Abstract
Endometrial hiperplaziler jinekoloji prati¤inde s›kça görülen bir
hastal›k grubudur. Bu grup hastalar›n klinik önemi efllik edebilecek
olan genital kanserler ve izlemde progresyon sonucu geliflebilecek
olan endometrial kanserlerdir. Tan› an›nda non-invazif metodlar kullan›larak
altta yatan kanser olgular›n› saptamaya yönelik çal›flmalar
son dönemde yo¤unlaflm›fl olsa da henüz sonuca vard›r›c› düzeyde
de¤ildir. Günümüzde kansere progresyonu gösterecek olan prognostik
faktörler üzerinde yo¤un çal›flmalar sürmekte ise de (WHO 94 vs.
EIN) halen pratik hayatta kullan›labilir ve güvenilir bir s›n›flama sistemi
bulunamam›flt›r. Endometrial hiperplazilerde tedavi hasta yafl›,
fertilite arzusu ve mevcut hiperplazinin tipine ba¤l› olarak de¤iflmektedir.
Günümüzde halen progestagenler en s›k kullan›lan medikal
tedavi modalitesidir. Atipisiz olgularda yan›t oranlar› daha yüksektir.
Seçilmifl olgularda definitif tedavi olarak histerektomi uygulan›labilir.
Bu derleme makalede endometrial hiperplazilerin güncel yönetimleri,
ilgili literatür eflli¤inde özetlenmeye çal›fl›lm›flt›r.
Abstract
Endometrial hyperplasia is a commonly seen disorder in the daily
gynecology practice. Clinical importance of these patients is the
underlying risk of carrying a concomittant genital cancer or the risk of
progression to endometrial carcinoma during the follow up. Despite
to the recent advances in the non-invasive tecniques to define the
underlying endometrial cancer during the initial admission of these
patients; neither of these studies are conclusive yet. Today; dedspite to
the intense discussions and studies related to define certain prognostic
factors (WHO 94 vs. EIN) to predict the cases who would progress
to cancer; we still do not have a practical and accurate system available
to use during daily practice. Treatment of endometrial hyperplasias
depends on the patient’s age, fertility desire and the type of
present hyperplasia. Progestagens are still the most commonly used
medical treatment modality in these patients. Response rates are higher
in cases without atypia. In selected cases, hysterectomy may be performed
as a definitive treatment modality. In this review article; current
management of the endometrial hyperplasias are summarized in
the light of associated literature
Details
| Other ID | JA39SD48KY |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | January 1, 2007 |
| Submission Date | January 1, 2007 |
| Published in Issue | Year 2007 Volume: 10 Issue: 1 |