Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma

Year 2024, Volume: 34 Issue: 1, 1 - 7, 27.03.2024

Saber Chebouki , Zeynep Nil Ünal , Kemal Koray Bal , Harun Gür , Onur İsmi , Murat Ünal

https://doi.org/10.26650/Tr-ENT.2024.1402917

Abstract

Objective: The paradoxical relationship between cancer and vitamin D has been known since 1990. Vitamin D receptor (VDR) is found in several tissues and, in contrast to popular belief, it is not only responsible for calcium and phosphorus metabolism but also associated with several other metabolic events. We conducted this study to investigate the effects of these factors on head and neck cancers by examining vitamin D, calcium, and phosphorus levels and polymorphisms of the VDR genes FokI and Bsm in patients with head and neck cancer.
Material and Methods: A total of 51 patients with head and neck squamous cell carcinoma aged 31-88 years and 51 healthy individuals aged 33-89 years who applied to the otorhinolaryngology outpatient clinic of Mersin University Faculty of Medicine were included in this study.
Results: No difference was observed in the distribution of the genotype ratios of the VDR genes FokI and Bsm between the two groups. However, a statistically significant difference was found in calcium levels between the two groups.
Conclusion: An individual with known VDR gene polymorphisms can provide possible risk information regarding which disease risk group he/she is in, and VDR gene polymorphism can be used as a biomarker.

Keywords

Vitamin D, genes, neoplasms, calcium, phosphorus, real-time polymerase chain reaction

Ethical Statement

The study was carried out in accordance with the principles of the Helsinki Declaration, and it started after the approval of Mersin University Clinical Research Ethics Committee, dated 12.02.2015 and decision number 2015/38, was obtained

Supporting Institution

This project was supported by Mersin University Scientific Research Projects Unit as project number 2015-TP2-1309

Project Number

2015-TP2-1309

Thanks

This project was supported by Mersin University Scientific Research Projects Unit as project number 2015-TP2-1309

References

• 1. Matsushita K, Sasagawa T, Miyashita M, Ishizaki A, Morishita A, Hosaka N, et al. Oral and cervical human papillomavirus infection among female sex workers in Japan. Jpn J Infect Dis 2011;64(1):34-9. google scholar
• 2. Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, et al. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev 2012;33(3):456-92. google scholar
• 3. Tanakol R. D Vitamin. In: Sencer E, editor . Endokrinoloji, Metabolizma ve Beslenme Hastalıkları Geriatri ilavesi ile. İstanbul: Nobel Tıp Kitapevi; 2001. pp 569-582. google scholar
• 4. Baker AR, McDonnell DP, Hughes M, Crisp TM, Mangelsdorf DJ, Haussler MR, et al. Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proc Natl Acad Sci U S A 1988;85(10):3294-8. google scholar
• 5. Tangpricha V. Vitamin D Deficiency and Related Disorders: Practice Essentials, Background, Pathophysiology. Medscape. 2016. November 8, 2016. https://emedicine.medscape.com/ article/128762-overview?form=fpf google scholar
• 6. Karki R, Pandya D, Elston RC, Ferlini C. Defining “mutation” and “polymorphism” in the era of personal genomics. BMC Med Genomics 2015;8:37. google scholar
• 7. Lee JH, O’Keefe JH, Bell D, Hensrud DD,Holick MF. Vitamin D deficiency an important,common, and easily treatable cardiovascular risk factor? J Am Coll Cardiol 2008;52(24):1949-56. google scholar
• 8. Shaikh F, Baig S, Jamal Q. Do VDR gene polymorphisms contribute to breast cancer? Asian Pac J Cancer Prev 2016;17(2):479-83. google scholar
• 9. Ekmekçi A, Konaç E, Önen Hİ. Gen polimorfizmi ve kansere yatkınlık. Marmara Medical Journal 2008;21:282-95. google scholar
• 10. Slattery ML. Defining dietary consumption: is the sum greater than its parts? Am J Clin Nutr 2008;88(1):14-5. google scholar
• 11. Liu JH, Li HW, Wang JQ, Li M, Xin DQ, Na X, et al. Vitamin D receptor gene Bsm I polymorphism and the susceptibility to prostate cancer in northern Chinese Han population. Zhonghua Nan Ke Xue 2003;9(6):413-6. google scholar
• 12. Slattery ML, Schumacher MC, Smith KR, West DW, Abd-Elghany N. Physical activity, diet, and risk of colon cancer in Utah. Am J Epidemiol 1988;128(5):989-99. google scholar
• 13. Kawase T, Matsuo K, Suzuki T, Hirose K, Hosono S, Watanabe M, et al. Association between vitamin D and calcium intake and breast cancer risk according to menopausal status and receptor status in Japan. Cancer Sci 2010;101(5):1234-40. google scholar
• 14. Grant WB, Garland CF. The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates. Anticancer Res 2006;26(4A):2687-99. google scholar
• 15. Zhang X, Giovannucci E. Calcium, vitamin D and colorectal cancer chemoprevention. Best Pract Res Clin Gastroenterol 2011;25(4-5):485-94. google scholar
• 16. Kornfehl J, Formanek M, Temmel A, Knerer B, Willheim M. Antiproliferative effects of the biologically active metabolite of vitamin D3 (1,25[OH]2D3) on head and neck squamous cell carcinoma cell lines. Eur Arch Otorhinolaryngol 1996;253(6):341-4. google scholar
• 17. Gandini S, Boniol M, Haukka J, Byrnes G, Cox B, Sneyd MJ, et al. Meta-analysis of observational studies of serum 25-hydroxyvitamin D levels and colorectal, breast and prostate cancer and colorectal adenoma. Int J Cancer 2011;128(6):1414-24. google scholar
• 18. Kim Y, Je Y. Vitamin D intake, blood 25(OH)D levels, and breast cancer risk or mortality: A meta-analysis. Br J Cancer 2014;110(11):2772-84. google scholar
• 19. Duffy MJ, Murray A, Synnott NC, O’Donovan N, Crown J. Vitamin D analogues: Potential use in cancer treatment. Crit Rev Oncol Hematol 2017;112:190-7. google scholar
• 20. Gandini S, Gnagnarella P, Serrano D, Pasquali E, Raimondi S. Vitamin D receptor polymorphisms and cancer. Adv Exp Med Biol 2014;810:69-105. google scholar
• 21. Liu Z, Calderon JI, Zhang Z, Sturgis EM, Spitz MR, Wei Q. Polymorphisms of vitamin D receptor gene protect against the risk of head and neck cancer. Pharmacogenet Genomics 2005;15(3):159-65. google scholar
• 22. Fanidi A, Muller DC, Midttun 0, Ueland PM, Vollset SE, Relton C, et al. Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort. Sci Rep 2016;6:36017. google scholar
• 23. Bobko AA, Eubank TD, Driesschaert B, Dhimitruka I, Evans J, Mohammad R, et al. Interstitial Inorganic Phosphate as a Tumor Microenvironment Marker for Tumor Progression. Sci Rep 2017;7:41233. google scholar
• 24. de Carvalho CCCR, Caramujo MJ. Tumor metastasis as an adaptation of tumor cells to fulfill their phosphorus requirements. Med Hypotheses 2012;78:664-7. google scholar
• 25. Tucci M, Mosca A, Lamanna G, Porpiglia F, Terzolo M, Vana F, et al. Prognostic significance of disordered calcium metabolism in hormone-refractory prostate cancer patients with metastatic bone disease. Prostate Cancer Prostatic Dis 2009;12(1):94-9. google scholar