ANTİNEOPLASTİK MARUZİYETİNİN SAĞLIK ÇALIŞANLARININ ÜREME SAĞLIĞI ÜZERİNE ETKİLERİ

Abstract

Hastanelerde bulunan çeşitli kimyasal ve ilaçlara maruz kalmanın personel sağlığı üzerindeki etkileri yaygın biçimde araştırılmaktadır. Gelişmiş ülkelerde, bu konuda yapılmış çok sayıdaki epidemiyolojik araştırmaların ışığında güvenli çalışma protokolleri geliştirilmiştir. Bu önlemler antineoplastiklerin yaygın olarak kullanıldığı onkoloji kliniği, klinik farmakoloji üniteleri ve ilgili sağlık personelini de kapsamaktadır. Araştırmalar maruziyet bulgularının önlemlere rağmen devam ettiğine işaret etmektedir. Antineoplastik ilaçların elde taşınması, hazırlanması ve hatta kemoterapi alan hastaların klinik bakımı, sorumlu personelin üreme sağlığı üzerinde olumsuz etkiler yaratabilir. Dolayısıyla ilgili birimlerde çalışan ve özellikle aktif üreme çağında olan kadın sağlık personelinin konu ile ilgili endişeleri süregelmektedir. Bu endişeler arasında düşükler ve konjenital anomaliler ilk sıraları alsa da intrauterin gelişme geriliği, ölü doğum, preterm doğum gibi etkiler de bazı çalışmalarca ileri sürülmüştür. Bu nedenle hastanelerde antineoplastik ilaçlarla çalışan kadın sağlık personelinin üreme sağlığı üzerindeki olası etkilerini literatürdeki verileri gözden geçirerek netleştirmeye çalışacağız.

Keywords

• Antineoplastik ajanlar, Üreme sağlığı, Sağlık personeli, Düşük.

EFFECTS OF OCCUPATIONAL ANTINEOPLASTIC EXPOSURE ON REPRODUCTIVE HEALTH OF HEALTHCARE PERSONNEL

Abstract

Occupational hazards have been studied in detail for their impact on healthcare workers in hospitals. In the light of many epidemiologic studies on the issue, standard safety protocols have been issued in developed countries. These protocols cover for places where routine antineoplastic medications are used, such as clinical pharmacology units, oncology clinics and for related healthcare personnel. Despite these precautions, studies continued to point exposure findings. Handling and preparation of antineoplastic medications or even caring of chemotherapy patients may cause adverse outcomes on reproductive health of personnel. Such a possibility is continued to generate significant concern among personnel who is working with antineoplastic medications, especially among female workers in their reproductive age. Even though these concerns are mainly for miscarriages and congenital anomalies, some studies have also suggested possible risks for stillbirth, intrauterine growth retardation, preterm delivery and infertility. Therefore we will attempt to clarify

Keywords

• Antineoplastic agents, Reproductive health, Healthcare personnel, Abortion

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