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Hamlet and Bamlet

Year 2017, Volume: 20 Issue: 2, 1 - 6, 08.03.2019

Abstract

HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a compound that allows the cancer cell to die by forming a
complex of oleic acid with lactoalbumin derived from human milk. BAMLET (Bovine Alpha-lactalbumin Made LEthal to Tumor
cells) is a compound that causes the cancer cell to form oleic acid with lactoalbumin, which is obtained from the milk of bovine
animals. Both compounds can form in the stomach as well as in vitro conditions. Tumor cells may undergo cell death in a variety
of ways, including apoptosis, necrosis, and autophagic. The eff ects of both compounds on cancer cells are similar to apoptosis.
Despite the fact that both animal and human studies are conducted with both compounds in the literature, they are a treatment
method which is still in research stage.

References

  • 1. Svensson M, Hakansson A, Mossberg AK, Linse SSvanborg C. Conversion of alpha-lactalbumin to a protein inducing apoptosis. Proc Natl Acad Sci U S A, 2000;97:(8): 4221-6.
  • 2. Hakansson A, Zhivotovsky B, Orrenius S, Sabharwal HSvanborg C. Apoptosis induced by a human milk protein. Proc Natl Acad Sci U S A, 1995;92:(17): 8064-8.
  • 3. Fang B, Zhang M, Tian M, Jiang L, Guo HYRen FZ. Bovine lactoferrin binds oleic acid to form an anti-tumor complex similar to HAMLET. Biochim Biophys Acta, 2014;1841:(4): 535-43.
  • 4. Rath EM, Duff AP, Hakansson AP, Vacher CS, Liu GJ, Knott RBChurch WB. Structure and Potential Cellular Targets of HAMLET-like Anti-Cancer Compounds made from Milk Components. J Pharm Pharm Sci, 2015;18:(4): 773-824.
  • 5. Mok KH, Pettersson J, Orrenius SSvanborg C. HAMLET, protein folding, and tumor cell death. Biochem Biophys Res Commun, 2007;354:(1): 1-7.
  • 6. Permyakov EABerliner LJ. alpha-Lactalbumin: structure and function. FEBS Lett, 2000;473:(3): 269-74.
  • 7. Ho JC, Nadeem ASvanborg C. HAMLET - A protein-lipid complex with broad tumoricidal activity. Biochem Biophys Res Commun, 2017;482:(3): 454-458.
  • 8. Kaufman RJ. Orchestrating the unfolded protein response in health and disease. J Clin Invest, 2002;110:(10): 1389-98.
  • 9. Hallgren O, Gustafsson L, Irjala H, Selivanova G, Orrenius SSvanborg C. HAMLET triggers apoptosis but tumor cell death is independent of caspases, Bcl-2 and p53. Apoptosis, 2006;11:(2): 221-33.
  • 10. Ciechanover A. Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. Best Pract Res Clin Haematol, 2017;30:(4): 341- 355.
  • 11. Goldberg AL. Protein degradation and protection against misfolded or damaged proteins. Nature, 2003;426:(6968): 895-9.
  • 12. Duringer C, Hamiche A, Gustafsson L, Kimura HSvanborg C. HAMLET interacts with histones and chromatin in tumor cell nuclei. J Biol Chem, 2003;278:(43): 42131-5.
  • 13. Yorimitsu TKlionsky DJ. Autophagy: molecular machinery for self-eating. Cell Death Differ, 2005;12 Suppl 2: 1542-52.
  • 14. Mizushima N, Ohsumi YYoshimori T. Autophagosome formation in mammalian cells. Cell Struct Funct, 2002;27:(6): 421-9.
  • 15. Codogno PMeijer AJ. Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ, 2005;12 Suppl 2: 1509-18.
  • 16. Deretic V. Autophagy as an immune defense mechanism. Curr Opin Immunol, 2006;18:(4): 375-82.
  • 17. Baehrecke EH. Autophagy: dual roles in life and death? Nat Rev Mol Cell Biol, 2005;6:(6): 505-10.
  • 18. Debnath J, Baehrecke EHKroemer G. Does autophagy contribute to cell death? Autophagy, 2005;1:(2): 66-74.
  • 19. Ho J, Sielaff H, Nadeem A, Svanborg CGruber G. The molecular motor F-ATP synthase is targeted by the tumoricidal protein HAMLET. J Mol Biol, 2015;427:(10): 1866-74.
  • 20. Gustafsson L, Aits S, Onnerfjord P, Trulsson M, Storm PSvanborg C. Changes in proteasome structure and function caused by HAMLET in tumor cells. PLoS One, 2009;4:(4): e5229.
  • 21. Mossberg AK, Hou Y, Svensson M, Holmqvist BSvanborg C. HAMLET treatment delays bladder cancer development. J Urol, 2010;183:(4): 1590-7.
  • 22. Fischer W, Gustafsson L, Mossberg AK, Gronli J, Mork S, Bjerkvig RSvanborg C. Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival. Cancer Res, 2004;64:(6): 2105-12.
  • 23. Puthia M, Storm P, Nadeem A, Hsiung SSvanborg C. Prevention and treatment of colon cancer by peroral administration of HAMLET (human alpha-lactalbumin made lethal to tumour cells). Gut, 2014;63:(1): 131-42.
  • 24. Mossberg AK, Wullt B, Gustafsson L, Mansson W, Ljunggren ESvanborg C. Bladder cancers respond to intravesical instillation of HAMLET (human alpha-lactalbumin made lethal to tumor cells). Int J Cancer, 2007;121:(6): 1352-9.
  • 25. Gustafsson L, Leijonhufvud I, Aronsson A, Mossberg AKSvanborg C. Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid. N Engl J Med, 2004;350:(26): 2663-72.
  • 26. Artym JZimecki M. Milk-derived proteins and peptides in clinical trials. Postepy Hig Med Dosw (Online), 2013;67: 800-16.
  • 27. Rammer P, Groth-Pedersen L, Kirkegaard T, Daugaard M, Rytter A, Szyniarowski P, Hoyer-Hansen M, Povlsen LK, Nylandsted J, Larsen JEJaattela M. BAMLET activates a lysosomal cell death program in cancer cells. Mol Cancer Ther, 2010;9:(1): 24-32.

Hamlet and Bamlet

Year 2017, Volume: 20 Issue: 2, 1 - 6, 08.03.2019

Abstract

HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) insan sütünden elde edilen laktoalbumin ile oleik asidin
kompleks oluşturarak kanser hücresinin ölmesini sağlayan bileşiktir. BAMLET (Bovine Alpha-lactalbumin Made LEthal to Tumor
cells) ise büyükbaş hayvanların sütünden elde edilen laktoalbumin ile oleik asidin bileşik oluşturması ile kanser hücresine
sebep olan bileşiktir. Her iki bileşik de in vitro koşullarda oluşabildiği gibi, mide de oluşabilmektedir. Tümör hücreleri apoptoz,
nekroz, otofajik gibi çeşitli yollarla hücre ölümlerine uğrayabilir. Her iki bileşiğin de kanser hücreleri üzerine etkileri apoptoza
benzetilmektedir. Literatürde her iki bileşikle yapılmış hayvan ve insan çalışmaları olmakla birlikte henüz araştırma aşamasında
olan bir tedavi yöntemidir.

References

  • 1. Svensson M, Hakansson A, Mossberg AK, Linse SSvanborg C. Conversion of alpha-lactalbumin to a protein inducing apoptosis. Proc Natl Acad Sci U S A, 2000;97:(8): 4221-6.
  • 2. Hakansson A, Zhivotovsky B, Orrenius S, Sabharwal HSvanborg C. Apoptosis induced by a human milk protein. Proc Natl Acad Sci U S A, 1995;92:(17): 8064-8.
  • 3. Fang B, Zhang M, Tian M, Jiang L, Guo HYRen FZ. Bovine lactoferrin binds oleic acid to form an anti-tumor complex similar to HAMLET. Biochim Biophys Acta, 2014;1841:(4): 535-43.
  • 4. Rath EM, Duff AP, Hakansson AP, Vacher CS, Liu GJ, Knott RBChurch WB. Structure and Potential Cellular Targets of HAMLET-like Anti-Cancer Compounds made from Milk Components. J Pharm Pharm Sci, 2015;18:(4): 773-824.
  • 5. Mok KH, Pettersson J, Orrenius SSvanborg C. HAMLET, protein folding, and tumor cell death. Biochem Biophys Res Commun, 2007;354:(1): 1-7.
  • 6. Permyakov EABerliner LJ. alpha-Lactalbumin: structure and function. FEBS Lett, 2000;473:(3): 269-74.
  • 7. Ho JC, Nadeem ASvanborg C. HAMLET - A protein-lipid complex with broad tumoricidal activity. Biochem Biophys Res Commun, 2017;482:(3): 454-458.
  • 8. Kaufman RJ. Orchestrating the unfolded protein response in health and disease. J Clin Invest, 2002;110:(10): 1389-98.
  • 9. Hallgren O, Gustafsson L, Irjala H, Selivanova G, Orrenius SSvanborg C. HAMLET triggers apoptosis but tumor cell death is independent of caspases, Bcl-2 and p53. Apoptosis, 2006;11:(2): 221-33.
  • 10. Ciechanover A. Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. Best Pract Res Clin Haematol, 2017;30:(4): 341- 355.
  • 11. Goldberg AL. Protein degradation and protection against misfolded or damaged proteins. Nature, 2003;426:(6968): 895-9.
  • 12. Duringer C, Hamiche A, Gustafsson L, Kimura HSvanborg C. HAMLET interacts with histones and chromatin in tumor cell nuclei. J Biol Chem, 2003;278:(43): 42131-5.
  • 13. Yorimitsu TKlionsky DJ. Autophagy: molecular machinery for self-eating. Cell Death Differ, 2005;12 Suppl 2: 1542-52.
  • 14. Mizushima N, Ohsumi YYoshimori T. Autophagosome formation in mammalian cells. Cell Struct Funct, 2002;27:(6): 421-9.
  • 15. Codogno PMeijer AJ. Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ, 2005;12 Suppl 2: 1509-18.
  • 16. Deretic V. Autophagy as an immune defense mechanism. Curr Opin Immunol, 2006;18:(4): 375-82.
  • 17. Baehrecke EH. Autophagy: dual roles in life and death? Nat Rev Mol Cell Biol, 2005;6:(6): 505-10.
  • 18. Debnath J, Baehrecke EHKroemer G. Does autophagy contribute to cell death? Autophagy, 2005;1:(2): 66-74.
  • 19. Ho J, Sielaff H, Nadeem A, Svanborg CGruber G. The molecular motor F-ATP synthase is targeted by the tumoricidal protein HAMLET. J Mol Biol, 2015;427:(10): 1866-74.
  • 20. Gustafsson L, Aits S, Onnerfjord P, Trulsson M, Storm PSvanborg C. Changes in proteasome structure and function caused by HAMLET in tumor cells. PLoS One, 2009;4:(4): e5229.
  • 21. Mossberg AK, Hou Y, Svensson M, Holmqvist BSvanborg C. HAMLET treatment delays bladder cancer development. J Urol, 2010;183:(4): 1590-7.
  • 22. Fischer W, Gustafsson L, Mossberg AK, Gronli J, Mork S, Bjerkvig RSvanborg C. Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival. Cancer Res, 2004;64:(6): 2105-12.
  • 23. Puthia M, Storm P, Nadeem A, Hsiung SSvanborg C. Prevention and treatment of colon cancer by peroral administration of HAMLET (human alpha-lactalbumin made lethal to tumour cells). Gut, 2014;63:(1): 131-42.
  • 24. Mossberg AK, Wullt B, Gustafsson L, Mansson W, Ljunggren ESvanborg C. Bladder cancers respond to intravesical instillation of HAMLET (human alpha-lactalbumin made lethal to tumor cells). Int J Cancer, 2007;121:(6): 1352-9.
  • 25. Gustafsson L, Leijonhufvud I, Aronsson A, Mossberg AKSvanborg C. Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid. N Engl J Med, 2004;350:(26): 2663-72.
  • 26. Artym JZimecki M. Milk-derived proteins and peptides in clinical trials. Postepy Hig Med Dosw (Online), 2013;67: 800-16.
  • 27. Rammer P, Groth-Pedersen L, Kirkegaard T, Daugaard M, Rytter A, Szyniarowski P, Hoyer-Hansen M, Povlsen LK, Nylandsted J, Larsen JEJaattela M. BAMLET activates a lysosomal cell death program in cancer cells. Mol Cancer Ther, 2010;9:(1): 24-32.
There are 27 citations in total.

Details

Primary Language Turkish
Subjects Surgery
Journal Section Collection
Authors

İzzet Ülker

Gamze Akbulut This is me

Publication Date March 8, 2019
Submission Date August 9, 2018
Published in Issue Year 2017 Volume: 20 Issue: 2

Cite

APA Ülker, İ., & Akbulut, G. (2019). Hamlet and Bamlet. Türk Jinekolojik Onkoloji Dergisi, 20(2), 1-6.
AMA Ülker İ, Akbulut G. Hamlet and Bamlet. TRSGO Dergisi. March 2019;20(2):1-6.
Chicago Ülker, İzzet, and Gamze Akbulut. “Hamlet and Bamlet”. Türk Jinekolojik Onkoloji Dergisi 20, no. 2 (March 2019): 1-6.
EndNote Ülker İ, Akbulut G (March 1, 2019) Hamlet and Bamlet. Türk Jinekolojik Onkoloji Dergisi 20 2 1–6.
IEEE İ. Ülker and G. Akbulut, “Hamlet and Bamlet”, TRSGO Dergisi, vol. 20, no. 2, pp. 1–6, 2019.
ISNAD Ülker, İzzet - Akbulut, Gamze. “Hamlet and Bamlet”. Türk Jinekolojik Onkoloji Dergisi 20/2 (March 2019), 1-6.
JAMA Ülker İ, Akbulut G. Hamlet and Bamlet. TRSGO Dergisi. 2019;20:1–6.
MLA Ülker, İzzet and Gamze Akbulut. “Hamlet and Bamlet”. Türk Jinekolojik Onkoloji Dergisi, vol. 20, no. 2, 2019, pp. 1-6.
Vancouver Ülker İ, Akbulut G. Hamlet and Bamlet. TRSGO Dergisi. 2019;20(2):1-6.