Research Article
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Year 2022, Volume: 32 Issue: 1, 13 - 17, 10.03.2022
https://doi.org/10.26650/Tr-ENT.2021.977456

Abstract

References

  • 1. Han BI, Lee HW, Kim TY, Lim SJ, Shin SK. Tinnitus: characteristics, causes, mechanisms, and treatments. J Clin Neurol 2009;5(1):11-9. google scholar
  • 2. Berkiten G, Yildirim G, Topaloglu I, Ugras H. Vitamin B12 levels in patients with tinnitus and effectiveness of vitamin B12 treatment on hearing threshold and tinnitus. B-ENT 2013;9(2):111-6. google scholar
  • 3. Yüksel F, Karataş D. Can Platelet Indices Be New Biomarkers for Subjective Tinnitus? J Craniofac Surg 2016;27(5):e420-4. doi: 10.1097/SCS.0000000000002693. google scholar
  • 4. Kazmierczak H, Doroszewska G. Metabolic disorders in vertigo, tinnitus, and hearing loss. Int Tinnitus J 2001;7(1):54-8. google scholar
  • 5. Celikbilek A, Gencer ZK, Saydam L, Zararsiz G, Tanik N, Ozkiris N. Serum uric acid levels correlate with benign paroxysmal positional vertigo. Eur J Neurol 2014;21(1):79-85. google scholar
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  • 10. Atik A. Pathophysiology and treatment of tinnitus: an elusive disease. Indian J Otolaryngol Head Neck Surg 2014;66(Suppl 1):1-5. google scholar
  • 11. Baguley D, McFerran D, Hall D. Tinnitus. Lancet 2013;382(9904):1600-7. google scholar
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  • 13. Henry JA, Dennis KC, Schechter MA. General review of tinnitus: prevalence, mechanisms, effects, and management. J Speech Lang Hear Res 2005;48(5):1204-35. google scholar
  • 14. Huang YS, Koo M, Chen JC, Hwang JH. The association between tinnitus and the risk of ischemic cerebrovascular disease in young and middle-aged patients: A secondary case-control analysis of a nationwide, population-based health claims database. PloS One 2017;12(11):e0187474. doi: 10.1371/journal.pone.0187474 google scholar
  • 15. Figueiredo RR, Azevedo AA, Penido NO. Positive Association between Tinnitus and Arterial Hypertension. Front Neurol 2016;7:171. google scholar
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  • 17. Gagliardi AC, Miname MH, Santos RD. Uric acid: A marker of increased cardiovascular risk. Atherosclerosis 2009;202(1):11-7. google scholar
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  • 21. Ilancioglu M, Ural A, Cobanoglu B, Orem A. Role of uric acid and other parameters in sudden sensorineural hearing loss. Exp Biomed Res 2020;3(2):99-109. google scholar
  • 22. Yang X, Yang B, Wu M, Wang F , Huang X, Li K et al. Association Between Serum Uric Acid Levels and Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis of Observational Studies. Front Neurol 2019;10:91. google scholar
  • 23. Parker G, Roy K, Wilhelm K, Mitchell P. Assessing the comparative effectiveness of antidepressant therapies: a prospective clinical practice study. J Clin Psychiatry 2001;62(2):117-25. google scholar
  • 24. Wegner I, Hall DA, Smit AL, McFerran D, Stegeman I. Betahistine for tinnitus. Cochrane Database Syst Rev 2018;12(12):Cd013093. google scholar
  • 25. McFerran DJ, Stockdale D, Holme R, Large CH, Baguley DM. Why Is There No Cure for Tinnitus? Front Neurosci 2019;13:802. google scholar
  • 26. Bayraktar C, Taşolar S. Relationship between increased carotid artery stiffness and idiopathic subjective tinnitus. Eur Arch Otorhinolaryngol 2017;274(5):2125-30. google scholar

Is Serum Uric Acid Level a Prognostic Value for Tinnitus Severity?

Year 2022, Volume: 32 Issue: 1, 13 - 17, 10.03.2022
https://doi.org/10.26650/Tr-ENT.2021.977456

Abstract

Objective: Tinnitus is a disease that concerns a large part of society and its pathophysiology and etiology have not been exactly clarified. This study will investigate the association between serum uric acid (SUA) levels and idiopathic subjective tinnitus.

Material and Methods: Ninety-one tinnitus patients and 45 age- and sex-matched healthy volunteers were included in the study. Patients were divided into two groups as mild tinnitus and severe tinnitus according to the Tinnitus Handicap Inventory questionnaire. They underwent otolaryngologic examination, routine hematological and biochemical analyses, pure tone audiometry, doppler ultrasound, and magnetic resonance imaging to exclude possible causes of tinnitus. Patients with abnormalities in any test result were excluded from the study. The blood test results were statistically compared between the groups.

Results: Except for SUA levels, no significant difference was found between groups in any blood test results (p>0.05). Significant differences among the groups were determined in SUA levels (p=0.001). SUA levels were found to be significantly higher in the severe tinnitus group than in the mild tinnitus or control group (p=0.002, p=0.001). However, there is no statistically significant difference between the mild tinnitus group and the control group (p=0.617).

Conclusion: In this study, it was observed that there was a clear correlation between higher SUA levels and severe tinnitus. But this association did not reveal SUA levels as an accurate biological marker for tinnitus. It could only be utilized as a marker of disease severity. Further studies will help to reveal the exact relation.

References

  • 1. Han BI, Lee HW, Kim TY, Lim SJ, Shin SK. Tinnitus: characteristics, causes, mechanisms, and treatments. J Clin Neurol 2009;5(1):11-9. google scholar
  • 2. Berkiten G, Yildirim G, Topaloglu I, Ugras H. Vitamin B12 levels in patients with tinnitus and effectiveness of vitamin B12 treatment on hearing threshold and tinnitus. B-ENT 2013;9(2):111-6. google scholar
  • 3. Yüksel F, Karataş D. Can Platelet Indices Be New Biomarkers for Subjective Tinnitus? J Craniofac Surg 2016;27(5):e420-4. doi: 10.1097/SCS.0000000000002693. google scholar
  • 4. Kazmierczak H, Doroszewska G. Metabolic disorders in vertigo, tinnitus, and hearing loss. Int Tinnitus J 2001;7(1):54-8. google scholar
  • 5. Celikbilek A, Gencer ZK, Saydam L, Zararsiz G, Tanik N, Ozkiris N. Serum uric acid levels correlate with benign paroxysmal positional vertigo. Eur J Neurol 2014;21(1):79-85. google scholar
  • 6. Fenech G, Rajzbaum G, Mazighi M, Blacher J. Serum uric acid and cardiovascular risk: state of the art and perspectives. Joint Bone Spine 2014;81(5):392-7. google scholar
  • 7. Bhole V, Choi JWJ, Woo Kim S, Vera M, Choi H. Serum Uric Acid Levels and the Risk of Type 2 Diabetes: A Prospective Study. Am J Med 2010;123(10):957-61. google scholar
  • 8. Verdecchia P, Schillaci G, Reboldi G, Santeusanio F, Porcellati C, Brunetti P. Relation between serum uric acid and risk of cardiovascular disease in essential hypertension: the PIUMA study. Hypertension 2000;36(6):1072-8. google scholar
  • 9. Aksoy S, Firat Y, Alpar R. The Tinnitus Handicap Inventory: a study of validity and reliability. Int Tinnitus J 2007;13(2):94-8. google scholar
  • 10. Atik A. Pathophysiology and treatment of tinnitus: an elusive disease. Indian J Otolaryngol Head Neck Surg 2014;66(Suppl 1):1-5. google scholar
  • 11. Baguley D, McFerran D, Hall D. Tinnitus. Lancet 2013;382(9904):1600-7. google scholar
  • 12. Martines F, Bentivegna D, Martines E, Sciacca V, Martinciglio G. Assessing audiological, pathophysiological and psychological variables in tinnitus patients with or without hearing loss. Eur Arch Otorhinolaryngol 2010;267(11):1685-93. google scholar
  • 13. Henry JA, Dennis KC, Schechter MA. General review of tinnitus: prevalence, mechanisms, effects, and management. J Speech Lang Hear Res 2005;48(5):1204-35. google scholar
  • 14. Huang YS, Koo M, Chen JC, Hwang JH. The association between tinnitus and the risk of ischemic cerebrovascular disease in young and middle-aged patients: A secondary case-control analysis of a nationwide, population-based health claims database. PloS One 2017;12(11):e0187474. doi: 10.1371/journal.pone.0187474 google scholar
  • 15. Figueiredo RR, Azevedo AA, Penido NO. Positive Association between Tinnitus and Arterial Hypertension. Front Neurol 2016;7:171. google scholar
  • 16. Wu AH, Gladden JD, Ahmed M, Ahmed A, Filippatos G. Relation of serum uric acid to cardiovascular disease. Int J Cardiol 2016;213:4-7. google scholar
  • 17. Gagliardi AC, Miname MH, Santos RD. Uric acid: A marker of increased cardiovascular risk. Atherosclerosis 2009;202(1):11-7. google scholar
  • 18. Ruggiero C, Cherubini A, Ble A, et al. Uric acid and inflammatory markers. Eur Heart J 2006;27(10):1174-81. google scholar
  • 19. Sakr HI, Khowailed AA, Al-Fakharany RS, Abdel-Fattah DS, Taha AA. Serum Uric Acid Level as a Predictive Biomarker of Gestational Hypertension Severity; A Prospective Observational Case-Control Study. Rev Recent Clin Trials 2020;15(3):227-39. google scholar
  • 20. Sui X, Church TS, Meriwether RA, Lobelo F, Blair SN. Uric acid and the development of metabolic syndrome in women and men. Metabolism 2008;57(6):845-52. google scholar
  • 21. Ilancioglu M, Ural A, Cobanoglu B, Orem A. Role of uric acid and other parameters in sudden sensorineural hearing loss. Exp Biomed Res 2020;3(2):99-109. google scholar
  • 22. Yang X, Yang B, Wu M, Wang F , Huang X, Li K et al. Association Between Serum Uric Acid Levels and Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis of Observational Studies. Front Neurol 2019;10:91. google scholar
  • 23. Parker G, Roy K, Wilhelm K, Mitchell P. Assessing the comparative effectiveness of antidepressant therapies: a prospective clinical practice study. J Clin Psychiatry 2001;62(2):117-25. google scholar
  • 24. Wegner I, Hall DA, Smit AL, McFerran D, Stegeman I. Betahistine for tinnitus. Cochrane Database Syst Rev 2018;12(12):Cd013093. google scholar
  • 25. McFerran DJ, Stockdale D, Holme R, Large CH, Baguley DM. Why Is There No Cure for Tinnitus? Front Neurosci 2019;13:802. google scholar
  • 26. Bayraktar C, Taşolar S. Relationship between increased carotid artery stiffness and idiopathic subjective tinnitus. Eur Arch Otorhinolaryngol 2017;274(5):2125-30. google scholar
There are 26 citations in total.

Details

Primary Language English
Subjects Otorhinolaryngology
Journal Section Research Article
Authors

Uğur Yıldırım 0000-0002-2373-6235

Publication Date March 10, 2022
Submission Date August 2, 2021
Published in Issue Year 2022 Volume: 32 Issue: 1

Cite

APA Yıldırım, U. (2022). Is Serum Uric Acid Level a Prognostic Value for Tinnitus Severity?. The Turkish Journal of Ear Nose and Throat, 32(1), 13-17. https://doi.org/10.26650/Tr-ENT.2021.977456
AMA Yıldırım U. Is Serum Uric Acid Level a Prognostic Value for Tinnitus Severity?. Tr-ENT. March 2022;32(1):13-17. doi:10.26650/Tr-ENT.2021.977456
Chicago Yıldırım, Uğur. “Is Serum Uric Acid Level a Prognostic Value for Tinnitus Severity?”. The Turkish Journal of Ear Nose and Throat 32, no. 1 (March 2022): 13-17. https://doi.org/10.26650/Tr-ENT.2021.977456.
EndNote Yıldırım U (March 1, 2022) Is Serum Uric Acid Level a Prognostic Value for Tinnitus Severity?. The Turkish Journal of Ear Nose and Throat 32 1 13–17.
IEEE U. Yıldırım, “Is Serum Uric Acid Level a Prognostic Value for Tinnitus Severity?”, Tr-ENT, vol. 32, no. 1, pp. 13–17, 2022, doi: 10.26650/Tr-ENT.2021.977456.
ISNAD Yıldırım, Uğur. “Is Serum Uric Acid Level a Prognostic Value for Tinnitus Severity?”. The Turkish Journal of Ear Nose and Throat 32/1 (March 2022), 13-17. https://doi.org/10.26650/Tr-ENT.2021.977456.
JAMA Yıldırım U. Is Serum Uric Acid Level a Prognostic Value for Tinnitus Severity?. Tr-ENT. 2022;32:13–17.
MLA Yıldırım, Uğur. “Is Serum Uric Acid Level a Prognostic Value for Tinnitus Severity?”. The Turkish Journal of Ear Nose and Throat, vol. 32, no. 1, 2022, pp. 13-17, doi:10.26650/Tr-ENT.2021.977456.
Vancouver Yıldırım U. Is Serum Uric Acid Level a Prognostic Value for Tinnitus Severity?. Tr-ENT. 2022;32(1):13-7.