Homeobox (HOX) genleri ve jinekolojik kanserler

Abstract

Homeobox (HOX) genleri bir transkripsiyon faktörü olarak, embriyonik gelişim ve kanser ilerlemesinde önemli bir rol oynar. Ayrıca dişi üreme yolunun uygun şekilde bölünmesini sağlar ve yetişkin kimliğine yol açan konumsal kimliği verir. HOX genlerinin jinekolojik kanserlerde farklı ekspresyon paterni sergilediği, diyagnostic belirteç olmanın yanı sıra prognostik belirteç olarak kullanılabileceği öngörülmektedir. HOX genlerinin jinekolojik kanserlerin onkogenezindeki rolüne ilişkin bilgilerimiz gelişmektedir. Burada HOX genlerinin insan gelişimi ve jinekolojik kanser onkogenezindeki rollerini gözden geçiriyoruz.

Keywords

• Homebox genleri
• Jinekolojik Kanserler
• Onkogenez
• Embriyogenezis

Homeobox (HOX) genes and gynecological cancers

Abstract

Homeobox (HOX) genes play a significant role as a transcription factor in embryonic development and cancer progression. In addition, it ensures appropriate division of the female reproductive tract and determines spatial identity that leads to adult identity. It has been predicted that HOX genes exhibit a different expression pattern in gynecological cancers and can be used as a prognostic marker as well as a diagnostic marker. Our scientific knowledge has broadened regarding the role of HOX genes in the oncogenesis of gynecological cancers. Here, we review the role of HOX genes in human development and oncogenesis of gynecological cancers.

Keywords

• Homebox genes
• Gynecological Cancers
• Oncogenesis
• Embryogenesis

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