Research Article

Exploring the Role of Artificial Intelligence in Surgical Decision-Making in Gynecologic Oncology: A Feasibility Study

Volume: 25 Number: 3 December 25, 2025
TR EN

Exploring the Role of Artificial Intelligence in Surgical Decision-Making in Gynecologic Oncology: A Feasibility Study

Abstract

Introduction: The use of artificial intelligence (AI) applications in medical practice is rapidly increasing. When relevant data are entered, AI systems can assist healthcare professionals by providing information on triage, diagnosis, management, and surgical planning. Objective: This study aimed to evaluate the clinical relevance and feasibility of ChatGPT-4o in generating surgical recommendations for patients with gynecologic cancers, by comparing its outputs with the decisions made by experienced gynecologic oncology specialists. Methods: In this feasibility study, a total of 15 fictional case scenarios were created, including 5 cases each of endometrial cancer (EC), adnexal masses (AM), and cervical cancer (CC). These scenarios were first reviewed for appropriateness by two specialists with at least five years of experience in gynecologic oncology surgery. The cases were initially analyzed by ChatGPT-4o, which provided surgical management recommendations. Subsequently, the same scenarios were evaluated by two specialists and two fellows working at a European Society of Gynaecological Oncology (ESGO)-accredited center. The AI-generated recommendations were assessed using the Global Quality Score (GQS) system and compared with expert evaluations. Results: The surgical recommendations provided by ChatGPT-4o showed a high degree of concordance with the physicians’ decisions. The highest consistency was observed in the EC cases. Particularly in cases where management pathways were clearly defined by clinical guidelines, the AI model provided accurate suggestions. However, limited clinical insight was noted in more complex scenarios. Conclusion: This feasibility study demonstrates that ChatGPT-4o is capable of providing clinically meaningful and guideline-compliant surgical recommendations for patients with gynecologic cancers. Further studies assessing the effectiveness of AI-assisted surgical decision-making processes are warranted to better establish the clinical applicability of this model.

Keywords

Supporting Institution

This research received no external funding.

Ethical Statement

This study did not involve real patient data and was based on fictional clinical scenarios; therefore, ethics committee approval was not required.

Thanks

We would like to thank all our colleagues who supported and contributed to this study.

References

  1. Rao A, Kim J, Kamineni M, Pang M, Lie W, Dreyer KJ, Succi MD. Evaluating GPT as an Adjunct for Radiologic Decision Making: GPT-4 Versus GPT-3.5 in a Breast Imaging Pilot. J Am Coll Radiol. 2023 Oct;20(10):990-997. doi: 10.1016/j.jacr.2023.05.003. Epub 2023 Jun 21. PMID: 37356806; PMCID: PMC10733745.
  2. Yin J, Ngiam KY, Teo HH. Role of Artificial Intelligence Applications in Real-Life Clinical Practice: Systematic Review. J Med Internet Res. 2021 Apr 22;23(4):e25759. doi: 10.2196/25759. PMID: 33885365; PMCID: PMC8103304.
  3. He J, Baxter SL, Xu J, Xu J, Zhou X, Zhang K. The practical implementation of artificial intelligence technologies in medicine. Nat Med. 2019 Jan;25(1):30-36. doi: 10.1038/s41591-018-0307-0. Epub 2019 Jan 7. PMID: 30617336; PMCID: PMC6995276
  4. Levin G, Horesh N, Brezinov Y, Meyer R. Performance of ChatGPT in medical examinations: A systematic review and a meta-analysis. BJOG. 2024 Feb;131(3):378-380. doi: 10.1111/1471-0528.17641. Epub 2023 Aug 21. PMID: 37604703.
  5. Farina E, Nabhen JJ, Dacoregio MI, Batalini F, Moraes FY. An overview of artificial intelligence in oncology. Future Sci OA. 2022 Feb 10;8(4):FSO787. doi: 10.2144/fsoa-2021-0074. PMID: 35369274; PMCID: PMC8965797.
  6. Elkhader J, Elemento O. Artificial intelligence in oncology: From bench to clinic. Semin Cancer Biol. 2022 Sep;84:113-128. doi: 10.1016/j.semcancer.2021.04.013. Epub 2021 Apr 26. PMID: 33915289.
  7. Mysona DP, Kapp DS, Rohatgi A, Lee D, Mann AK, Tran P, Tran L, She JX, Chan JK. Applying Artificial Intelligence to Gynecologic Oncology: A Review. Obstet Gynecol Surv. 2021 May;76(5):292-301. doi: 10.1097/OGX.0000000000000902. PMID: 34032861.
  8. Rajpurkar P, Chen E, Banerjee O, Topol EJ. AI in health and medicine. Nat Med. 2022 Jan;28(1):31-38. doi: 10.1038/s41591-021-01614-0. Epub 2022 Jan 20. PMID: 35058619.

Details

Primary Language

English

Subjects

Gynecologic Oncology Surgery

Journal Section

Research Article

Publication Date

December 25, 2025

Submission Date

October 14, 2025

Acceptance Date

December 15, 2025

Published in Issue

Year 2025 Volume: 25 Number: 3

APA
Çaltek, N. Ç., Yassa, M., Yaman, İ., Bacaksız, A., & Temel, İ. (2025). Exploring the Role of Artificial Intelligence in Surgical Decision-Making in Gynecologic Oncology: A Feasibility Study. Türk Jinekolojik Onkoloji Dergisi, 25(3), 99-111. https://izlik.org/JA55ZJ79YM
AMA
1.Çaltek NÇ, Yassa M, Yaman İ, Bacaksız A, Temel İ. Exploring the Role of Artificial Intelligence in Surgical Decision-Making in Gynecologic Oncology: A Feasibility Study. Türk Jinekolojik Onkoloji Dergisi. 2025;25(3):99-111. https://izlik.org/JA55ZJ79YM
Chicago
Çaltek, Neçirvan Çağdaş, Mahmut Yassa, İlteriş Yaman, Ayşe Bacaksız, and İlkbal Temel. 2025. “Exploring the Role of Artificial Intelligence in Surgical Decision-Making in Gynecologic Oncology: A Feasibility Study”. Türk Jinekolojik Onkoloji Dergisi 25 (3): 99-111. https://izlik.org/JA55ZJ79YM.
EndNote
Çaltek NÇ, Yassa M, Yaman İ, Bacaksız A, Temel İ (December 1, 2025) Exploring the Role of Artificial Intelligence in Surgical Decision-Making in Gynecologic Oncology: A Feasibility Study. Türk Jinekolojik Onkoloji Dergisi 25 3 99–111.
IEEE
[1]N. Ç. Çaltek, M. Yassa, İ. Yaman, A. Bacaksız, and İ. Temel, “Exploring the Role of Artificial Intelligence in Surgical Decision-Making in Gynecologic Oncology: A Feasibility Study”, Türk Jinekolojik Onkoloji Dergisi, vol. 25, no. 3, pp. 99–111, Dec. 2025, [Online]. Available: https://izlik.org/JA55ZJ79YM
ISNAD
Çaltek, Neçirvan Çağdaş - Yassa, Mahmut - Yaman, İlteriş - Bacaksız, Ayşe - Temel, İlkbal. “Exploring the Role of Artificial Intelligence in Surgical Decision-Making in Gynecologic Oncology: A Feasibility Study”. Türk Jinekolojik Onkoloji Dergisi 25/3 (December 1, 2025): 99-111. https://izlik.org/JA55ZJ79YM.
JAMA
1.Çaltek NÇ, Yassa M, Yaman İ, Bacaksız A, Temel İ. Exploring the Role of Artificial Intelligence in Surgical Decision-Making in Gynecologic Oncology: A Feasibility Study. Türk Jinekolojik Onkoloji Dergisi. 2025;25:99–111.
MLA
Çaltek, Neçirvan Çağdaş, et al. “Exploring the Role of Artificial Intelligence in Surgical Decision-Making in Gynecologic Oncology: A Feasibility Study”. Türk Jinekolojik Onkoloji Dergisi, vol. 25, no. 3, Dec. 2025, pp. 99-111, https://izlik.org/JA55ZJ79YM.
Vancouver
1.Neçirvan Çağdaş Çaltek, Mahmut Yassa, İlteriş Yaman, Ayşe Bacaksız, İlkbal Temel. Exploring the Role of Artificial Intelligence in Surgical Decision-Making in Gynecologic Oncology: A Feasibility Study. Türk Jinekolojik Onkoloji Dergisi [Internet]. 2025 Dec. 1;25(3):99-111. Available from: https://izlik.org/JA55ZJ79YM