HPV ENFEKSİYONU VE ANOGENİTAL PREİNVAZİV VE İNVAZİV LEZYONLAR

Year 2013, Volume: 16 Issue: 4Ek, 0 - 0, 01.10.2013

Faruk Aybike İlkkan Dünder

Abstract

Dünyada en sık saptanan seksüel geçişli hastalık HPV enfeksiyonudur.
HPV deri ve mukozalarda bazal membrana yakın olan hücreleri
enfekte eden DNA virusudur. HPV, cilt ve mukoz membranları
enfekte eder ve lokal epitelyal proliferasyona sebep olur. HPV epidemiyolojisi,
bölgesel olarak ve yaş gruplarına göre farklılıklar göstermektedir.
HPV, servikal kanser dışında anüs, vulva, vagina, penis, baş
boyun kanserlerinden, anogenital kondilomalar ve rekürren respiratuar
papillomatozisden sorumludur. Genital HPV enfeksiyonu, dünyada
en sık rastlanan cinsel yolla bulaşan hastalık olup tüm servikal
kanser olgularının % 99,8’de HPV varlığı tespit edilmiştir. HPV enfeksiyonu,
anogenital bölgede hemen tüm bölgenin preinvaziv ve invaziv
lezyonlarıyla ilişkili olup, günümüzde en sık rastlanan seksüel geçişli
olması nedeniyle ciddi bir toplum problem oluşturmaktadır. Ço-
ğu HPV enfeksiyonu asemptomatik seyretmesi ve tanısının zor olması
nedeniyle HPV enfeksiyonundan korunmak çok daha fazla önem
kazanmıştır. Uygun aşılama ve eğitim planlamaları ile HPV enfeksiyonundan
korunma ve ilgili preinvaziv ve invaziv hastalıkların önlenmesi
mümkün olabilecektir.

Keywords

HPV, Servikal Kanser, Preinvaziv Lezyonlar, Vulva Kanseri, Vaginal Kanser, Anogenital Kanserler.

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