ERKEN EVRE ORTA RİSKLİ SERVİKS KANSERİNDE CERRAHİ SONRASI ADJUVAN RADYOTERAPİ VE KEMORADYOTERAPİ

Abstract

Erken evre serviks kanseri nedeniyle opere olan ve parametrium tutulumu, lenf nodu metastazı ya da cerrahi sınır pozitişiği nedeniyle “yüksek riskli” kabul edilen hastalarda adjuvan kemoradyoterapinin hem hastalıksız hem de genel sağkalıma katkısı olduğu bilinmektedir. Ancak “orta riskli” kabul edilen olgularda adjuvan radyoterapi ile rekürrenssiz sağkalım avantajı sağlanmış olsa da genel sağkalım avantajı gösterilememiştir ve toksisitenin önemli bir sorun olduğu düşünülmektedir. Bu yazıda primer tedavi olarak radikal cerrahinin tercih edildiği hastalarda “orta risk” grubunun özellikleri ve bu grupta adjuvan radyoterapinin endikasyonları tartışılacaktır

Keywords

• Serviks Kanseri, Radyoterapi, Orta-Risk Grubu.

Abstract

Adjuvant chemoradiotherapy improves progression-free (PFS) and overall survival (OS) in “high risk” patients with early stage cervical cancer who are operated and have lymph node metastases, parametrial involvement or positive surgical margins. However, adjuvant radiotherapy was shown to improve PFS but not OS in patients with “intermediate risk” disease and toxicity of radiotherapy is of concern in this subgroup. We herein reviewed the characteristics of surgically treated early stage intermediate risk patients and discussed the indications of radiotherapy in these patients

Keywords

• Cervical Cancer, Radiotherapy, Intermediate Risk Group

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