Cervical intraepithelial neoplasia (cin) and the importance of leukocytes, platelets, mean platelet volume, platelet distribution width, red cell distribution width, plateletcrit, neutrophil/lymphocyte, platelet/lymphocyte, lymphocyte/monocyte ratios in diagnosis

Abstract

Aim: Cervical intraepithelial neoplasia (CIN) is the abnormal growth of cells on the surface of the cervix that could potentially lead to cervical cancer. In this study, we investigated whether hematological parameters, such as White Blood Cell Count (WBC), Platelet Count (PLT), Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Red Blood Cell Distribution Width (RDW), Plateletcrit (PCT), Neutrophil/Lymphocyte Ratio (NLR), Platelet/Lymphocyte Ratio (PLR), and Lymphocyte/Monocyte Ratio (LMR), which are useful in predicting the risk of developing cervical lesions. Materials and Methods: The study is retrospective. The hematological parameters (WBC, PLT, MPV, PDW, RDW, PCT, NLR, PLR, and LMR) of female patients aged 18-65, who visited the Istanbul Training and Research Hospital Gynecology and Obstetrics Clinic between 01/01/2012 and 31/12/2023, and were histologically confirmed to have CIN I, CIN II, or CIN III based on colposcopy results, were compared. These inflammatory indices were calculated based on complete blood counts taken at diagnosis. Results: When examining the comparisons made in our study, there was no significant difference in the age of patients among the CIN I, CIN II, and CIN III groups because of LEEP/Conization (p>0.05). There were no significant differences in hematological parameters; WBC, PLT, MPV, PDW, RDW, PCT values, and Neutrophil/Lymphocyte, Platelet/Lymphocyte, and Lymphocyte/Monocyte Ratios among the CIN I, CIN II, and CIN III groups (p>0.05). Conclusion: In this study, we compared hematological parameters among CIN I, CIN II, and CIN III patients to prevent overtreatment of CIN1, CIN2, and CIN3 patients and to predict the onset of invasive cervical cancer at an early stage. We did not find a significant difference. However, large-scale, multicenter studies and long-term validation are required for clinical practice.

Keywords

• Cervical Intraepithelial Neoplasia
• Lymphocyte/Monocyte
• Neutrophil/Lymphocyte
• Platelet/Lymphocyte

Supporting Institution

The authors have declared that there is no conflict of interest.

Ethical Statement

Ethical approval was obtained from the Non-Interventional Clinical Research Ethics Committee of Istanbul Training and Research Hospital with the decision number 283 dated 27.10.2023.

Servikal i̇ntraepitelyal neoplazilerde lökosit,trombosit, ortalama trombosit hacmi,trombosit dağılım genişliği, eritrosit dağılım genişliği , plateletcrit, nötrofil/lenfosit,trombosit/lenfosit, lenfosit/monosit oranı ve tanıda önemi

Abstract

Amaç: Bu çalışmanın amacı, hematolojik parametrelerin—beyaz kan hücresi sayısı (WBC), trombosit sayısı (PLT), ortalama trombosit hacmi (MPV), trombosit dağılım genişliği (PDW), kırmızı kan hücresi dağılım genişliği (RDW), trombosit krit (PCT), nötrofil/lenfosit oranı (NLR), trombosit/lenfosit oranı (PLR) ve lenfosit/monosit oranı (LMR)—servikal intraepitelyal neoplazi (CIN) riski ve CIN’in evreleri arasındaki farkları tahmin etmedeki geçerliliğini araştırmaktır. Materyal ve Yöntem: Bu retrospektif çalışmada, 1 Ocak 2012 ile 31 Aralık 2023 tarihleri arasında İstanbul Eğitim ve Araştırma Hastanesi Kadın Hastalıkları ve Doğum Kliniği’ne başvuran, yaşları 18-65 arasında değişen ve kolposkopi sonuçlarına göre histolojik olarak CIN I, CIN II veya CIN III olarak tanı konmuş kadın hastaların hematolojik parametreleri incelenmiştir. Hematolojik indeksler, tanı anında alınan tam kan sayımı sonuçlarına dayandırılmıştır. Bulgular: Çalışmamızda, CIN I, CIN II ve CIN III grupları arasında yaş açısından anlamlı bir fark bulunmamıştır (p>0,05). Ayrıca, WBC, PLT, MPV, PDW, RDW, PCT, NLR, PLR ve LMR değerleri açısından CIN I, CIN II ve CIN III grupları arasında anlamlı bir farklılık tespit edilmemiştir (p>0,05). Sonuç: Bu çalışmada, CIN I, CIN II ve CIN III evreleri arasındaki hematolojik parametrelerin anlamlı farklılıklar göstermediği bulunmuştur. Bu durum, bu parametrelerin CIN’in ilerleyişini veya invaziv servikal kanser riskini tahmin etmede güvenilir göstergeler olmayabileceğini düşündürmektedir. Gelecek araştırmalar için büyük ölçekli, çok merkezli ve uzun vadeli çalışmalar yapılması gerekmektedir.

Keywords

• Servikal İntraepitelyal Neoplazi
• Lenfosit/Monosit Oranı
• Nötrofil/Lenfosit Oranı
• Trombosit/Lenfosit Oranı

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