Retrospective evaluation of clinical and laboratory features of pediatric patients with Hashimoto’s thyroiditis

Abstract

Objectives: Evaluation of clinical, demographic, labora-tory, and clinical features of patients with a diagnosis of Hashimoto’s thyroiditis. Methods: This study included all patients who admitted to the Department of Child Health and Diseases, Adoles-cent and General Pediatrics polyclinics between January 1, 2012 and May 20, 2019, who had positive thyroid antibodies and were diagnosed with Hashimoto’s thy-roiditis or followed by this diagnosis. Hospital automa-tion system was scanned retrospectively. Demographic features, anthropometric measurements, growth and de-velopment status, laboratory findings and treatments of patients at the time of diagnosis were examined. Results: Among the 965 patients who were tested for thyroid autoantibodies (anti-TPO and anti-TG) between the specified dates, 83.2% (n = 79) girls and 16.8% (n = 16) boys were positive for thyroid autoantibodies and total 95 patient were included in the study. The fe-male/male ratio was 4.9. There are 75 patients who were first diagnosed and 20 patients who were previously diagnosed. The mean age of newly diagnosed patients was 10.7 ± 4.7. Additional disease is present in 43.0% of the patients. 18.6% of additional diseases are type1 diabetes mellitus, 18.6% obesity, 9.3% asthma, 9.3% anemia. Family history of Hashimoto's thyroiditis is present in 25.3% of patients. In our study, 18.9% of the patients' complaints were increased in weight gain, 11.4% were constipation, 9.4% fatigue, 9.4% menstrual irregularity and 9.4% short stature. 57 of the patients were imaged with ultrasound. In 50 of ultrasound patients (87% of ultrasound patients), findings were found which support Hashimoto's thyroiditis diagnose. 39.3% (n=35) of our patients were subclinical hypothyroidism, 12.4% (n=11) overt hypothyroidism, 12.4% (n = 11) hyperthyroidism, 36.0% (n = 32) euthyroid. In our study, a weak correlation was found between thyroid stimulating hormone and anti-thyroid peroxidase (r: 0.272, p: 0.024). Conclusion: The results of our study are similar to the literature data. Our study contributed to the literature as it is the first study to examine the demographic and labora-tory features of Hashimoto's disease in children in the Çanakkale region.

Keywords

• Adolescent
• child
• Hashimoto disease
• hypothyroidism
• autoantibodies

Hashimoto tiroiditi tanısı alan çocuk hastaların klinik ve laboratuvar özelliklerinin retrospektif olarak değerlendirilmesi

Abstract

Amaç: Çanakkale ilinde tek olan 3. Basamak has-tanemizde Hashimoto tiroiditi tanısıyla takip edilen çocuk hastaların klinik, demografik, labora-tuvar özelliklerinin değerlendirilmesi. Yöntem: Bu çalışma 1 Ocak 2012- 20 Mayıs 2019 yılları arasında Çanakkale Onsekiz Mart Üniversi-tesi Tıp Fakültesi Adölesan ve Genel Pediatri polikliniklerine başvuran ve tiroit antikorları pozitif olan ve Hashimoto tiroiditi tanısı alan veya bu tanıyla takibe gelen tüm hastalar dahil edildi. Hastane otomasyon sistemi geriye yönelik olarak tarandı. Hastaların demografik özellikleri, antropometrik ölçümleri, laboratuvar bulguları ve aldıkları tedaviler incelendi. Bulgular: Veri analizinde incelenen 965 hasta içerisinden çalışmaya 95 anti-TPO ve/veya anti-TG antikorları pozitif hasta dahil edildi. Hastala-rın %83,2’si (n=79) kız, %16,8’i (n=16) erkekti. Kız/erkek oranı 4,9. İlk tanı alan 75 hasta, daha önceden tanı konulmuş 20 hasta vardır. Yeni tanı alan hastaların ortalama yaşı 10,7±4,7 idi. Hastala-rın %43,0’ünde ek hastalık mevcuttu. Ek hastalık olarak %18,6’sı tip1 diabetes mellitus, %18,6’sı obezite, %9,3’ü astım, %9,3’ü anemi vardı. Hasta-ların %25,3’ünde Hashimoto tiroiditi için aile öyküsü pozitifti. Başvuru şikayetleri %18,9’u kilo değişimi, %11,4’ü kabızlık, %9,4’ü halsizlik, %9,4’ü adet düzensizliği ve %9,4’ü boy kısalığıy-dı. Tiroit ultrasonografi yapılanların 50’sinde (ultrasonografi yapılanların %87 si) Hashimoto tiroiditi lehine bulgu saptanmıştır. Hastalarımızın %39,3’ü (n=35) subklinik hipotiroidi, %12,4’ü (n=11) aşikar hipotiroidi, %12,4’ü (n=11) hiperti-roidi, %36,0’sı (n=32) ötiroittir. Çalışmamızda tiroit stimülan hormon ile anti-tiroit peroksidaz arasında pozitif yönlü düşük düzeyde anlamlı korelasyon saptandı (r: 0,272, p:0,024). Sonuç: Çalışmamızın sonuçları literatür verileriyle benzerlik göstermektedir. Çalışmamız Çanakkale ilinde çocuklarda Hashimoto hastalığının demog-rafik ve laboratuvar özelliklerini inceleyen ilk çalışma olması nedeniyle literatüre katkı sağlamış-tır.

Keywords

• Ergen
• çocuk
• Hashimoto hastalığı
• hipotiroidizm
• otoantikorlar

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