Prediction of Metastatic Pelvic Lymph Node Diameter For Para-aortic Lymph Node Metastasis in Patients With Locally Advanced Cervical Cancer

Year 2025, Volume: 25 Issue: 2, 33 - 39, 11.09.2025

Belma Gözde Özdemir , Fazıl Avcı , Mehmet Kulhan , Abdül Hamid Güler , Mete Can Ateş , Cetin Celik , Ahmet Bilgi

Abstract

Objectives: Investigation of the prediction of para-aortic lymph node (LN) metastasis by metastatic pelvic lymph node diameter in patients with locally advanced cervical cancer.
Methods: Between 28 December 2010 and 30 March 2021, 57 patients with locally advanced cervical cancer [2B-4A 2018 FIGO] at Selcuk University's Faculty of Medicine were enrolled in this retrospective analysis. The involvement of pelvic and para-aortic LN in patients with surgical staging and outcomes were assessed.
Results: The average age of 57 patients was 56 [33-78] years. Of patients, 73.7% were stage 2b, 12.3% were stage 3 and 14.0% were stage 4a. Of samples, 91.2% had histological type squamous cells. The mean number of LNs collected was 4 [0-49] and 10 [7-37] in patients with pelvic and para-aortic LN involvement, respectively. Para-aortic LN was positive in 9 patients and negative in 48 patients according to ROC analysis. Para-aortic LN involvement was predicted by metastatic pelvic LN cut-off diameter of 0.75 cm with 100% sensitivity and 89.6% specificity [AUC=0.959, p=0.001 [95% CI, 0.912-1.000].
Conclusion: The cut-off for pelvic LN dissection and metastatic pelvic LN diameter in locally advanced cervical cancer was accepted as 0.75 cm for predicting para-aortic LN involvement.

Keywords

cervical cancer , lenf node diameter , prediction , surgery

Ethical Statement

Necessary ethical approvals have been obtained

Supporting Institution

none

Thanks

No conflict of interest

Lokal İleri Evre Serviks Kanserinde Metastatik Pelvik Lenf Nodu Çapının Paraaortik Lenf Nodu Metastazına Yönelik Tahmini

Abstract

Amaç: Lokal ileri servikal kanserli hastalarda metastatik pelvik lenf nodu çapına göre para-aortik lenf nodu [LN] metastazının tahmininin araştırılması.
Gereç ve Yöntemler: 28 Aralık 2010 ile 30 Mart 2021 tarihleri arasında Selçuk Üniversitesi Tıp Fakültesi'nde lokal olarak ilerlemiş servikal kanserli 57 hasta [2B-4A 2018 FIGO] bu retrospektif analize dahil edildi. Cerrahi evreleme ve sonuçları olan hastalarda pelvik ve para-aortik LN tutulumu değerlendirildi.
Bulgular: 57 hastanın ortalama yaşı 56 [33-78] yıldı. Hastaların %73,7'si evre 2b, %12,3'ü evre 3 ve %14,0'ı evre 4a idi. Örneklerin %91,2'sinde histolojik tip skuamöz hücreler vardı. Pelvik ve para-aortik LN tutulumu olan hastalarda toplanan ortalama LN sayısı sırasıyla 4 [0-49] ve 10 [7-37] idi. ROC analizine göre para-aortik LN 9 hastada pozitif, 48 hastada negatifti. Para-aortik LN tutulumu %100 duyarlılık ve %89,6 özgüllük ile 0,75 cm'lik metastatik pelvik LN kesme çapı ile tahmin edildi [AUC=0,959, p=0,001 [95% CI, 0,912-1,000].
Sonuç: Lokal ileri servikal kanserde pelvik LN diseksiyonu ve metastatik pelvik LN çapı için kesme değeri, para-aortik LN tutulumunu tahmin etmek için 0,75 cm olarak kabul edildi.

Keywords

serviks kanseri , lenf nodu çapı , öngörü , cerrahi

Ethical Statement

Gerekli etik onayı alındı

Supporting Institution

Yok

Thanks

Yok

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