Erken dönemde ölüm ile sonuçlanan beyin ve kemik metastazı mevcut endometrioid tip endometrium adenokanseri: vaka sunumu

Abstract

Endometriyal kanser gelişmiş ülkelerde en sık görülen jinekolojik kanserdir. Beyin ve kemik metastazı oldukça nadir görülmektedir. 47 yaşında, gravida 1, parite 1 kadın hasta menometroraji sebebiyle yapılan endometriyal biyopside grade 2 endometriod tip endometrium kanseri tanısı almıştır. Hastanemize sevk edilmiş ve hastanemizde opere edilmiştir. Bir ay sonra, parestezi şikayeti ile acil servise başvuan hastanın beyin MR’ında çok sayıda metastatik lezyon tespit edilmiştir. Beyin radyoterapisinin tamamlanmasından sonra hastanın medical durumu kötüleşmiştir. Dispne ve kemik ağrıları şikayetleri olması üzerine toraks görüntülemesi yapılmıştır. Metastatik kemik ve akciğer lezyonları tespit edilmiştir. Hasta postoperatif 76.günde hayatını kaybetmiştir. Bildiğimiz kadarıyla bu vaka, kemik ve beyin metastazı ile seyreden literatürdeki altıncı vakadır. 

Keywords

• endometriyal kanser,beyin metastazı,kemik metastazı

Endometrioid type endometrium adenocarcinoma with brain and bone metastasis with early fatal outcome: a case report

Abstract

Endometrial cancer is the most common gynaecological cancer in developed countries and brain and bone metastasis are extremely rare. A 47-year-old, gravida 1, parity 1 woman had been diagnosed to have grade 2, endometrioid type carcinoma of the endometrium by an endometrial biopsy done for a complaint of menometrorrhagia. She was referred and operated in our hospital. One month later, she admitted to the emergency department of our hospital with paresthaesia on the right side and multiple metastatic lesions were detected in her brain MRI. After the completion of the brain radiotherapy, her medical condition were deteriorated. She had complaints of dyspnea and bone pains. Imaging of the thorax showed multiple metastatic lesions in bones and lungs. The patient was died on the 76th postoperative day. To our knowledge, this patient was the sixth case of the endometrial cancer with concomitant bone and brain metastases.

Keywords

• endometrial cancer,brain metastasis,bone metastasis

References

1. Referans1 Doger E, Cakiroglu Y, Ozdamar O, Ceylan Y, Kole E, Yucesoy I, et al. Bone metastasis in endometrial cancer: evaluation of treatment approaches by factors affecting prognosis. Eur J Gynaecol Oncol. 2016;37(3):407-16.
2. Referans2 Uccella S, Morris JM, Multinu F, Cliby WA, Podratz KC, Gostout BS, et al. Primary brain metastases of endometrial cancer: A report of 18 cases and review of the literature. Gynecol Oncol. 2016;142(1):70-5.
3. Referans3 Loizzi V, Cormio G, Cuccovillo A, Fattizzi N, Selvaggi L. Two cases of endometrial cancer diagnosis associated with bone metastasis. Gynecol Obstet Invest. 2006;61(1):49-52.
4. Referans4 Shigemitsu A, Furukawa N, Koike N, Kobayashi H. Endometrial cancer diagnosed by the presence of bone metastasis and treated with zoledronic Acid: a case report and review of the literature. Case Rep Oncol. 2010;3(3):471-6.
5. Referans5 Croucher P, Jagdev S, Coleman R. The anti-tumor potential of zoledronic acid. Breast. 2003;12 Suppl 2:S30-6.
6. Referans6 Piura E, Piura B. Brain metastases from endometrial carcinoma. ISRN Oncol. 2012;2012:581749.