VULVANIN GRANÜLER HÜCRELİ TÜMÖRÜ: OLGU SUNUMU VE LİTERATÜRÜN GÖZDEN GEÇİRİLMESİ

Year 2014, Volume: 17 Issue: 2, 0 - 0, 01.04.2014

İsmet Hortu Ahmet Mete Ergenoğlu Burak Zeybek Ali Akdemir Ahmet Özgür Yeniel

Abstract

Granüler hücreli tümörler, deride Schwann hücrelerinden geliştiği düşünülen ve oldukça ender görülen lezyonlardır. En sık başboyun
bölgesinde görülmekle birlikte, %5.3 oranında vulvar bölgede saptanabilirler. Olguların büyük çoğunluğu benign olmasına
rağmen, makroskopik olarak bu tümörlerin sınırları belirgin değildir ve çevre dokulara yapışıklık gösterebilirler. Nadir olarak
malign transformasyon bildirilmiştir. Ayrıca bu hastalarda nüks de oldukça sık görülür. Bu olgu sunumunda, 59 yaşında daha önce
meme karsinomu nedeniyle unilateral mastektomi operasyonu geçirmiş olan hastada gelişen vulvar granüler hücreli tümör güncel
tedavi yaklaşımları ile birlikte tartışılacaktır.

Keywords

Granüler hücreli tümör, vulva, meme karsinomu

GRANULER CELL TUMOR OF VULVA: A CASE REPORT AND REVIEW OF THE LITERATURE

Abstract

Granular cell tumors are unusual neoplasms presumably derived from Schwann cells. These tumors are mostly seen in head and
neck area and 5.3%of cases are localized in the vulva. Although most of the cases are benign, macroscopically they are poorly
circumscribed and show adherence to the surrounding connective tissue. Malignant transformation was also reported and
recurrence is common in these patients. In this case report, a vulvar granular cell tumor is presented and discussed in a 59-yearold
woman with a history of unilateral mastectomy due to breast cancer.

Keywords

Granular cell tumor, vulva, breast carcinoma

References

• 1. Abrikossoff A. Über Myome, ausgehend von der quergestreiften willkürlichen Muskulatur. Virchows Arch Pathol Anat Physiol 260: 215-233, 1926.
• 2. Ordonez NG, Mackay B. Granular cell tumor: a review of the pathology and histogenesis. Ultrastruct Pathol 1999; 23:207.
• 3. Horowitz IR, Copas P, Majmudar B. Granular cell tumors of the vulva. Am J Obstet Gynecol 1995; 173:1710.
• 4. Gokaslan ST, Terzakis JA and Santagada EA. Malignant granular cell tumor. J Cutan Pathol 21: 363-370, 1994.
• 5. Lack EE, Worsham GF, Callihan MD, Crawford BE, Klappenbach S, Rowden G and Chun B. Granular cell tumor: a clinicopathological study of 110 patients. J Surg Oncol 13: 301-316, 1980.
• 6. Uzoaru I, Filler B, Ray V, Hubbatd-Shepaid M and Rhee H. Malignant granular cell tumor. Arch Pathol Lab Med 116: 206, 1992.
• 7. Robboy SJ, Russell P, Anderson MC, Prat J, Mutter GL. Robboy’s Pathology of the Female Reproductive Tract. New York, NY: Elsevier Health Sciences; 2009:100.
• 8. Jida Chen, Linbo Wang, Jing Xu, Tao Pan, Jianguo Shen, Wenxian Hu and Xiaoming Yuan. Malignant granular cell tumor with breast metastasis: A case report and review of the literature. Oncology Letters 4: 63-66, 2012.
• 9. Fanburg Smith JC, Meis Kindblom JM, Fante R and Kindblom LG. Malignant granular cell tumor of soft tissue: Diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol 22: 779-794, 1998.
• 10. Enzinger RM, Weiss SW. Granular cell tumor in Soft Tissue Tumors. 4th edition. Mosby, St. Louis, pp1178-1206, 2001.
• 11. Mahoney A, Garg A, Wolpowitz D and Mahalingam M. Atypical granular cell tumor - apropos of a case with indeterminate malignant potential. Am J Dermatopathol 32: 370-373, 2010.
• 12. An JS, Han SH, Hwang SB, Lee JH, Min BW, Um JW et al. Granular cell tumors of the abdominal wall. Yonsei Med J 48(4):727–730, 2007.