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α-AMYLASE, α-GLUCOSIDASE AND LIPASE INHIBITORY PROPERTIES AND PHYTOCHEMICAL ANALYSIS OF ENDEMIC PLANT Jurinea brevicaulis Boiss.

Year 2023, , 41 - 49, 15.04.2023

Sıla Sener , Şeyda Kanbolat , Nevin Ulaş Çolak , Merve Badem , Rezzan Aliyazıcıoğlu , Ufuk Özgen , Ali Kandemir

https://doi.org/10.23902/trkjnat.1211654

Abstract

Obesity, defined as New World Syndrome, causes global health problems and big economic losses. Natural products have gained increasing importance because of their antiobesity potency. The genus Jurinea Cass. with approximately 200 described species worldwide has been traditionally used as a therapeutic agent for colic, fever, gout and rheumatism. The aim of this study was to analyze the volatile components, to determine phenolic compounds and to evaluate α-amylase, α-glucosidase, and lipase inhibitory activities of the endemic plant species Jurinea brevicaulis Boiss. The widely used solid-phase microextraction technique (SPME) was employed for Gas Chromatography-Mass Spectrometry (GC/MS) analysis of the volatile components. Quantitative analysis of phenolic compounds was performed using Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC). A total of 19 volatile components were specified and o-cymene (10.60 %), β-bisabolene (9.30 %), and sesquicineole (57.5 %) for different terpenes were described as major components. According to the RP-HPLC analysis, sinapic acid, p-coumaric acid and quercetin were determined for the species. IC50 values of the species were determined as 36.59 ± 2.37 μg/mL and 42.56 ± 2.83 μg/mL for α-amylase and α-glucosidase assays, respectively. IC50 value was found as 50.31 ± 3.75 μg/mL with the lipase inhibition analysis. In conclusion, it has been determined that J. brevicaulis included diverse volatile components, three phenolic compounds with antiobesity effect potential, which highlights J. brevicaulis as the up-and-coming candidate of natural product source to be used against obesity.

Keywords

RP-HPLC Lipase Jurinea Antiobesity SPME GC/MS

References

  • 1. Abudayyak, M., Kanbolat, Ş., Batur, Ş., Ergene, R.S. & Aliyazıcıoğlu, R. 2020. The biological activity; cytotoxicity and antioxidant activity of Jurinea brevicaulis. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 1(1): 1-14.
  • 2. Alam, M.A., Subhan, N., Hossain, H., Hossain, M., Reza, H.M., Rahman, M.M. & Ullah, M. 2016. Hydroxycinnamic acid derivatives: a potential class of natural compounds for the management of lipid metabolism and obesity. Nutrition & Metabolism, 13(1): 1-13.
  • 3. Alaofi, A.L. 2020. Sinapic acid ameliorates the progression of streptozotocin (stz)-induced diabetic nephropathy in rats via NRF2/HO-1 mediated pathways. Frontiers in Pharmacology, 11: 1-11.
  • 4. Bhardwaj, M., Yadav, P., Vashishth, D., Sharma, K., Kumar, A., Chahal, J., Dalal, S. & Kataria, S.K. 2021. A review on obesity management through natural compounds and a green nanomedicine-based approach. Molecules, 26(11): 3278.
  • 5. Bahadori, M.B., Zengin, G., Bahadori, S., Maggi, F. & Dinparast, L. 2017. Chemical composition of essential oil, antioxidant, antidiabetic, antiobesity, and neuroprotective properties of Prangos gaubae. Natural Product Communications, 12(12): 1945-1948.
  • 6. Bicchi, C., Liberto, E., Matteodo, M., Sgorbini, B., Mondello, L., Zellner, B.D.A., Costa, R. & Rubiolo, P. 2008. Quantitative analysis of essential oils: a complex task. Flavour and Fragrance Journal, 23: 382-391.
  • 7. Blüher, M. 2019. Obesity: global epidemiology and pathogenesis. Nature Reviews Endocrinology, 15: 288-298.
  • 8. Bustanji, Y., Al-Masri, I.M., Mohammad, M., Hudaib, M., Tawaha, K., Tarazi, H. & Alkhatib, H.S. 2011. Pancreatic lipase inhibition activity of trilactone terpenes of Ginkgo biloba. Journal of Enzyme Inhibition and Medicinal Chemistry, 26: 453-459.
  • 9. Calixto, J.B. 2019. The role of natural products in modern drug discovery. Anais da Academia Brasileira de Ciências, 91: 1-7.
  • 10. Dirar, A.I., Alsaadi, D.H.M., Wada, M., Mohamed, M.A., Watanabe, T. & Devkota, H.P. 2019. Effects of extraction solvents on total phenolic and flavonoid contents and biological activities of extracts from Sudanese medicinal plants. South African Journal of Botany, 120: 261-267.
  • 11. Dosoky, N.S. & Setzer, W.N. 2018. Chemical composition and biological activities of essential oils of Curcuma species. Nutrients, 10: 1-42.
  • 12. Dumaa, M., Gruner, M., Tilo, L., Solongo, T., Chunsriimyatav, G. & Knolker, H.J. 2018. Phytochemical study of Jurinea mongolica Maxim. Bulletin of the Institute of Chemistry and Chemical Technology, 6: 53-58.
  • 13. Endalifer, M.L. & Diress, G. 2020. Epidemiology, predisposing factors, biomarkers, and prevention mechanism of obesity. Journal of Obesity, 2020: 1-8.
  • 14. George, G., Sridhar, S.N.C. & Paul, A.T. 2020. Investigation of synergistic potential of green tea polyphenols and orlistat combinations using pancreatic lipase assay-based synergy directed fractionation strategy. South African Journal of Botany, 135: 50-57.
  • 15. Ghouse, M.S., Barwal, S.B. & Wattamwar, A.S. 2016. A Review on obesity. Health Science Journals, 10(4): 1-5.
  • 16. Han, X., Guo, J., You, Y., Zhan, J. & Hang, W. 2020. p-Coumaric acid prevents obesity via activating thermogenesis in brown adipose tissue mediated by mTORC1-RPS6. FASEB Journal, 34: 7810-7824.
  • 17. Jack, B.U., Malherbe, C.J., Huisamen, B., Gabuza, K., Mazibuko-Mbeje, S., Schulze, A.E., Joubert, E., Muller, C.J.F., Louw, J. & Pheiffer, C. 2017. A polyphenol-enriched fraction of Cyclopia intermedia decreases lipid content in 3T3-L1 adipocytes and reduces body weight gain of obese db/db mice. South African Journal of Botany, 110: 216-229.
  • 18. Jawed, A., Singh, G., Kohli, S., Sumera, A., Haque, S., Prasad, R. & Paul, D. 2019. Therapeutic role of lipases and lipase inhibitors derived from natural resources for remedies against metabolic disorders and lifestyle diseases. South African Journal of Botany, 120: 25-32.
  • 19. Jeong, E.Y., Cho, K.S. & Lee, H.S. 2012. α-amylase and α-glucosidase inhibitors isolated from Triticum aestivum L. sprouts. Journal of the Korean Society for Applied Biological Chemistry, 55: 47-51.
  • 20. Kanbolat, S., Korkmaz, N., Sener, S.O., Badem, M., Colak, N.U., Abudayyak, M., Aliyazicioglu, R., Ozgen, U., Kandemir, A. & Karaoglu, S.A. 2018. Antioxidant, antimicrobial, cytotoxic, anticholinesterase, antityrosinase activities and characterisation of volatile compounds of Verbascum oocarpum by SPME and GC-FID/MS. Journal of Pharmaceutical Research International, 24: 1-12.
  • 21. Karamać, M. & Amarowicz, R. 1996. Inhibition of pancreatic lipase by phenolic acids - examination in vitro. Zeitschrift für Naturforschung - Section C Journal of Biosciences, 51: 903-906.
  • 22. Korkmaz, N., Sener, S.O., Akkaya, S., Badem, M., Aliyazicioglu, R., Abudayyak, M., Oztas, E. & Ozgen, U. 2019. Investigation of antioxidant, cytotoxic, tyrosinase inhibitory activities, and phenolic profiles of green, white, and black teas. Turkish Journal of Biochemistry, 44(3): 278-288.
  • 23. Kumar, A. & Agnihotri, V.K. 2020. Phytochemical studies of Jurinea macrocephala roots from Western Himalaya. Natural Product Research, 34: 421-424. https://doi.org/10.1080/14786419.2018.1530233
  • 24. Liu, T.T., Liu, X.T., Chen, Q.X. & Shi, Y. 2020. Lipase inhibitors for obesity: a review. Biomedicine & Pharmacotherapy, 128: 1-9.
  • 25. Mahmood, N. 2016. A review of α-amylase inhibitors on weight loss and glycemic control in pathological state such as obesity and diabetes. Comparative Clinical Pathology, 25: 1253-1264.
  • 26. Marrelli, M., Loizzo, M.R., Nicoletti, M., Menichini, F. & Conforti, F. 2013. Inhibition of key enzymes linked to obesity by preparations from mediterranean dietary plants: effects on α-amylase and pancreatic lipase activities. Plant Foods for Human Nutrition, 68: 340-346.
  • 27. Mohamed, G.A., Ibrahim, S.R., Elkhayat, E.S. & El Dine, R.S. 2014. Natural anti-obesity agents. Bulletin of Faculty of Pharmacy, 52: 269-284.
  • 28. Palanisamy, U.D., Ling, L.T., Manaharan, T. & Appleton, D. 2011. Rapid isolation of geraniin from Nephelium lappaceum rind waste and its anti-hyperglycemic activity. Food Chemistry, 127: 21-27.
  • 29. Park, J.Y., Kim, C.S., Park, K.M. & Chang, P.S. 2019. Inhibitory characteristics of flavonol-3-O-glycosides from Polygonum aviculare L. (Common knotgrass) against porcine pancreatic lipase. Scientific Reports, 9: 1-10.
  • 30. Ragab, S.M.M., Abd Elghaffar, S.K., El-Metwally, T.H., Badr, G., Mahmoud, M.H. & Omar, H.M. 2015. Effect of a high fat, high sucrose diet on the promotion of non-alcoholic fatty liver disease in male rats: The ameliorative role of three natural compounds. Lipids in Health and Disease, 14: 1-11.
  • 31. Rashed, A.A., Mohd Nawi, M.N. & Sulaiman, K. 2017. Assessment of essential oil as a potential anti-obesity agent: a narrative review. Journal of Essential Oil Research, 29: 1-10.
  • 32. Rustaiyan, A. & Taherkhnai, M. 2013. Composition of the essential oil of Jurinea leptoloba growing wild in Iran. Journal of the British Association for the Study of Religions, 3: 708-710.
  • 33. Sergent, T., Vanderstraeten, J., Winand, J., Beguin, P. & Schneider, Y.J. 2012. Phenolic compounds and plant extracts as potential natural anti-obesity substances. Food Chemistry, 135: 68-73.
  • 34. Shah, N.A., Khan, M.R., Naz, K. & Khan, M.A. 2014. Antioxidant potential, DNA protection, and HPLC-DAD analysis of neglected medicinal Jurinea dolomiaea roots. BioMed Research International, 2014: 1-10.
  • 35. Singh, G., Suresh, S., Bayineni, V.K. & Kadeppagari, R.K. 2015. Lipase inhibitors from plants and their medical applications. International Journal of Pharmacy and Pharmaceutical Sciences, 7(1): 1-5.
  • 36. Singh, P., Singh, R., Sati, N., Sati, O.P. & Kumar, N. 2016. A review of genus: Jurinea. International Journal of Life-Sciences Scientific Research, 2: 23-30.
  • 37. Sukhev, S. & Singh, K.S. 2013. Therapeutic role of phytomedicines on obesity: importance of herbal pancreatic lipase inhibitors. International Research Journal of Medicine and Medical Sciences, 1: 15-26.
  • 38. Susanna, A., Garcia-Jacas, N., Hidalgo, O., Vilatersana, R. & Garnatje, T. 2006. The cardueae (Compositae) revisited: insights from ITS, trnL-trnF, and matK nuclear and chloroplast DNA analysis. Annals of the Missouri Botanical Garden, 93: 150-171.
  • 39. Tadera, K., Minami, Y., Takamatsu, K. & Matsuoka, T. 2006. Inhibition of α-glucosidase and α-amylase by flavonoids. Journal of Nutritional Science and Vitaminology, 52: 149-153.
  • 40. Trendafilova, A., Todorova, M., Kutova, N., & Guncheva, M. 2018. Phytochemical profile and anti-lipase activity of balkan endemic Jurinea tzar-ferdinandii. Natural Product Communications, 13(8): 1934578X1801300823.
  • 41. Tucci, S. 2010. The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 3: 125-143.
  • 42. Xiong, Y., Ng, K., Zhang, P., Warner, R.D., Shen, S., Tang, H.Y., Liang, Z. & Fang, Z. 2020. In vitro α-glucosidase and α-amylase inhibitory activities of free and bound phenolic extracts from the bran and kernel fractions of five sorghum grain genotypes. Foods, 9: 1301-1318.
  • 43. Yang, X.W., Huang, M.Z., Jin, Y.S., Sun, L.N., Song, Y. & Chen, H.S. 2012. Phenolics from Bidens bipinnata and their amylase inhibitory properties. Fitoterapia, 83: 1169-1175.
  • 44. Yen, G.C., Cheng, H.L., Lin, L.Y., Chen, S.C. & Hsu, C.L. 2020. The potential role of phenolic compounds on modulating gut microbiota in obesity. Journal of Food and Drug Analysis, 28: 1-11.
  • 45. Zhang, B.W., Xing, Y., Wen, C., Yu, X.X., Sun, W.L., Xiu, Z.L. & Dong, Y.S. 2017. Pentacyclic triterpenes as α-glucosidase and α-amylase inhibitors: Structure-activity relationships and the synergism with acarbose. Bioorganic & Medicinal Chemistry letters, 27(22): 5065-5070.
  • 46. Zhao, X., Chen, Q., Lu, T., Wei, F., Yang, Y., Xie, D., Wang, H. & Tian, M. 2020. Chemical composition, antibacterial, anti-inflammatory, and enzyme inhibitory activities of essential oil from Rhynchanthus beesianus rhizome. Molecules, 26: 167-179.

Year 2023, , 41 - 49, 15.04.2023

Sıla Sener , Şeyda Kanbolat , Nevin Ulaş Çolak , Merve Badem , Rezzan Aliyazıcıoğlu , Ufuk Özgen , Ali Kandemir

https://doi.org/10.23902/trkjnat.1211654

Abstract

Yeni dünya sendromu olarak tanımlanan obezite, küresel sağlık sorunlarına ve büyük ekonomik kayıplara neden olmaktadır. Antiobezite potansiyelleri nedeniyle doğal ürünler, giderek artan bir önem kazanmaktadır. Jurinea Cass. cinsi dünya çapında yaklaşık 200 tür içermektedir ve geleneksel olarak kolik, ateş, gut ve romatizma için terapötik bir ajan olarak kullanılmaktadır. Bu araştırma ile Jurinea brevicaulis Boiss’in uçucu bileşenlerinin analiz edilmesi, fenolik bileşiklerinin belirlenmesi ve α-amilaz, α-glukozidaz ve lipaz inhibitör etkilerinin değerlendirilmesi amaçlanmıştır. Jurinae brevicaulis’in uçucu bileşenlerinin Gaz Kromatografisi-Kütle Spektrometresi (GC/MS) analizi için katı-faz mikro ekstraksiyon tekniği (SPME) kullanılmıştır. Jurinae brevicaulis’in fenolik bileşiklerinin kantitatif analizi, Yüksek performanslı ters faz sıvı kromatografisi (RP-HPLC) kullanılarak yapılmıştır. Toplam 19 uçucu bileşen belirlenmiş ve farklı terpenler için o-simen (%10.60), β-bisabolen (%9,30) ve seskisinol (%57,5) ana bileşenler olarak tanımlanmıştır. Tür için RP-HPLC analizine göre sinapik asit, p-kumarik asit ve kuersetin belirlenmiştir. Türün IC50 değerleri α-amilaz ve α-glukozidaz deneyleri için sırasıyla 36,59 ± 2,37 μg/mL ve 42,56 ± 2,83 μg/mL olarak bulunmuştur. Lipaz inhibisyon IC50 değeri 50,31 ± 3,75 μg/mL bulunmuştur. Sonuç olarak, J. brevicaulis'in antiobezite etki potansiyeline sahip üç fenolik bileşik içerdiği, bunun da J. brevicaulis'i obeziteye karşı kullanılacak doğal ürün kaynağı olarak gelecek vadeden bir aday olarak öne çıkardığı belirlenmiştir.

References

  • 1. Abudayyak, M., Kanbolat, Ş., Batur, Ş., Ergene, R.S. & Aliyazıcıoğlu, R. 2020. The biological activity; cytotoxicity and antioxidant activity of Jurinea brevicaulis. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 1(1): 1-14.
  • 2. Alam, M.A., Subhan, N., Hossain, H., Hossain, M., Reza, H.M., Rahman, M.M. & Ullah, M. 2016. Hydroxycinnamic acid derivatives: a potential class of natural compounds for the management of lipid metabolism and obesity. Nutrition & Metabolism, 13(1): 1-13.
  • 3. Alaofi, A.L. 2020. Sinapic acid ameliorates the progression of streptozotocin (stz)-induced diabetic nephropathy in rats via NRF2/HO-1 mediated pathways. Frontiers in Pharmacology, 11: 1-11.
  • 4. Bhardwaj, M., Yadav, P., Vashishth, D., Sharma, K., Kumar, A., Chahal, J., Dalal, S. & Kataria, S.K. 2021. A review on obesity management through natural compounds and a green nanomedicine-based approach. Molecules, 26(11): 3278.
  • 5. Bahadori, M.B., Zengin, G., Bahadori, S., Maggi, F. & Dinparast, L. 2017. Chemical composition of essential oil, antioxidant, antidiabetic, antiobesity, and neuroprotective properties of Prangos gaubae. Natural Product Communications, 12(12): 1945-1948.
  • 6. Bicchi, C., Liberto, E., Matteodo, M., Sgorbini, B., Mondello, L., Zellner, B.D.A., Costa, R. & Rubiolo, P. 2008. Quantitative analysis of essential oils: a complex task. Flavour and Fragrance Journal, 23: 382-391.
  • 7. Blüher, M. 2019. Obesity: global epidemiology and pathogenesis. Nature Reviews Endocrinology, 15: 288-298.
  • 8. Bustanji, Y., Al-Masri, I.M., Mohammad, M., Hudaib, M., Tawaha, K., Tarazi, H. & Alkhatib, H.S. 2011. Pancreatic lipase inhibition activity of trilactone terpenes of Ginkgo biloba. Journal of Enzyme Inhibition and Medicinal Chemistry, 26: 453-459.
  • 9. Calixto, J.B. 2019. The role of natural products in modern drug discovery. Anais da Academia Brasileira de Ciências, 91: 1-7.
  • 10. Dirar, A.I., Alsaadi, D.H.M., Wada, M., Mohamed, M.A., Watanabe, T. & Devkota, H.P. 2019. Effects of extraction solvents on total phenolic and flavonoid contents and biological activities of extracts from Sudanese medicinal plants. South African Journal of Botany, 120: 261-267.
  • 11. Dosoky, N.S. & Setzer, W.N. 2018. Chemical composition and biological activities of essential oils of Curcuma species. Nutrients, 10: 1-42.
  • 12. Dumaa, M., Gruner, M., Tilo, L., Solongo, T., Chunsriimyatav, G. & Knolker, H.J. 2018. Phytochemical study of Jurinea mongolica Maxim. Bulletin of the Institute of Chemistry and Chemical Technology, 6: 53-58.
  • 13. Endalifer, M.L. & Diress, G. 2020. Epidemiology, predisposing factors, biomarkers, and prevention mechanism of obesity. Journal of Obesity, 2020: 1-8.
  • 14. George, G., Sridhar, S.N.C. & Paul, A.T. 2020. Investigation of synergistic potential of green tea polyphenols and orlistat combinations using pancreatic lipase assay-based synergy directed fractionation strategy. South African Journal of Botany, 135: 50-57.
  • 15. Ghouse, M.S., Barwal, S.B. & Wattamwar, A.S. 2016. A Review on obesity. Health Science Journals, 10(4): 1-5.
  • 16. Han, X., Guo, J., You, Y., Zhan, J. & Hang, W. 2020. p-Coumaric acid prevents obesity via activating thermogenesis in brown adipose tissue mediated by mTORC1-RPS6. FASEB Journal, 34: 7810-7824.
  • 17. Jack, B.U., Malherbe, C.J., Huisamen, B., Gabuza, K., Mazibuko-Mbeje, S., Schulze, A.E., Joubert, E., Muller, C.J.F., Louw, J. & Pheiffer, C. 2017. A polyphenol-enriched fraction of Cyclopia intermedia decreases lipid content in 3T3-L1 adipocytes and reduces body weight gain of obese db/db mice. South African Journal of Botany, 110: 216-229.
  • 18. Jawed, A., Singh, G., Kohli, S., Sumera, A., Haque, S., Prasad, R. & Paul, D. 2019. Therapeutic role of lipases and lipase inhibitors derived from natural resources for remedies against metabolic disorders and lifestyle diseases. South African Journal of Botany, 120: 25-32.
  • 19. Jeong, E.Y., Cho, K.S. & Lee, H.S. 2012. α-amylase and α-glucosidase inhibitors isolated from Triticum aestivum L. sprouts. Journal of the Korean Society for Applied Biological Chemistry, 55: 47-51.
  • 20. Kanbolat, S., Korkmaz, N., Sener, S.O., Badem, M., Colak, N.U., Abudayyak, M., Aliyazicioglu, R., Ozgen, U., Kandemir, A. & Karaoglu, S.A. 2018. Antioxidant, antimicrobial, cytotoxic, anticholinesterase, antityrosinase activities and characterisation of volatile compounds of Verbascum oocarpum by SPME and GC-FID/MS. Journal of Pharmaceutical Research International, 24: 1-12.
  • 21. Karamać, M. & Amarowicz, R. 1996. Inhibition of pancreatic lipase by phenolic acids - examination in vitro. Zeitschrift für Naturforschung - Section C Journal of Biosciences, 51: 903-906.
  • 22. Korkmaz, N., Sener, S.O., Akkaya, S., Badem, M., Aliyazicioglu, R., Abudayyak, M., Oztas, E. & Ozgen, U. 2019. Investigation of antioxidant, cytotoxic, tyrosinase inhibitory activities, and phenolic profiles of green, white, and black teas. Turkish Journal of Biochemistry, 44(3): 278-288.
  • 23. Kumar, A. & Agnihotri, V.K. 2020. Phytochemical studies of Jurinea macrocephala roots from Western Himalaya. Natural Product Research, 34: 421-424. https://doi.org/10.1080/14786419.2018.1530233
  • 24. Liu, T.T., Liu, X.T., Chen, Q.X. & Shi, Y. 2020. Lipase inhibitors for obesity: a review. Biomedicine & Pharmacotherapy, 128: 1-9.
  • 25. Mahmood, N. 2016. A review of α-amylase inhibitors on weight loss and glycemic control in pathological state such as obesity and diabetes. Comparative Clinical Pathology, 25: 1253-1264.
  • 26. Marrelli, M., Loizzo, M.R., Nicoletti, M., Menichini, F. & Conforti, F. 2013. Inhibition of key enzymes linked to obesity by preparations from mediterranean dietary plants: effects on α-amylase and pancreatic lipase activities. Plant Foods for Human Nutrition, 68: 340-346.
  • 27. Mohamed, G.A., Ibrahim, S.R., Elkhayat, E.S. & El Dine, R.S. 2014. Natural anti-obesity agents. Bulletin of Faculty of Pharmacy, 52: 269-284.
  • 28. Palanisamy, U.D., Ling, L.T., Manaharan, T. & Appleton, D. 2011. Rapid isolation of geraniin from Nephelium lappaceum rind waste and its anti-hyperglycemic activity. Food Chemistry, 127: 21-27.
  • 29. Park, J.Y., Kim, C.S., Park, K.M. & Chang, P.S. 2019. Inhibitory characteristics of flavonol-3-O-glycosides from Polygonum aviculare L. (Common knotgrass) against porcine pancreatic lipase. Scientific Reports, 9: 1-10.
  • 30. Ragab, S.M.M., Abd Elghaffar, S.K., El-Metwally, T.H., Badr, G., Mahmoud, M.H. & Omar, H.M. 2015. Effect of a high fat, high sucrose diet on the promotion of non-alcoholic fatty liver disease in male rats: The ameliorative role of three natural compounds. Lipids in Health and Disease, 14: 1-11.
  • 31. Rashed, A.A., Mohd Nawi, M.N. & Sulaiman, K. 2017. Assessment of essential oil as a potential anti-obesity agent: a narrative review. Journal of Essential Oil Research, 29: 1-10.
  • 32. Rustaiyan, A. & Taherkhnai, M. 2013. Composition of the essential oil of Jurinea leptoloba growing wild in Iran. Journal of the British Association for the Study of Religions, 3: 708-710.
  • 33. Sergent, T., Vanderstraeten, J., Winand, J., Beguin, P. & Schneider, Y.J. 2012. Phenolic compounds and plant extracts as potential natural anti-obesity substances. Food Chemistry, 135: 68-73.
  • 34. Shah, N.A., Khan, M.R., Naz, K. & Khan, M.A. 2014. Antioxidant potential, DNA protection, and HPLC-DAD analysis of neglected medicinal Jurinea dolomiaea roots. BioMed Research International, 2014: 1-10.
  • 35. Singh, G., Suresh, S., Bayineni, V.K. & Kadeppagari, R.K. 2015. Lipase inhibitors from plants and their medical applications. International Journal of Pharmacy and Pharmaceutical Sciences, 7(1): 1-5.
  • 36. Singh, P., Singh, R., Sati, N., Sati, O.P. & Kumar, N. 2016. A review of genus: Jurinea. International Journal of Life-Sciences Scientific Research, 2: 23-30.
  • 37. Sukhev, S. & Singh, K.S. 2013. Therapeutic role of phytomedicines on obesity: importance of herbal pancreatic lipase inhibitors. International Research Journal of Medicine and Medical Sciences, 1: 15-26.
  • 38. Susanna, A., Garcia-Jacas, N., Hidalgo, O., Vilatersana, R. & Garnatje, T. 2006. The cardueae (Compositae) revisited: insights from ITS, trnL-trnF, and matK nuclear and chloroplast DNA analysis. Annals of the Missouri Botanical Garden, 93: 150-171.
  • 39. Tadera, K., Minami, Y., Takamatsu, K. & Matsuoka, T. 2006. Inhibition of α-glucosidase and α-amylase by flavonoids. Journal of Nutritional Science and Vitaminology, 52: 149-153.
  • 40. Trendafilova, A., Todorova, M., Kutova, N., & Guncheva, M. 2018. Phytochemical profile and anti-lipase activity of balkan endemic Jurinea tzar-ferdinandii. Natural Product Communications, 13(8): 1934578X1801300823.
  • 41. Tucci, S. 2010. The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 3: 125-143.
  • 42. Xiong, Y., Ng, K., Zhang, P., Warner, R.D., Shen, S., Tang, H.Y., Liang, Z. & Fang, Z. 2020. In vitro α-glucosidase and α-amylase inhibitory activities of free and bound phenolic extracts from the bran and kernel fractions of five sorghum grain genotypes. Foods, 9: 1301-1318.
  • 43. Yang, X.W., Huang, M.Z., Jin, Y.S., Sun, L.N., Song, Y. & Chen, H.S. 2012. Phenolics from Bidens bipinnata and their amylase inhibitory properties. Fitoterapia, 83: 1169-1175.
  • 44. Yen, G.C., Cheng, H.L., Lin, L.Y., Chen, S.C. & Hsu, C.L. 2020. The potential role of phenolic compounds on modulating gut microbiota in obesity. Journal of Food and Drug Analysis, 28: 1-11.
  • 45. Zhang, B.W., Xing, Y., Wen, C., Yu, X.X., Sun, W.L., Xiu, Z.L. & Dong, Y.S. 2017. Pentacyclic triterpenes as α-glucosidase and α-amylase inhibitors: Structure-activity relationships and the synergism with acarbose. Bioorganic & Medicinal Chemistry letters, 27(22): 5065-5070.
  • 46. Zhao, X., Chen, Q., Lu, T., Wei, F., Yang, Y., Xie, D., Wang, H. & Tian, M. 2020. Chemical composition, antibacterial, anti-inflammatory, and enzyme inhibitory activities of essential oil from Rhynchanthus beesianus rhizome. Molecules, 26: 167-179.
There are 46 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences
Journal Section Research Article/Araştırma Makalesi
Authors

Sıla Sener 0000-0001-7679-7165

Şeyda Kanbolat 0000-0001-7261-7067

Nevin Ulaş Çolak 0000-0003-3200-6688

Merve Badem 0000-0002-1265-5616

Rezzan Aliyazıcıoğlu 0000-0003-0143-8795

Ufuk Özgen 0000-0001-9839-6717

Ali Kandemir 0000-0002-0096-9204

Publication Date April 15, 2023
Submission Date December 27, 2022
Acceptance Date March 17, 2023
Published in Issue Year 2023

Cite

APA Sener, S., Kanbolat, Ş., Ulaş Çolak, N., Badem, M., et al. (2023). α-AMYLASE, α-GLUCOSIDASE AND LIPASE INHIBITORY PROPERTIES AND PHYTOCHEMICAL ANALYSIS OF ENDEMIC PLANT Jurinea brevicaulis Boiss. Trakya University Journal of Natural Sciences, 24(1), 41-49. https://doi.org/10.23902/trkjnat.1211654
AMA Sener S, Kanbolat Ş, Ulaş Çolak N, Badem M, Aliyazıcıoğlu R, Özgen U, Kandemir A. α-AMYLASE, α-GLUCOSIDASE AND LIPASE INHIBITORY PROPERTIES AND PHYTOCHEMICAL ANALYSIS OF ENDEMIC PLANT Jurinea brevicaulis Boiss. Trakya Univ J Nat Sci. April 2023;24(1):41-49. doi:10.23902/trkjnat.1211654
Chicago Sener, Sıla, Şeyda Kanbolat, Nevin Ulaş Çolak, Merve Badem, Rezzan Aliyazıcıoğlu, Ufuk Özgen, and Ali Kandemir. “ α-GLUCOSIDASE AND LIPASE INHIBITORY PROPERTIES AND PHYTOCHEMICAL ANALYSIS OF ENDEMIC PLANT Jurinea Brevicaulis Boiss”. Trakya University Journal of Natural Sciences 24, no. 1 (April 2023): 41-49. https://doi.org/10.23902/trkjnat.1211654.
EndNote Sener S, Kanbolat Ş, Ulaş Çolak N, Badem M, Aliyazıcıoğlu R, Özgen U, Kandemir A (April 1, 2023) α-AMYLASE, α-GLUCOSIDASE AND LIPASE INHIBITORY PROPERTIES AND PHYTOCHEMICAL ANALYSIS OF ENDEMIC PLANT Jurinea brevicaulis Boiss. Trakya University Journal of Natural Sciences 24 1 41–49.
IEEE S. Sener, Ş. Kanbolat, N. Ulaş Çolak, M. Badem, R. Aliyazıcıoğlu, U. Özgen, and A. Kandemir, “ α-GLUCOSIDASE AND LIPASE INHIBITORY PROPERTIES AND PHYTOCHEMICAL ANALYSIS OF ENDEMIC PLANT Jurinea brevicaulis Boiss”., Trakya Univ J Nat Sci, vol. 24, no. 1, pp. 41–49, 2023, doi: 10.23902/trkjnat.1211654.
ISNAD Sener, Sıla et al. “ α-GLUCOSIDASE AND LIPASE INHIBITORY PROPERTIES AND PHYTOCHEMICAL ANALYSIS OF ENDEMIC PLANT Jurinea Brevicaulis Boiss”. Trakya University Journal of Natural Sciences 24/1 (April 2023), 41-49. https://doi.org/10.23902/trkjnat.1211654.
JAMA Sener S, Kanbolat Ş, Ulaş Çolak N, Badem M, Aliyazıcıoğlu R, Özgen U, Kandemir A. α-AMYLASE, α-GLUCOSIDASE AND LIPASE INHIBITORY PROPERTIES AND PHYTOCHEMICAL ANALYSIS OF ENDEMIC PLANT Jurinea brevicaulis Boiss. Trakya Univ J Nat Sci. 2023;24:41–49.
MLA Sener, Sıla et al. “ α-GLUCOSIDASE AND LIPASE INHIBITORY PROPERTIES AND PHYTOCHEMICAL ANALYSIS OF ENDEMIC PLANT Jurinea Brevicaulis Boiss”. Trakya University Journal of Natural Sciences, vol. 24, no. 1, 2023, pp. 41-49, doi:10.23902/trkjnat.1211654.
Vancouver Sener S, Kanbolat Ş, Ulaş Çolak N, Badem M, Aliyazıcıoğlu R, Özgen U, Kandemir A. α-AMYLASE, α-GLUCOSIDASE AND LIPASE INHIBITORY PROPERTIES AND PHYTOCHEMICAL ANALYSIS OF ENDEMIC PLANT Jurinea brevicaulis Boiss. Trakya Univ J Nat Sci. 2023;24(1):41-9.

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