Review
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Year 2019, Special Issue: Stem Cell, 55 - 61, 01.02.2019
https://doi.org/10.23902/trkjnat.486558

Abstract



Son
yıllarda yapılan araştırmalar; birçok tümörün az miktarda da olsa kök hücre
benzeri özellik içeren hücreler, bir diğer değişle kanser kök hücreleri içerdiğini
göstermektedir. Kanser kök hücreleri ile ilgili araştırmalar ve buna bağlı
ortaya çıkan son derece hızlı gelişmeler; gerek hekimlerin gerekse bilim
insanlarının bir diğer önemli konu üzerinde yoğun şekilde çalışmaya
başlamalarına sebep olmuştur: Kanser kök hücrelerini hedef alan yeni tedavi
stratejilerinin geliştirilmesi. Bu alandaki araştırmaların sonuçları; kanserin
invazyonu, metastazı ve tekrarlamasını önlemede kanser kök hücrelerini hedef
alan tedavi yaklaşımlarının son derece başarılı olabileceğini ortaya
koymaktadır.



Karaciğer
kanseri; tüm kanser türleri arasında 5. sırada yer almaktadır. Kansere bağlı
ölümlerde ise 3. sırada yer almaktadır. Hepatosellüler karsinomanın
ilerlemesinde kanser kök hücrelerinin çok önemli rolü olduğu gösterilmiştir.
Karaciğer kanser kök hücrelerinin tanımlanması, diğer tümör hücrelerinden ayrılabilmesi
ve bu hücreleri hedef alan yeni tedavi şekillerinin geliştirilebilmesi
konularında çok önemli gelişmeler vardır. Bu derlemede; son yıllarda bu
alanlarda yapılan çalışmalar esas alınarak karaciğer kanser kök hücrelerinin
özellikleri ve bu hücreleri hedef alan yeni tedavi yaklaşımları özetlenmektedir.






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  • Aktas, R.G. & Tok, O.E. 2015. Localization of embryonic stem cell markers (Oct4, Nanog, Sox2, SSEA-4, TRA-1) in tumour spheroids of hepatocellular carcinoma cell line after confluency in long-term cell cultures. 2nd International Congress on Stem Cell and Cellular Therapies, 15-18, October, Antalya, Turkey.
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LIVER CANCER STEM CELLS

Year 2019, Special Issue: Stem Cell, 55 - 61, 01.02.2019
https://doi.org/10.23902/trkjnat.486558

Abstract

Recent studies have shown
that many tumours are containing small population of stem cell-like cells, in
other words, cancer stem cells. The rapid development of the cancer stem cell
field has allowed the scientists and the clinicians to focus on another challenge,
which targets cancer stem cells for new therapeutic strategies. Studies showed
that novel therapeutic approaches on the selective targeting of cancer stem
cells might be extremely successful for prevention of invasion, metastasis, and
the
relapses
of tumors.



Liver cancer is the 5th
most common cancer type. It has also been reported as the third most common
cause of cancer related death. Recently, progression of hepatocellular
carcinoma is thought to be driven by cancer stem cells. There are tremendous efforts
to clarify the features of liver cancer stem cells, to identify them within
other tumor cells, and finally to develop the new therapeutic models that
target those cells. This review summarizes the features of liver cancer stem
cells, and its importance for therapeutic approaches.

References

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  • Aktas, R.G. & Tok, O.E. 2015. Localization of embryonic stem cell markers (Oct4, Nanog, Sox2, SSEA-4, TRA-1) in tumour spheroids of hepatocellular carcinoma cell line after confluency in long-term cell cultures. 2nd International Congress on Stem Cell and Cellular Therapies, 15-18, October, Antalya, Turkey.
  • Alison, M.R. 2005. Liver stem cells: implications for hepatocarcinogenesis. Stem Cell Reviews, 1(3): 253-60.
  • Bach, P., Abel, T., Hoffmann, C., Gal, Z., Braun, G., Voelker, I., Ball, C.R., Johnston, I.C., Lauer, U.M., Herold-Mende, C., Mühle-bach, M.D., Glimm, H. & Buchholz, C.J. 2013. Specific elimination of CD133+ tumor cells with targeted oncolytic measles virus. Cancer Research, 73(2): 865-874.
  • De Boer, C.J., van Krieken, J.H., Janssen-van Rhijn, C.M. & Litvinov, S.V. Expression of Ep-CAM in normal, regenerating, metaplastic, and neoplastic liver. The Journal of Pathology, 188: 201-206.
  • Bowen K.N. & Monga S.P.S. 2008. Wnt/b-catenin signaling in hepatic organogenesis. Organogenesis, 4(2): 92-99.
  • Budhu, A. 2006. Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell, 10(2): 99-111.
  • Castelli, G., Pelosi, E. & Testa U. 2017. Liver cancer: Molecular characterization, clonal evolution and cancer stem cells. Cancers (Basel), 9(9): 127-73.
  • Chang, Y.W., Su Y.J. & Hsiao, M. 2015. Diverse targets of β-catenin during the epithelial-mesenchymal transition define cancer stem cells and predict disease relapse. Cancer Research. 75(16): 3398-3410.
  • Chiba, T., Kamiya, A., Yokosuka, O. & Iwam, A. 2009. Cancer stem cells in hepatocellular carcinoma: Recent progress and perspective. Cancer Letters, 286: 145-153.
  • Fan, Q. M., Jing, Y. Y., Yu, G. F., Kou, X. R., Ye, F. & Gao, L. 2014. Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial-mesenchymal transition in hepatocellular carcinoma. Cancer Letters, 352, 160-168.
  • Gao, Y., Ruan, B., Liu, W., Wang, J., Yang, X., Zhang, Z., Li,X., Duan, J., Zhang, F. & Ding, R. 2015. Knockdown of CD44 inhibits the invasion and metastasis of hepatocellular carcinoma both in vitro and in vivo by reversing epithelial-mesenchymal transition. Oncotarget, 6: 7828-7837.
  • Gedaly, R., Galuppo, R., Daily, M.F., Shah, M., Maynard, E., Chen, C., Zhang, X., Esser, K.A., Cohen, D.A., Evers, B.M., Jiang, J. & Spear, B.T. 2014. Targeting the Wnt/β-catenin signaling pathway in liver cancer stem cells and hepatocellular carcinoma cell lines with FH535. PLoS One, 9(6): e99272.
  • Haraguchi, N., Ishii, H., Mimori, K., Tanaka, F., Ohkuma, M., Kim, H.M., Akita, H., Takiuchi, D., Hatano, H., Nagano, H., Barnard, G.F., Doki, Y. & Mori, M. 2010. CD13 is a therapeutic target in human liver cancer stem cells. The Journal of Clinical Investigation, 120(9): 3326-3339.
  • Hussain, S.P., Schwank, J., Staib, F., Wang, X.W. & Harris, C.C. 2007. TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer. Oncogene, 26(15): 2166-2176.
  • Isan, H., Akbulut, Z., Cakil, Y.D. & Aktas R.G. 2018. The Relationship Between Cancer Stem Cells, Epithelial Mesenchymal Transition and Microenvironment Containing Type I Collagen During Proliferation and Differentiation Stages of Hepatocellular Carcinoma Cells. 10th International Heinrich F. C. Behr-Symposium on Stem Cells and Cancer. Abstract Book, 86.
  • Ishimoto, T. 2011. CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(–) and thereby promotes tumor growth. Cancer Cell, 19(3): 387-400.
  • Ishizaki, Y., Ikeda, S., Fujimori, M., Shimizu, Y., Kurihara, T., Itamoto, T., Kikuchi, A., Okajima, M. & Asahara, T. 2004. Immunohistochemical analysis and mutational analyses of beta-catenin, Axin family and APC genes in hepatocellular carcinomas. International Journal of Oncology, 24: 1077-1083.
  • Islam, F., Gopalan, V., Smith, R.A. & Lam, A.K. 2015. Translational potential of cancer stem cells: A review of the detection of cancer stem cells and their roles in cancer recurrence and cancer treatment. Experimental Cell Research, 335(1): 135-47.
  • Kitisin, K., Shetty, K., Mishra, L. & Johnson, L.B. 2007. Hepatocellular stem cells. Cancer Biomark, 3: 251-262.
  • Koike, H. & Taniguchi, H. 2012. Characteristics of hepatic stem/progenitor cells in the fetal and adult liver. Journal of Hepato-Biliary-Pancreatic Sciences, 19(6): 587-593.
  • Lee, T.K., Castilho, A., Cheung, V.C., Tang, K.H., Ma, S. & Ng, I.O. 2011 (a). CD24(+) liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3- mediated NANOG regulation. Cell Stem Cell, 9(1): 50-63.
  • Lee, T.K., Castilho, A., Cheung, V.C., Tang, K.H., Ma, S. & Ng, I.O. 2011 (b). Lupeol targets liver tumor-initiating cells through phosphatase and tensin homolog modulation. Hepatology, 53: 160-170.
  • Lim, R., Knight, B., Patel, K., McHutchison, J.G., Yeoh, G.C. & Olynyk, J.K. 2006. Antiproliferative effects of interferon alpha on hepatic progenitor cells in vitro and in vivo. Hepatology, 43(5): 1074-83.
  • Lin, C.Y. 2014. Differentiation Therapy with Cancer Stem Cells. Journal of Stem Cell Research & Therapeutics, 4(1): e117.
  • Lin, L., Amin, R., Gallicano, G.I., Glasgow, E., Jogunoori, W., Jessup, J.M., Zasloff, M., Marshall, J.L., Shetty, K., Johnson, L., Mishra, L. & He, A.R. 2009. The STAT3 inhibitor NSC 74859 is effective in hepato-cellular cancers with disrupted TGF-beta signaling, Oncogene, 28: 961-972.
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There are 68 citations in total.

Details

Primary Language English
Subjects Structural Biology
Journal Section Review/Derleme
Authors

Ranan Aktas 0000-0002-4474-7371

Publication Date February 1, 2019
Submission Date November 22, 2018
Acceptance Date January 22, 2019
Published in Issue Year 2019 Special Issue: Stem Cell

Cite

APA Aktas, R. (2019). LIVER CANCER STEM CELLS. Trakya University Journal of Natural Sciences, 20, 55-61. https://doi.org/10.23902/trkjnat.486558
AMA Aktas R. LIVER CANCER STEM CELLS. Trakya Univ J Nat Sci. February 2019;20:55-61. doi:10.23902/trkjnat.486558
Chicago Aktas, Ranan. “LIVER CANCER STEM CELLS”. Trakya University Journal of Natural Sciences 20, February (February 2019): 55-61. https://doi.org/10.23902/trkjnat.486558.
EndNote Aktas R (February 1, 2019) LIVER CANCER STEM CELLS. Trakya University Journal of Natural Sciences 20 55–61.
IEEE R. Aktas, “LIVER CANCER STEM CELLS”, Trakya Univ J Nat Sci, vol. 20, pp. 55–61, 2019, doi: 10.23902/trkjnat.486558.
ISNAD Aktas, Ranan. “LIVER CANCER STEM CELLS”. Trakya University Journal of Natural Sciences 20 (February 2019), 55-61. https://doi.org/10.23902/trkjnat.486558.
JAMA Aktas R. LIVER CANCER STEM CELLS. Trakya Univ J Nat Sci. 2019;20:55–61.
MLA Aktas, Ranan. “LIVER CANCER STEM CELLS”. Trakya University Journal of Natural Sciences, vol. 20, 2019, pp. 55-61, doi:10.23902/trkjnat.486558.
Vancouver Aktas R. LIVER CANCER STEM CELLS. Trakya Univ J Nat Sci. 2019;20:55-61.

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