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The effects of hyperbaric oxygen therapy on an experimental cisplatin-induced ototoxicity model

Year 2020, Volume: 30 Issue: 2, 46 - 51, 09.07.2020

Abstract

Objectives: This study aims to investigate the protective effect of hyperbaric oxygen therapy HBOT as an antioxidant agent on cisplatin ototoxicity. Materials and Methods: Between June 4th, 2014 and June 13th, 2014, a total of 15 adult female Wistar albino rats were used in this study. The rats were divided into the following groups: Group A comprised of five rats and had prophylactic one course of HBOT before intraperitoneal IP cisplatin injection, followed by two more courses of HBOT. Group B comprised of five rats receiving three cycles of HBOT after 10 mg/kg of IP cisplatin administration. Group C served as the control group, including five rats, and received 10 mg/kg IP cisplatin without any additional treatment. The distortion product otoacoustic emission amplitudes of the rats were obtained before and after the study. Results: Group A and Group C showed a significant decrease in all measurements 4,004 Hz, 4,761 Hz, 5,188 Hz, 5,652 Hz, 6,726 Hz, and 7,996 Hz after cisplatin administration compared to that of baseline measurement. In Group B, a significant decrease was observed in the majority of the measurements, although no significant difference was found in 4,761 Hz. Conclusion: Our study results suggest that HBOT neither provides a protective nor therapeutic effect in a rat cisplatin-ototoxicity model.

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There are 22 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Burak Dikmen This is me

Hakan Avcı This is me

Şaban Çelebi This is me

Publication Date July 9, 2020
Published in Issue Year 2020 Volume: 30 Issue: 2

Cite

APA Dikmen, B., Avcı, H., & Çelebi, Ş. (2020). The effects of hyperbaric oxygen therapy on an experimental cisplatin-induced ototoxicity model. The Turkish Journal of Ear Nose and Throat, 30(2), 46-51.
AMA Dikmen B, Avcı H, Çelebi Ş. The effects of hyperbaric oxygen therapy on an experimental cisplatin-induced ototoxicity model. Tr-ENT. July 2020;30(2):46-51.
Chicago Dikmen, Burak, Hakan Avcı, and Şaban Çelebi. “The Effects of Hyperbaric Oxygen Therapy on an Experimental Cisplatin-Induced Ototoxicity Model”. The Turkish Journal of Ear Nose and Throat 30, no. 2 (July 2020): 46-51.
EndNote Dikmen B, Avcı H, Çelebi Ş (July 1, 2020) The effects of hyperbaric oxygen therapy on an experimental cisplatin-induced ototoxicity model. The Turkish Journal of Ear Nose and Throat 30 2 46–51.
IEEE B. Dikmen, H. Avcı, and Ş. Çelebi, “The effects of hyperbaric oxygen therapy on an experimental cisplatin-induced ototoxicity model”, Tr-ENT, vol. 30, no. 2, pp. 46–51, 2020.
ISNAD Dikmen, Burak et al. “The Effects of Hyperbaric Oxygen Therapy on an Experimental Cisplatin-Induced Ototoxicity Model”. The Turkish Journal of Ear Nose and Throat 30/2 (July 2020), 46-51.
JAMA Dikmen B, Avcı H, Çelebi Ş. The effects of hyperbaric oxygen therapy on an experimental cisplatin-induced ototoxicity model. Tr-ENT. 2020;30:46–51.
MLA Dikmen, Burak et al. “The Effects of Hyperbaric Oxygen Therapy on an Experimental Cisplatin-Induced Ototoxicity Model”. The Turkish Journal of Ear Nose and Throat, vol. 30, no. 2, 2020, pp. 46-51.
Vancouver Dikmen B, Avcı H, Çelebi Ş. The effects of hyperbaric oxygen therapy on an experimental cisplatin-induced ototoxicity model. Tr-ENT. 2020;30(2):46-51.