Which Is the Best Inflammatory Index in Bell’s Palsy?

Year 2023, Volume: 33 Issue: 3, 76 - 80, 04.10.2023

Erkun Tuncer , Mehmet Erkan Kahraman , Fatih Yüksel , Sinan Kır

https://doi.org/10.26650/Tr-ENT.2023.1285124

Abstract

Objective: This study aims to analyze previously suggested hematological markers in addition to the systemic inflammation response index (SIRI) and the aggregate index of systemic inflammation (AISI) in patients with Bell’s palsy (BP) and to identify the most important hematologic inflammatory marker among them.

Material and Methods: The study consisted of 87 patients with BP who were between the ages of 18 and 65. Sixty-three healthy controls with similar age and sex distribution were assembled. A retrospective examination was done on the patient and control group files. House Brackmann grading system stage at the admission of patients with BP was recorded. Routine complete blood count values obtained from the patients at the time of admission and before the start of treatment were recorded. The systemic immune-inflammatory index (SII), the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), the monocyte-to-lymphocyte ratio (MLR), SIRI, and AISI were all generated from these values.

Results: There were 39 (44.8%) men, 48 (55.2%) women in the BP group, and 34 (54.0%) men and 29 (46.0%) women in the control group. The patient group had substantially increased neutrophil, white blood cell, NLR, PLR, SII, SIRI, and AISI levels (P values: 0.001, 0.001, 0.001, 0.033, 0.001, 0.001, and 0.001, respectively). NLR, PLR, SII, SIRI, and AISI values were lower in Receiver Operating Characteristics curves (ROC) analysis than neutrophil the areas under the curves (AUC) values.

Conclusion: Neutrophil count was found to be more valuable than other inflammatory indexes in the diagnosis of BP.

Keywords

Bell’s palsy, hematologic parameters, inflammatory indexes

References

• Baugh RF, Basura GJ, Ishii LE, Schwartz SR, Drumheller CM, Burkholder R, et al. Clinical practice guideline: Bell’s palsy. Otolaryngol Head Neck Surg. 2013;149(3 Suppl):S1-27. google scholar
• McCaul JA, Cascarini L, Godden D, Coombes D, Brennan PA, Kerawala CJ. Evidence based management of Bell’s palsy. Br J Oral Maxillofac Surg 2014;52(5):387-91. google scholar
• Xiang N, Havers F, Chen T, Song Y, Tu W, Li L, et al. Use of national pneumonia surveillance to describe influenza A(H7N9) virus epidemiology, China, 2004-2013. Emerg Infect Dis. 2013;19(11):1784-90. google scholar
• Güneş M, Büyükgöl H. Relationship between generalized epileptic seizure and neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and neutrophil mediated inflammation. Int J Neurosci 2020;130(11):1095-100. google scholar
• Hong X, Cui B, Wang M, Yang Z, Wang L, Xu Q. Systemic Immuneinflammation Index, Based on Platelet Counts and Neutrophil- Lymphocyte Ratio, Is Useful for Predicting Prognosis in Small Cell Lung Cancer. Tohoku J Exp Med 2015;236(4):297-304. google scholar
• Nathan C. Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol. 2006;6(3):173-82. google scholar
• Oya R, Takenaka Y, Imai T, Sato T, Oshima K, Ohta Y, et al. Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Prognostic Hematologic Markers of Bell’s Palsy: A Meta-analysis. Otol Neurotol 2019;40(5):681-7. google scholar
• Kınar A, Ulu Ş, Bucak A, Kazan E. Can Systemic Immune- Inflammation Index (SII) be a prognostic factor of Bell’s palsy patients? Neurol Sci. 2021;42(8):3197-201. google scholar
• Takenaka Y, Oya R, Kitamiura T, Ashida N, Shimizu K, Takemura K, et al. Prognostic role of neutrophil-to-lymphocyte ratio in head and neck cancer: A meta-analysis. Head Neck. 2018;40(3):647-55. google scholar
• Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol. 2008;102(6):653-7. google scholar
• Walsh SR, Cook EJ, Goulder F, Justin TA, Keeling NJ. Neutrophillymphocyte ratio as a prognostic factor in colorectal cancer. J Surg Oncol. 2005;91(3):181-4. google scholar
• Cao Z, Li Z, Xiang H, Huang S, Gao J, Zhan X, et al. Prognostic role of haematological indices in sudden sensorineural hearing loss: Review and meta-analysis. Clin Chim Acta 2018;483:104-11. google scholar
• Kang JW, Kim MG, Kim SS, Im HI, Dong SH, Kim SH, et al. Neutrophil-lymphocyte ratio as a valuable prognostic marker in idiopathic sudden sensorineural hearing loss. Acta Otolaryngol 2020;140(4):307-13. google scholar
• Atan D, İkincioğulları A, Köseoğlu S, Özcan KM, Çetin MA, Ensari S, et al. New Predictive Parameters of Bell’s Palsy: Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio. Balkan Med J 2015;32(2):167-70. google scholar
• Bucak A, Ulu S, Oruc S, Yucedag F, Tekin MS, Karakaya F, et al. Neutrophil-to-lymphocyte ratio as a novel-potential marker for predicting prognosis of Bell palsy. Laryngoscope 2014;124(7):1678- 81. google scholar
• Kiliçkaya MM, Tuz M, Yariktaş M, Yasan H, Aynalı G, Bagci Ö. The Importance of the Neutrophil-Lymphocyte Ratio in Patients with Idiopathic Peripheral Facial Palsy. Int J Otolaryngol 2015;2015:981950. google scholar
• Özler GS, Günak G. Neutrophil-lymphocyte ratio: a new predictive and prognostic factor in patients with Bell palsy. J Craniofac Surg 2014;25(3):944-5. google scholar
• Ji Y, Wang H. Prognostic prediction of systemic immuneinflammation index for patients with gynecological and breast cancers: a meta-analysis. World J Surg Oncol 2020;18(1):197. google scholar
• Zhong JH, Huang DH, Chen ZY. Prognostic role of systemic immuneinflammation index in solid tumors: a systematic review and metaanalysis. Oncotarget 2017;8(43):75381-8. google scholar
• Chen L, Kong X, Wang Z, Wang X, Fang Y, Wang J. Pretreatment Systemic Inflammation Response Index in Patients with Breast Cancer Treated with Neoadjuvant Chemotherapy as a Useful Prognostic Indicator. Cancer Manag Res 2020;12:1543-67. google scholar
• Feng Y, Zhang N, Wang S, Zou W, He Y, Ma JA, et al. Systemic Inflammation Response Index Is a Predictor of Poor Survival in Locally Advanced Nasopharyngeal Carcinoma: A Propensity Score Matching Study. Front Oncol 2020;10:575417. google scholar
• Wei L, Xie H, Yan P. Prognostic value of the systemic inflammation response index in human malignancy: A meta-analysis. Medicine (Baltimore) 2020;99(50):e23486. google scholar
• Zinellu A, Collu C, Nasser M, Paliogiannis P, Mellino S, Zinellu E, et al. The Aggregate Index of Systemic Inflammation (AISI): A Novel Prognostic Biomarker in Idiopathic Pulmonary Fibrosis. J Clin Med 2021;10(18):4134. google scholar
• Erre GL, Buscetta G, Mangoni AA, Castagna F, Paliogiannis P, Oggiano M, et al. Diagnostic accuracy of different blood cellsderived indexes in rheumatoid arthritis: A cross-sectional study. Medicine (Baltimore) 2020;99(44):e22557. google scholar