Zirai ilaç zehirlenmesi ile başvuran stent trombozu

Abstract

İnsanların kimyasal maddelere maruz kalması büyüyen bir endişe kaynağıdır. Glifosat bazlı herbisit (GBH) kullanımı da akut zehirlenme sonucu çeşitli hastalıklara neden olur. GBH bazlı ilaçlar sinüs bradikardisi, QT uzaması, torsade de pointes, AV blok gibi elektrokardiyografi değişikliklerine ve nadiren koroner arter trombozu neden olabilir. 2 yıl önce ilaç kaplı stent uygulanmış olan 68 yaşında erkek hasta göğüs ağrısı şikayeti ile acil servise başvurdu. Hastadan alınan anamnezde GBH içeren zirai ilaç kullanarak 2 gündür tarlada maskesiz ilaçlama yaptığı, göğüs ağrısının başladığı ve acil servise başvurduğu anlaşıldı. Akut GBH entoksikasyonu hipotansiyon, solunum sıkıntısı, gastrointestinal semptomlar, bilinç kaybı, oligüri ve nadiren ölüme neden olabilir. GBH'ye kronik maruziyetin koroner arter hastalığına neden olduğu gösterilmiştir.

Keywords

• Stent trombozu
• Zehirlenme
• glifosat bazlı herbisit

Stent thrombosis presenting with herbicide poisoning

Abstract

Human exposure to chemical pollutants is a growing concern. The use of glyphosate-based herbicide (GBH) also causes various diseases because of acute poisoning. GBH-based drugs may cause electrocardiography changes such as sinus bradycardia, QT prolongation, torsade de pointes, AV block, and rarely coronary artery thrombosis. A 68-year-old male patient, who had undergone a drug eluted stent 2 years ago, was admitted to the emergency department with chest pain. In his anamnesis, it was noted that he had been spraying weed in the field without a mask for 2 days using an agricultural drug containing GBH, and he admitted to the emergency service with chest pain. Acute GBH intoxication may cause hypotension, respiratory distress, gastrointestinal symptoms, unconsciousness, oliguria, and rarely death. It was shown that chronic exposure to GBH causes coronary artery disease.

Keywords

• Stent thrombosis
• glyphosate-based herbicide
• poisoning

References

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