Investigation of epicardial adipose tissue index in coronary artery disease

Abstract

Objectives: The relationship between epicardial adipose tissue thickness (EFT) and coronary artery disease (CAD) has been the subject of many studies. The relationship between them was shown, but due to the wide range of results obtained, a certain cutoff value could not be shown as a risk indicator. In our study, we aimed to obtain a more sensitive CAD risk marker by indexing epicardial adipose tissue to anthropometric measurements such as body fat ratio and body mass index (BMI). Methods: In the study, 40 people were included in the CAD group and 25 people were included in the control group. The body fat ratio and fat distribution of the participants were analyzed using the bioimpedance device. Epicardial adipose tissue thickness was obtained from the parasternal long axis by transthoracic echocardiography. The indices obtained by the ratio of epicardial adipose tissue thickness to anthropometric measurements were compared between participants with and without coronary artery disease. Results: Epicardial adipose tissue thickness was 6.09±0.9 mm in the CAD group and 5.61±1 mm in the control group (p=0.049). Sensitivity of 76.3% and specificity of 59.3% were obtained for EFT (AUC= 0.688, 95% CI 0.549-0.826). The sensitivity for the EFT/BMI ratio was 78.4%, and the specificity was 60.7% (AUC= 0.744; 95% CI 0.617-0.871). Sensitivity for EFT/body fat ratio was 81.6%, specificity 66.7% (AUC=0.846; 95% CI 0.742-0.950). Conclusion: EFT can be used as a more sensitive risk marker together with BMI or body fat ratio.

Keywords

• bioimpedance
• body mass index
• coronary artery disease
• epicardial adipose tissue

Koroner arter hastalığında epikardiyal yağ doku indeksinin araştırılması

Abstract

Amaç: Epikardiyal yağ dokusu (EYD) kalınlığı ile koroner arter hastalığı (KAH) arasındaki ilişki birçok çalışmaya konu olmuştur. Aralarındaki ilişki gösterilmiş fakat elde edilen sonuçların geniş bir aralıkta olması nedeniyle risk belirteci olarak belirli sınır değer gösterilememiştir. Çalışmamızda EYD kalınlığı vücut yağ oranı, vücut kitle indeksi (VKİ) gibi antropometrik ölçümlere orantılayarak daha hassas bir KAH risk belirteci elde etmeyi hedefledik. Yöntem: Çalışmada KAH grubuna 40 kişi, kontrol grubuna 25 kişi alınmıştır. Biyoempedans cihazı kullanılarak katılımcıların vücut yağ oranı ve yağ dağılımları analiz edilmiştir. EYD kalınlığı transtorasik ekokardiyografi ile parasternal uzun eksenden elde edilmiştir. EYD kalınlığının antropometrik ölçümlere olan oranı ile elde edilen indeksler koroner arter hastalığı olan ve olmayan katılımcılar arasında karşılaştırılmıştır. Bulgular: EYD kalınlığı KAH gurubunda 6.09±0.9 mm, kontrol grubunda ise 5.61±1 mm olarak ölçüldü (p=0.049). EYD kalınlığı için %76.3 duyarlılık ve %59.3 özgüllük değerleri elde edildi (AUC=0.688, %95 CI 0.549-0.826). EYD kalınlığı/VKİ oranı için duyarlılık %78.4 ve özgüllük %60.7 idi (AUC=0.744; %95 CI 0.617- 0.871). EYD kalınlığı/vücut yağ oranı için %81.6 duyarlılık ve %66.7 özgüllük elde edildi (AUC=0.846; %95 CI 0.742-0.950). Sonuç: EYD kalınlığı, VKİ veya vücut yağ oranıyla birlikte daha hassas bir risk belirteci olarak kullanılabilir.

Keywords

• biyoempedans
• epikardiyal yağ dokusu
• koroner arter hastalığı
• vücut kitle indeksi

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