Hamlet and Bamlet

Year 2017, Volume: 20 Issue: 2, 1 - 6, 08.03.2019

İzzet Ülker , Gamze Akbulut

Abstract

HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a compound that allows the cancer cell to die by forming a
complex of oleic acid with lactoalbumin derived from human milk. BAMLET (Bovine Alpha-lactalbumin Made LEthal to Tumor
cells) is a compound that causes the cancer cell to form oleic acid with lactoalbumin, which is obtained from the milk of bovine
animals. Both compounds can form in the stomach as well as in vitro conditions. Tumor cells may undergo cell death in a variety
of ways, including apoptosis, necrosis, and autophagic. The eff ects of both compounds on cancer cells are similar to apoptosis.
Despite the fact that both animal and human studies are conducted with both compounds in the literature, they are a treatment
method which is still in research stage.

Keywords

Hamlet, Bamlet, Apoptosis

Hamlet and Bamlet

Abstract

HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) insan sütünden elde edilen laktoalbumin ile oleik asidin
kompleks oluşturarak kanser hücresinin ölmesini sağlayan bileşiktir. BAMLET (Bovine Alpha-lactalbumin Made LEthal to Tumor
cells) ise büyükbaş hayvanların sütünden elde edilen laktoalbumin ile oleik asidin bileşik oluşturması ile kanser hücresine
sebep olan bileşiktir. Her iki bileşik de in vitro koşullarda oluşabildiği gibi, mide de oluşabilmektedir. Tümör hücreleri apoptoz,
nekroz, otofajik gibi çeşitli yollarla hücre ölümlerine uğrayabilir. Her iki bileşiğin de kanser hücreleri üzerine etkileri apoptoza
benzetilmektedir. Literatürde her iki bileşikle yapılmış hayvan ve insan çalışmaları olmakla birlikte henüz araştırma aşamasında
olan bir tedavi yöntemidir.

Keywords

Hamlet, Bamlet, Apoptoz

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