1, pp. 9–20, 2019.
ISNAD Kiremitçi, Saba - Dizbay Sak, Serpil. “Comparative Immunohistochemical Characteristics of Benign and Malignant Major Salivary Gland Tumors: A Retrospective Study”. The Turkish Journal of Ear Nose and Throat 29/1 (March 2019), 9-20.
JAMA Kiremitçi S, Dizbay Sak S. Comparative immunohistochemical characteristics of benign and malignant major salivary gland tumors: A retrospective study. Tr-ENT. 2019;29:9–20.
MLA Kiremitçi, Saba and Serpil Dizbay Sak. “Comparative Immunohistochemical Characteristics of Benign and Malignant Major Salivary Gland Tumors: A Retrospective Study”. The Turkish Journal of Ear Nose and Throat, vol. 29, no. 1, 2019, pp. 9-20.
Vancouver Kiremitçi S, Dizbay Sak S. Comparative immunohistochemical characteristics of benign and malignant major salivary gland tumors: A retrospective study. Tr-ENT. 2019;29(1):9-20.