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Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructive sleep apnea?

Year 2020, Volume: 30 Issue: 2, 52 - 57, 09.07.2020

Üstün Osma Ömer Tarık Selçuk Mete Eyigör Levent Renda Nursel Türkoğlu Selçuk Hülya Eyigör Mustafa Deniz Yılmaz Oğuzhan İlden Ünal Gökalp Işık Hande Konsuk Ünlü Meral Gültekin

Abstract

Objectives: The aim of this study was to evaluate serum copeptin levels in patients with obstructive sleep apnea OSA before and after the positive airway pressure PAP treatment. Patients and Methods: A total of 16 patients 14 males, 2 females; median age 48 years; range, 38 to 60 years with severe sleep apnea based on the Apnea Hypopnea Index AHI >30 and 20 healthy controls 10 males, 10 females; median age 35.5 years; range, 22 to 47 years were included in this study between October 2014 and December 2015. Full-night polysomnography was applied to each patient. Serum copeptin levels were determined using the enzyme-linked immunosorbent assay in both groups. Serum copeptin level measurement was repeated in the patient group after one year of PAP treatment. Results: After one year of PAP treatment, serum copeptin levels of the patients with OSA decreased, although there was no statistically significant difference before and after treatment. Conclusion: Increased serum copeptin concentration may reflect a response to moderate stress in many diseases, particularly cardiovascular diseases. Based on our study results, there was no significant difference between the severe OSA group and healthy volunteers and before and after treatment among the patients with severe OSA.

Keywords

Copeptin severe obstructive sleep apnea sleep apnea vasopressin.

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There are 17 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Üstün Osma This is me

Ömer Tarık Selçuk This is me

Mete Eyigör This is me

Levent Renda This is me

Nursel Türkoğlu Selçuk This is me

Hülya Eyigör This is me

Mustafa Deniz Yılmaz This is me

Oğuzhan İlden This is me

Ünal Gökalp Işık This is me

Hande Konsuk Ünlü This is me

Meral Gültekin This is me

Publication Date July 9, 2020
Published in Issue Year 2020 Volume: 30 Issue: 2

Cite

APA Osma, Ü., Selçuk, Ö. T., Eyigör, M., Renda, L., et al. (2020). Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructive sleep apnea?. The Turkish Journal of Ear Nose and Throat, 30(2), 52-57.
AMA Osma Ü, Selçuk ÖT, Eyigör M, Renda L, Türkoğlu Selçuk N, Eyigör H, Yılmaz MD, İlden O, Işık ÜG, Konsuk Ünlü H, Gültekin M. Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructive sleep apnea?. Tr-ENT. July 2020;30(2):52-57.
Chicago Osma, Üstün, Ömer Tarık Selçuk, Mete Eyigör, Levent Renda, Nursel Türkoğlu Selçuk, Hülya Eyigör, Mustafa Deniz Yılmaz, Oğuzhan İlden, Ünal Gökalp Işık, Hande Konsuk Ünlü, and Meral Gültekin. “Do Serum Copeptin Levels Change With Positive Airway Pressure Treatment in Patients With Severe Obstructive Sleep Apnea?”. The Turkish Journal of Ear Nose and Throat 30, no. 2 (July 2020): 52-57.
EndNote Osma Ü, Selçuk ÖT, Eyigör M, Renda L, Türkoğlu Selçuk N, Eyigör H, Yılmaz MD, İlden O, Işık ÜG, Konsuk Ünlü H, Gültekin M (July 1, 2020) Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructive sleep apnea?. The Turkish Journal of Ear Nose and Throat 30 2 52–57.
IEEE Ü. Osma, “Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructive sleep apnea?”, Tr-ENT, vol. 30, no. 2, pp. 52–57, 2020.
ISNAD Osma, Üstün et al. “Do Serum Copeptin Levels Change With Positive Airway Pressure Treatment in Patients With Severe Obstructive Sleep Apnea?”. The Turkish Journal of Ear Nose and Throat 30/2 (July 2020), 52-57.
JAMA Osma Ü, Selçuk ÖT, Eyigör M, Renda L, Türkoğlu Selçuk N, Eyigör H, Yılmaz MD, İlden O, Işık ÜG, Konsuk Ünlü H, Gültekin M. Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructive sleep apnea?. Tr-ENT. 2020;30:52–57.
MLA Osma, Üstün et al. “Do Serum Copeptin Levels Change With Positive Airway Pressure Treatment in Patients With Severe Obstructive Sleep Apnea?”. The Turkish Journal of Ear Nose and Throat, vol. 30, no. 2, 2020, pp. 52-57.
Vancouver Osma Ü, Selçuk ÖT, Eyigör M, Renda L, Türkoğlu Selçuk N, Eyigör H, Yılmaz MD, İlden O, Işık ÜG, Konsuk Ünlü H, Gültekin M. Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructive sleep apnea?. Tr-ENT. 2020;30(2):52-7.