Reversible bilateral postauricular adult seborrheic dermatitis due to sodium valproate-valproic acid combination

Year 2024, , 82 - 86, 31.05.2024

Mehmet Hamdi Örüm Dilek Örüm Osman Çevik

https://doi.org/10.55665/troiamedj.1426438

Abstract

The combination of sodium valproate-valproic acid, commonly used to treat epilepsy and bipolar disor-der, may result in cutaneous reactions. In this case report, we presented a bilateral postauricular sebor-rheic dermatitis associated with sodium valproate-valproic acid use. A sodium valproate-valproic acid combination was introduced to the therapy of a 68-year-old male patient who had been diagnosed with schizophrenia and was on clozapine in order to potentially avoid seizures associated to the medication. On the fifteenth day of drug addition, crusting appeared on the back skin of both ears of the patient. While the patient had a history of clozapine use, there was no history of sodium valproate use or similar cutaneous symptoms. The current condition was associated with the sodium valproate-valproic acid combination and the drug was discontinued. Following discontinuation of the medication, the crusting decreased and disappeared completely after two weeks. The patient's schizophrenia-related treatment was completed and he was discharged. No cutaneous reaction was observed again during follow-up. It should be noted that cutaneous reactions may be associated with the use of sodium valproate-valproic acid combination.

Keywords

Sodium valproate, valproic acid, side effects, seborrheic dermatitis

Sodyum valproat-valproik asit kombinasyonuna bağlı iki taraflı postauriküler erişkin seboreik dermatiti

Abstract

Bipolar bozukluk ve epilepsi tedavisinde sıklıkla kullanılan sodyum valproat-valproik asit kombinasyonu kutanöz reaksiyonlara neden olabilir. Bu olgu sunumunda sodyum valproat-valproik asit kullanımına bağlı gelişen iki taraflı postau-riküler seboreik dermatiti sunduk. Şizofreni tanısıyla klozapin kullanmaya başlayan 68 yaşındaki erkek hastada, klozapine bağlı olası nöbetlerin önlenmesi amacıyla tedaviye sodyum valproat-valproik asit kombinasyonu eklendi. İlaç ilavesinin onbeşinci gününde hastanın her iki kulağının arka derisinde kabuklanma oluştu. Hastanın özgeçmişinde klozapin kullanım öyküsü mevcutken, sodyum valproat kullanımı ya da benzeri kutanöz semptomu öyküsü yoktu. Mevcut durum sodyum valproat-valproik asit kombinasyonuna bağlandı ve ilaç kesildi. İlacın kesilmesini takiben kabuklanmalar azaldı ve iki hafta sonra tamamen ortadan kalktı. Hastanın şizofreni tedavisi tamamlanarak taburcu edildi. Takip sırasında yeniden herhangi bir kutanöz reaksiyon gözlenmedi. Sodyum valproat-valproik asit kombinasyonunun kullanımıyla kutanöz reaksiyonların ortaya çıkabileceği unutulmamalıdır.

Keywords

Sodium valproat, valproik asit, yan etkiler, seboreik dermatit

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