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Immunomodulatory Potential of a Marine Sponge Spongosorites halichondrioides (Dendy, 1905)

Year 2012, Volume: 12 Issue: 1, 67 - 71, 01.02.2012

Abstract

Marine sponges are animals belonging to the Phylum Porifera. They are well known for its medicinal value. However, to prove its efficiency for the clinical utilization, more experimental data will be beneficial. The present study involved the investigation of immunomodulatory activities of methanolic extract of marine sponge Spongosorites halichondriodes from western coast of India. The extract was studied for acute toxicity (OECD-425 guideline), Haemagglutinating antibody (HA) titre, delayed-type hypersensitivity (DTH) response and cyclophosphamide-induced myelosuppression for their immunomodulatory potential. The evaluation of immunomodulatory potential by oral administration of methanolic extract of marine sponge (200 mg/kg) evoked a significant decrease in total WBC count as compared to control, in antibody titre values, and also in delayed type hypersensitivity reaction induced by sheep red blood cells. Also it prevented myelosuppression in cyclophosphamide drug treated rats. The results obtained in the present study indicated that extract of marine sponge Spongosorites halichondrioides possesses immunosuppressant activity and can be studied further for isolation of the compounds which can be used for organ rejection purpose in future.

Year 2012, Volume: 12 Issue: 1, 67 - 71, 01.02.2012

Abstract

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Details

Primary Language Turkish
Journal Section Articles
Authors

Maushmi S. Kumar This is me

Dipa Desai This is me

A.k. Pal This is me

Publication Date February 1, 2012
Published in Issue Year 2012 Volume: 12 Issue: 1

Cite

APA Kumar, M. S., Desai, D., & Pal, A. (2012). Immunomodulatory Potential of a Marine Sponge Spongosorites halichondrioides (Dendy, 1905). Turkish Journal of Fisheries and Aquatic Sciences, 12(1), 67-71.
AMA Kumar MS, Desai D, Pal A. Immunomodulatory Potential of a Marine Sponge Spongosorites halichondrioides (Dendy, 1905). Turkish Journal of Fisheries and Aquatic Sciences. February 2012;12(1):67-71.
Chicago Kumar, Maushmi S., Dipa Desai, and A.k. Pal. “Immunomodulatory Potential of a Marine Sponge Spongosorites Halichondrioides (Dendy, 1905)”. Turkish Journal of Fisheries and Aquatic Sciences 12, no. 1 (February 2012): 67-71.
EndNote Kumar MS, Desai D, Pal A (February 1, 2012) Immunomodulatory Potential of a Marine Sponge Spongosorites halichondrioides (Dendy, 1905). Turkish Journal of Fisheries and Aquatic Sciences 12 1 67–71.
IEEE M. S. Kumar, D. Desai, and A. Pal, “Immunomodulatory Potential of a Marine Sponge Spongosorites halichondrioides (Dendy, 1905)”, Turkish Journal of Fisheries and Aquatic Sciences, vol. 12, no. 1, pp. 67–71, 2012.
ISNAD Kumar, Maushmi S. et al. “Immunomodulatory Potential of a Marine Sponge Spongosorites Halichondrioides (Dendy, 1905)”. Turkish Journal of Fisheries and Aquatic Sciences 12/1 (February 2012), 67-71.
JAMA Kumar MS, Desai D, Pal A. Immunomodulatory Potential of a Marine Sponge Spongosorites halichondrioides (Dendy, 1905). Turkish Journal of Fisheries and Aquatic Sciences. 2012;12:67–71.
MLA Kumar, Maushmi S. et al. “Immunomodulatory Potential of a Marine Sponge Spongosorites Halichondrioides (Dendy, 1905)”. Turkish Journal of Fisheries and Aquatic Sciences, vol. 12, no. 1, 2012, pp. 67-71.
Vancouver Kumar MS, Desai D, Pal A. Immunomodulatory Potential of a Marine Sponge Spongosorites halichondrioides (Dendy, 1905). Turkish Journal of Fisheries and Aquatic Sciences. 2012;12(1):67-71.