An 11-year-old girl with juvenile-type granulosa cell tumor of the ovary that recurs in a short time: a case report

Abstract

Aim: Ovarian tumors with granulosa cells constitute 2-5% of all malignant ovarian tumors. Its incidence among sex cord stromal tumors is over 90%. There are two subtypes of granulosa cell tumors; adult type (95%) and juvenile type (5%). In this study, we aimed to show the recurrence of juvenile granulosa cell tumors. Case presentation: We presented a case with a diagnosis of juvenile granulosa cell tumor of the ovary, which was diagnosed at the age of 11, although it was stage 1A, but relapsed at the postoperative 14th month and underwent cytoreductive surgery. Conclusion: Although juvenile granulosa cell tumor of the prognosis is good in the early stages; it is important to follow up closely due to the risk of recurrence.

Keywords

• Juvenile granulosa cell tumor
• Ovary
• Puberty

Kısa sürede nükseden overin juvenil tip granüloza hücreli tümörü olan 11 yaşında kız hasta: olgu sunumu

Abstract

Amaç: Granüloza hücreli over tümörleri tüm malign over tümörlerinin %2-5’ini oluşturur. Seks kord stromal tümörleri arasında görülme sıklığı %90’ın üzerindedir. Granüloza hücreli tümörlerin iki alt tipi vardır; yetişkin tipi (%95) ve juvenil tipi (%5). Bu çalışmada juvenil granüloza hücreli tümörlerin nüksünü göstermeyi amaçladık. Olgu sunumu: Overin juvenil granüloza hücreli tümörü tanısıyla 11 yaşında evre 1A olmasına rağmen tanısı konulan, postoperatif 14. ayda nüks eden ve sitoredüktif cerrahi yapılan bir olguyu sunduk. Sonuç: Juvenil granüloza hücreli tümörün erken dönemde prognozu iyi olmakla birlikte; tekrarlama riski nedeniyle yakın takip önemlidir.

Keywords

• Ergenlik
• Juvenil granüloza hücreli tümör
• Yumurtalık

References

1. Busquets M, Gonzalez-Bosquet E, Muchart J et al. Granulosa cell tumor and endometrial cancer: a case report and review of the literature. Eur J Gynaecol Oncol 2010; 31:575.
2. Young RH. Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consi-deration of selected problems. Mod Pathol 2005; 18: 81.
3. Shnagar A, Alavi S, Nilipour Y et al. Massive ascites as the only sign of ovarian juvenile granulosa cell tumor in an adolescent: a case report and a review of the literature. Case Rep Oncol Med. 2013; 2013: 386725.
4. Kurihara S, Hirakawa T, Amada S et al.. Inhibin-producing ovarian granulosa cell tumor as a cause of secondary amenorrhea: case report and review of the literatüre. J Obstet Gynaecol Res 2004; 30:439-443
5. Calaminus G, Wessalowski R, Harms D et al. Juvenile granulosa cell tumors of the ovary in children and adolescents: Results from 33 patients registered in a prospective cooperative study. Gynecologic Onco-logy 1997; 65:447-452.
6. Auranen A, Sundström J, Ijäs J et al. Prognostic factors of ovarian granulosa cell tumor: a study of 35 patients and review of the literature. Int J Gynecol Cancer 2007; 17:1011.
7. Harris A, Nelson A, Watson D et al. Juvenile granulosa cell tumor: An interim report from the internatio-nal ovarian and testicular stromal tumor (OTST) registry. JCO 38, 6064-6064(2020).
8. Brown J, Shvartsman HS, Deavers MT et al. The activity of taxanes in the treatment of sex cord-stromal ovarian tumors. J Clin Oncol 2004; 22:3517.