HPV TEST OUTCOMES OF PATIENTS WITH CERVICAL CANCER OR CERVICAL INTRAEPITHELIAL NEOPLASIA

Abstract

Aim: Human Papilloma Virüs (HPV) is the essential factor for cervical cancer. Frequency and distribution of HPV types differ among countries. In the present study, we aim to find the proportion of HPV 16/18 and also other high risk types (hrHPV) in patients with cervical intraepitelial neoplasia (CIN) and cervical cancer. Material and Methods: We reviewed clinical and pathological features of patients who had undergone colposcopic biopsy at Baskent University Hospital in Ankara between 2007-2015. Patients with the diagnosis of CIN and cervical cancer were included in the study if they had HPV test. Patients were grouped according to their HPV result. We expressed the frequencies of HPV groups based on histologic diagnosis of CIN and cervical cancer. Results: 229 patients were included in the present study. CIN 1, CIN 2, CIN 3 and cervical cancer were present in 80 (34.9 % ), 112 (48.9 % ), 30 (13.1 % ), 7 (3.1 % ) of the patients, respectively. Among 149 patients with ≥ CIN 2; HPV 16/18 was present in 77 (51.7 % ), other hrHPV types were present in 37 (24.8 % ) patients. Both HPV 16/18 and other hrHPV types were present in 18 patients (12.1% ). Conclusion: 51 % of the patients with CIN or cervical cancer have at least HPV 16 or HPV 18. This ratio was 45 % for other hrHPV types.

Keywords

• : Cervical cancer,colposcopy,smear,HPV

SERVİKS KANSERİ YA DA SERVİKAL İNTRAEPİTHELİAL NEOPLAZİ SAPTANAN HASTALARIN HPV TEST SONUÇLARI

Abstract

Amaç: Serviks kanserinin oluşumunda gerekli olan temel faktör Human Papilloma Virüs’ün (HPV) sıklığı ve dağılımı ülkelerarası toplumsal farklılıklar gösterebilmektedir. Biz bu çalışmamızda serviks kanseri ve servikal intraepithelial neoplazi (CIN) saptanan hastalarda HPV 16, 18 ve diğer hrHPV (yüksek riskli HPV) tiplerinin sıklığını ortaya koymayı amaçladık. Materyal ve Method: 2007-2015 yıllarında Başkent Üniversitesi Tıp Fakültesi Ankara Hastanesi Jinekolojik Onkoloji Cerrahisi poliklini- ğinde kolposkopik biyopsi yapılan olgular taranmıştır. Servikal intraepitelial neoplazi (CIN) ve serviks kanseri saptanan ve HPV Testi ile değerlendirilen hastalar çalışma kapsamında değerlendirilmiştir. HPV test sonucuna göre hastalar gruplandırılmıştır. CIN ve serviks kanseri saptanan hastalarda tanımlanan HPV gruplarının sayısal dağılımı gösterilmiştir. Bulgular: 229 hasta çalışma kapsamında değerlendirilmiştir. 80 (% 34.9) hastada CIN 1, 112 (% 48.9) hastada CIN 2, 30 (% 13.1) hastada CIN 3, 7 (% 3.1) hastada serviks kanseri saptanmıştır. Kolposkopik biyopsi sonucuna göre ≥ CIN 2 lezyon saptanan 149 hastadan 77’sinde (% 51.7) HPV 16/18 +, 37’ sinde (% 24.8) diğer hrHPV + tespit edilmiş olup 18 hastada (% 12.1) hem HPV 16/18 hem de diğer hrHPV tespit edilmiştir. Sonuç: CIN veya serviks kanseri olan hastaların % 51’ i en azından HPV 16 ya da 18’den birini taşımakta olup bu oran diğer hrHPV tipleri için % 45’ dir.

Keywords

• Serviks kanseri,kolposkopi,smear,HPV

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