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SERTOLİ LEYDİG HÜCRELİ TÜMÖR: 4 OLGU SUNUMU VE LİTERATÜRÜN GÖZDEN GEÇİRİLMESİ

Year 2014, Volume: 17 Issue: 3, 0 - 0, 01.07.2014

Abstract

Sertoli-Leydig hücreli tümörler tüm over tümörlerinin %0.5’inden azını oluştururlar. Sertoli-Leydig hücreli tümör hastanemizde
son 5 yıl içinde 4 olguda gözlendi. Olguların yaşı 25 ile 73 arasında değişmekte idi ve ortalama yaş 43 idi. Bir hasta sekonder
amenore ve virilizasyon, dört hastanın üçü ise kasık ağrısı ile başvurdu. İki hastaya total abdominal histerektomi ve bilateral
salfingoooferektomi, iki hastaya unilateral salfingoooferektomi uygulandı. Takiplerde rekürrens/metastaz saptanmadı. Bu olgular
klinikopatolojik bulguları literatür eşliğinde gözden geçirilmiştir.

References

  • 1. Haroon S, Zia A, Idrees R, Memon A, Fatima S, Kayani N. Clinicopathological spectrum of ovarian sex cordstromal tumors; 20 years’ retrospective study in a developing country. Journal of Ovarian Research 2013; 6:87
  • 2. Lantzsch T, Stoerer S, Lawrenz K, Buchmann J, Strauss HG, Koelbl H. Sertoli–Leydig cell tumor. Arch Gynecol Obstet 2001; 264(4): 206-8.
  • 3. Chia-Sui Weng a, Min-Yu Chen b,c, Tao-Yeuan Wang d, et.al. SertolieLeydig cell tumors of the ovary: A Taiwanese Gynecologic Oncology Group study. Taiwanese Journal of Obstetrics & Gynecology 2013; 52: 66-70.
  • 4. Colombo N, Peiretti M, Garbi A, Carinelli S, Marini C, Sessa C. ESMO Guidelines Working Group: Nonepithelial ovarian cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 2012; 7:20–26.
  • 5. Kommoss F, Oliva E, Bhan AK, Young RH, Scully RE. Inhibin expression in ovarian tumors and tumor-like lesions: an immunohistochemical study. Mod Pathol 1998;11: 656-64.
  • 6. Young RH, Scully RE. Ovarian SertolieLeydig cell tumors. A clinicopathological analysis of 207 cases. Am J Surg Pathol 1985; 9: 543-69.
  • 7. Gui T, Cao D, Shen K, Yang J, Zhang Y , Yu Q, et. al. A clinicopathological analysis of 40 cases of ovarian Sertoli–Leydig cell tumors. Gynecologic Oncology 2012; 127: 384–389.
  • 8. DemidovVN, Lipatenkova J, Vikhareva O, VanHolsbeke C, Timmerman D, Valentin L. Imaging of gynecological disease (2): clinical and ultrasound characteristics of Sertoli cell tumors, Sertoli-Leydig cell tumors and Leydig cell tumors. Ultrasound Obstet Gynecol 2008; 31: 85- 91.
  • 9. Gheorghisan-Galateanu A, Fica S, Terzea DC, Caragheorgheopol A, Horhoianu V. Sertoli-Leydig cell tumor e a rare androgen secreting ovarian tumor in postmenopausal women Case report and review of literature. J Cell Mol Med 2003; 7: 461-71.
  • 10. Chen L, Tunnell CD, Petris GD. Sertoli-Leydig cell tumor with heterologous element: a case report and a review of the literature. Int J Clin Exp Pathol 2014; 7(3): 1176- 1181.
  • 11. Guo L, Yang X, Zhu H, Qiu W, Shi X, Huang B, Duan T. SertolieLeydig cell tumor presenting hyperestrogenism in a postmenopausal woman: A case report and review of the literature. Taiwanese Journal of Obstetrics & Gynecology 2012; 51: 620-624.
  • 12. Gui T, Cao D, Shen K, Yang J, Zhang Y, Yu Q, Wan X, Xiang Y, Xiao Y, Guo L. A clinicopatholo gical analysis of 40 cases of ovarian Sertoli-Leydig cell tumors. Gynecol Oncol 2012; 127: 384-389.
  • 13. Sigismondi C, Gadducci A, Lorusso D, Candiani M, Breda E, Raspagliesi, et al. Ovarian Sertoli–Leydig cell tumors. A retrospective MITO study. Gynecol Oncol 2012; 125(3): 673-6.

SERTOLI LEYDIG CELL TUMOR: REPORT OF 4 CASES AND REVIEW OF THE LITERATURE

Year 2014, Volume: 17 Issue: 3, 0 - 0, 01.07.2014

Abstract

Sertoli-Leydig cell tumors constitude 0.5% of all ovarian tumors. Sertoli-Leydig cell tumor has been diagnosed in four patients in
the last 5 years period in our hospital. The ages ranged from 25 to 73 years, with a mean of 43 years. One patient presented with
secondary amenorrhea and virilization, three of the four patients showing groin pain. Histologically, four tumors were intermediated
differentiated. Two patients underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy and two were
treated by unilateral salpingo-oophorectomy. Recurrence/metastasis was not noted in all cases with follow-up data. The clinicopathologic
features of these cases are described and the relevant literature is reviewed

References

  • 1. Haroon S, Zia A, Idrees R, Memon A, Fatima S, Kayani N. Clinicopathological spectrum of ovarian sex cordstromal tumors; 20 years’ retrospective study in a developing country. Journal of Ovarian Research 2013; 6:87
  • 2. Lantzsch T, Stoerer S, Lawrenz K, Buchmann J, Strauss HG, Koelbl H. Sertoli–Leydig cell tumor. Arch Gynecol Obstet 2001; 264(4): 206-8.
  • 3. Chia-Sui Weng a, Min-Yu Chen b,c, Tao-Yeuan Wang d, et.al. SertolieLeydig cell tumors of the ovary: A Taiwanese Gynecologic Oncology Group study. Taiwanese Journal of Obstetrics & Gynecology 2013; 52: 66-70.
  • 4. Colombo N, Peiretti M, Garbi A, Carinelli S, Marini C, Sessa C. ESMO Guidelines Working Group: Nonepithelial ovarian cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 2012; 7:20–26.
  • 5. Kommoss F, Oliva E, Bhan AK, Young RH, Scully RE. Inhibin expression in ovarian tumors and tumor-like lesions: an immunohistochemical study. Mod Pathol 1998;11: 656-64.
  • 6. Young RH, Scully RE. Ovarian SertolieLeydig cell tumors. A clinicopathological analysis of 207 cases. Am J Surg Pathol 1985; 9: 543-69.
  • 7. Gui T, Cao D, Shen K, Yang J, Zhang Y , Yu Q, et. al. A clinicopathological analysis of 40 cases of ovarian Sertoli–Leydig cell tumors. Gynecologic Oncology 2012; 127: 384–389.
  • 8. DemidovVN, Lipatenkova J, Vikhareva O, VanHolsbeke C, Timmerman D, Valentin L. Imaging of gynecological disease (2): clinical and ultrasound characteristics of Sertoli cell tumors, Sertoli-Leydig cell tumors and Leydig cell tumors. Ultrasound Obstet Gynecol 2008; 31: 85- 91.
  • 9. Gheorghisan-Galateanu A, Fica S, Terzea DC, Caragheorgheopol A, Horhoianu V. Sertoli-Leydig cell tumor e a rare androgen secreting ovarian tumor in postmenopausal women Case report and review of literature. J Cell Mol Med 2003; 7: 461-71.
  • 10. Chen L, Tunnell CD, Petris GD. Sertoli-Leydig cell tumor with heterologous element: a case report and a review of the literature. Int J Clin Exp Pathol 2014; 7(3): 1176- 1181.
  • 11. Guo L, Yang X, Zhu H, Qiu W, Shi X, Huang B, Duan T. SertolieLeydig cell tumor presenting hyperestrogenism in a postmenopausal woman: A case report and review of the literature. Taiwanese Journal of Obstetrics & Gynecology 2012; 51: 620-624.
  • 12. Gui T, Cao D, Shen K, Yang J, Zhang Y, Yu Q, Wan X, Xiang Y, Xiao Y, Guo L. A clinicopatholo gical analysis of 40 cases of ovarian Sertoli-Leydig cell tumors. Gynecol Oncol 2012; 127: 384-389.
  • 13. Sigismondi C, Gadducci A, Lorusso D, Candiani M, Breda E, Raspagliesi, et al. Ovarian Sertoli–Leydig cell tumors. A retrospective MITO study. Gynecol Oncol 2012; 125(3): 673-6.
There are 13 citations in total.

Details

Other ID JA73GP49NE
Journal Section Case Report
Authors

Meryem Eken This is me

Doğukan Arığın This is me

Ecmel Kaygusuz This is me

Mesut Polat This is me

Ateş Karateke This is me

Publication Date July 1, 2014
Submission Date July 1, 2014
Published in Issue Year 2014 Volume: 17 Issue: 3

Cite

APA Eken, M., Arığın, D., Kaygusuz, E., Polat, M., et al. (2014). SERTOLİ LEYDİG HÜCRELİ TÜMÖR: 4 OLGU SUNUMU VE LİTERATÜRÜN GÖZDEN GEÇİRİLMESİ. Türk Jinekolojik Onkoloji Dergisi, 17(3).
AMA Eken M, Arığın D, Kaygusuz E, Polat M, Karateke A. SERTOLİ LEYDİG HÜCRELİ TÜMÖR: 4 OLGU SUNUMU VE LİTERATÜRÜN GÖZDEN GEÇİRİLMESİ. TRSGO Dergisi. July 2014;17(3).
Chicago Eken, Meryem, Doğukan Arığın, Ecmel Kaygusuz, Mesut Polat, and Ateş Karateke. “SERTOLİ LEYDİG HÜCRELİ TÜMÖR: 4 OLGU SUNUMU VE LİTERATÜRÜN GÖZDEN GEÇİRİLMESİ”. Türk Jinekolojik Onkoloji Dergisi 17, no. 3 (July 2014).
EndNote Eken M, Arığın D, Kaygusuz E, Polat M, Karateke A (July 1, 2014) SERTOLİ LEYDİG HÜCRELİ TÜMÖR: 4 OLGU SUNUMU VE LİTERATÜRÜN GÖZDEN GEÇİRİLMESİ. Türk Jinekolojik Onkoloji Dergisi 17 3
IEEE M. Eken, D. Arığın, E. Kaygusuz, M. Polat, and A. Karateke, “SERTOLİ LEYDİG HÜCRELİ TÜMÖR: 4 OLGU SUNUMU VE LİTERATÜRÜN GÖZDEN GEÇİRİLMESİ”, TRSGO Dergisi, vol. 17, no. 3, 2014.
ISNAD Eken, Meryem et al. “SERTOLİ LEYDİG HÜCRELİ TÜMÖR: 4 OLGU SUNUMU VE LİTERATÜRÜN GÖZDEN GEÇİRİLMESİ”. Türk Jinekolojik Onkoloji Dergisi 17/3 (July 2014).
JAMA Eken M, Arığın D, Kaygusuz E, Polat M, Karateke A. SERTOLİ LEYDİG HÜCRELİ TÜMÖR: 4 OLGU SUNUMU VE LİTERATÜRÜN GÖZDEN GEÇİRİLMESİ. TRSGO Dergisi. 2014;17.
MLA Eken, Meryem et al. “SERTOLİ LEYDİG HÜCRELİ TÜMÖR: 4 OLGU SUNUMU VE LİTERATÜRÜN GÖZDEN GEÇİRİLMESİ”. Türk Jinekolojik Onkoloji Dergisi, vol. 17, no. 3, 2014.
Vancouver Eken M, Arığın D, Kaygusuz E, Polat M, Karateke A. SERTOLİ LEYDİG HÜCRELİ TÜMÖR: 4 OLGU SUNUMU VE LİTERATÜRÜN GÖZDEN GEÇİRİLMESİ. TRSGO Dergisi. 2014;17(3).