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Pathogenesis and pathophysiology of Meniere’s disease: An update

Year 2019, Volume: 29 Issue: 4, 200 - 206, 10.12.2019

Abstract

Meniere’s disease is known with certain clinical symptoms such as fluctuating hearing loss, episodic vertigo, and tinnitus and characterized by endolymphatic hydrops found on post-mortem examination. The pathophysiology of Meniere’s disease is still questionable, and it has not been fully understood despite almost a century of research. Many determinants are effective in the occurrence of endolymphatic hydrops and in the pathogenesis of relevant cochleovestibular dysfunction. This review discusses research studies conducted in recent years concerning the pathogenesis and pathophysiology of Meniere’s disease. Histopathological research studies conducted in recent years on patients with Meniere’s disease have often focused on certain subjects as follows: aquaporins, oxidative stress, genetics, cochlear lateral wall changes, longitudinal flow blockage, intraskeletal channels of the otic capsule, hydropic and cellular changes in Reissner’s membrane, cochlear hair cells and spiral ganglion cells, round window thickness, basement membrane pathology, and otolithic membrane damages. Recent studies conducted on pathogenesis mechanisms of Meniere’s disease would provide an insight for the improvement of diagnosis and treatment of this weakening disease.

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There are 42 citations in total.

Details

Primary Language English
Journal Section Collection
Authors

Pelin Koçdor This is me

Micheal Paparella This is me

Meredith Adams This is me

Sebahattin Cüreoğlu This is me

Publication Date December 10, 2019
Published in Issue Year 2019 Volume: 29 Issue: 4

Cite

APA Koçdor, P., Paparella, M., Adams, M., Cüreoğlu, S. (2019). Pathogenesis and pathophysiology of Meniere’s disease: An update. The Turkish Journal of Ear Nose and Throat, 29(4), 200-206.
AMA Koçdor P, Paparella M, Adams M, Cüreoğlu S. Pathogenesis and pathophysiology of Meniere’s disease: An update. Tr-ENT. December 2019;29(4):200-206.
Chicago Koçdor, Pelin, Micheal Paparella, Meredith Adams, and Sebahattin Cüreoğlu. “Pathogenesis and Pathophysiology of Meniere’s Disease: An Update”. The Turkish Journal of Ear Nose and Throat 29, no. 4 (December 2019): 200-206.
EndNote Koçdor P, Paparella M, Adams M, Cüreoğlu S (December 1, 2019) Pathogenesis and pathophysiology of Meniere’s disease: An update. The Turkish Journal of Ear Nose and Throat 29 4 200–206.
IEEE P. Koçdor, M. Paparella, M. Adams, and S. Cüreoğlu, “Pathogenesis and pathophysiology of Meniere’s disease: An update”, Tr-ENT, vol. 29, no. 4, pp. 200–206, 2019.
ISNAD Koçdor, Pelin et al. “Pathogenesis and Pathophysiology of Meniere’s Disease: An Update”. The Turkish Journal of Ear Nose and Throat 29/4 (December 2019), 200-206.
JAMA Koçdor P, Paparella M, Adams M, Cüreoğlu S. Pathogenesis and pathophysiology of Meniere’s disease: An update. Tr-ENT. 2019;29:200–206.
MLA Koçdor, Pelin et al. “Pathogenesis and Pathophysiology of Meniere’s Disease: An Update”. The Turkish Journal of Ear Nose and Throat, vol. 29, no. 4, 2019, pp. 200-6.
Vancouver Koçdor P, Paparella M, Adams M, Cüreoğlu S. Pathogenesis and pathophysiology of Meniere’s disease: An update. Tr-ENT. 2019;29(4):200-6.