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Infiltrative Type Mucinous Ovarian Cancer Diagnosed Durıng Pregnancy A Case Report And Literature Review

Year 2025, Volume: 25 Issue: 1, 10 - 17, 02.06.2025

Abstract

The incidence of ovarian malignancies during pregnancy is rare and is estimated to be approximately 1:10,000 to 1:50,000 in pregnant women. In this case report, we present a rare case of infiltrative type mucinous ovarian cancer in pregnancy. A 38-year-old patient, who was referred to our clinic with the diagnosis of adnexal mass in the 12th gestational week, underwent right oophorectomy and was diagnosed with infiltrative mucinous ovarian cancer on pathology, was offered an individual treatment plan considering the available literature and her own expectations. Termination of pregnancy and cytoreductive surgery were recommended to the patient.

References

  • Mukhopadhyay A, Shinde A, Naik R. Ovarian cysts and cancer in pregnancy. Best Pract Res Clin Obstet Gynaecol. 2016;33:58-72.
  • Mancari R, Tomasi-Cont N, Sarno MA, et al. Treatment options for pregnant women with ovarian tumors. Int J Gynecol Cancer. 2014;24(6):967-972.
  • Palmer J, Jivraj S, Galimberti A, Paterson M. Serous ovarian carcinoma in pregnancy. BMJ Case Rep. 2009;2009.
  • Xu T, Wang L, Jia Y, et al. Long-term multidisciplinary integrative therapy management resulted in favorable outcomes for ovarian cancer during pregnancy: a case report and literature review. J Ovarian Res. 2019;12(1).
  • Amant F, Berveiller P, Boere IA, et al. Gynecologic cancers in pregnancy: guidelines based on a third international con-sensus meeting. Annals of Oncology. 2019;30(10):1601-1612.
  • Cathcart AM, Nezhat FR, Emerson J, Pejovic T, Nezhat CH, Nezhat CR. Adnexal masses during pregnancy: diagnosis, treatment, and prognosis. Am J Obstet Gynecol. 2023;228(6):601-612.
  • Aslam N, Ong C, Woelfer B, Nicolaides K, Jurkovic D. Serum CA125 at 11–14 weeks of gestation in women with morp-hologically normal ovaries. BJOG. 2000;107(5):689-690.
  • Ellenson LH, Carinelli S, Kim KR, et al. WHO Classification of Tumours of Female Reproductive Organs. (Kurman RJ, Car-cangiu M, Young RH, eds.). IARC; 2014.
  • Hada T, Miyamoto M, Ohtsuka Y, et al. Genetic analysis for mucinous ovarian carcinoma with infiltrative and expansile invasion and mucinous borderline tumor: a retrospective analysis. Diagn Pathol. 2023;18(1):49.
  • Muyldermans K, Moerman P, Amant F, Leunen K, Neven P, Vergote I. Primary invasive mucinous ovarian carcinoma of the intestinal type: importance of the expansile versus infiltrative type in predicting recurrence and lymph node metas-tases. Eur J Cancer. 2013;49(7):1600-1608.
  • Rodríguez IM, Prat J. Mucinous tumors of the ovary: a clinicopathologic analysis of 75 borderline tumors (of intestinal type) and carcinomas. Am J Surg Pathol. 2002;26(2):139-152.
  • Seidman JD, Horkayne-Szakaly I, Haiba M, Boice CR, Kurman RJ, Ronnett BM. The histologic type and stage distribution of ovarian carcinomas of surface epithelial origin. Int J Gynecol Pathol. 2004;23(1):41-44.
  • Babaier A, Ghatage P. Mucinous Cancer of the Ovary: Overview and Current Status. Diagnostics. 2020;10(1).
  • Nasioudis D, Haggerty AF, Giuntoli RL, et al. Adjuvant chemotherapy is not associated with a survival benefit for pati-ents with early stage mucinous ovarian carcinoma. Gynecol Oncol. 2019;154(2):302-307.
  • Morice P, Gouy S, Leary A. Mucinous Ovarian Carcinoma. New England Journal of Medicine. 2019;380(13):1256-1266.
  • Simons M, Massuger L, Bruls J, Bulten J, Teerenstra S, Nagtegaal I. Relatively Poor Survival of Mucinous Ovarian Carci-noma in Advanced Stage: A Systematic Review and Meta-analysis. Int J Gynecol Cancer. 2017;27(4):651-658.
  • Borella F, Mitidieri M, Cosma S, et al. Update on Prognostic and Predictive Markers in Mucinous Ovarian Cancer. Can-cers (Basel). 2023;15(4).
  • Kurnit KC, Sinno AK, Fellman B, et al. Gastrointestinal adjuvant chemotherapy regimens improve survival outcomes in women with mucinous ovarian cancer. Gynecol Oncol. 2019;154:248-249.
  • Gore M, Hackshaw A, Brady WE, et al. An international, phase III randomized trial in patients with mucinous epithelial ovarian cancer (mEOC/GOG 0241) with long-term follow-up: and experience of conducting a clinical trial in a rare gyne-cological tumor. Gynecol Oncol. 2019;153(3):541.
  • Gouy S, Saidani M, Maulard A, et al. Characteristics and Prognosis of Stage I Ovarian Mucinous Tumors According to Expansile or Infiltrative Type. Int J Gynecol Cancer. 2018;28(3):493-499.
  • Esposito S, Tenconi R, Preti V, Groppali E, Principi N. Chemotherapy against cancer during pregnancy: A systematic re-view on neonatal outcomes. Medicine. 2016;95(38).
  • Korenaga TRK, Tewari KS. Gynecologic Cancer in Pregnancy. Gynecol Oncol. 2020;157(3):799.
  • Abdel-Hady ES, Hemida RAH, Gamal A, El-Zafarany M, Toson E, El-Bayoumi MA. Cancer during pregnancy: perinatal outcome after in utero exposure to chemotherapy. Arch Gynecol Obstet. 2012;286(2):283-286.
  • Hase EA, Shinohara HN, Alves Filho JAG, Sadalla JC, Ab́saber AM, Francisco RPV. Primary intestinal type mucinous ade-nocarcinoma of the ovary diagnosed during pregnancy – Maternal and neonatal treatment and outcomes: A case re-port. Front Med (Lausanne). 2023;10:1138447.
  • Bouab M, Elazzouzi E, El Miski F, et al. Rare association of the ovarian adenocarcinoma with pregnancy: A case report. Annals of Medicine and Surgery. 2022;75:103350.
  • He SY, Shen HW, Xu L, Li XL, Yao SZ. Successful management of mucinous ovarian cancer by conservative surgery in week 6 of pregnancy: case report and literature review. Arch Gynecol Obstet. 2012;286(4):989.

Gebelikte Teşhis Edilen İnfiltratif Tip Müsinöz Tip Yumurtalık Kanseri, Vaka Raporu Ve Litertür Derlemesi

Year 2025, Volume: 25 Issue: 1, 10 - 17, 02.06.2025

Abstract

Gebelik sırasında yumurtalık malignitelerinin görülmesi nadirdir ve gebe kadınlarda yaklaşık 1:10.000 ila 1:50.000 oranında görüldüğü tahmin edilmektedir. Bu olgu sunumunda literatürde ender görülen gebelikte saptağımız infiltratif tip müsinöz over kanseri olgusunu sunuyoruz. 38 yaşında, 12. gebelik haftasında adneksiyal kitle tanısıyla kliniğimize sevk edilen, sağ ooferektomi uygulanan ve patoloji sonucunda infiltratif tip müsinöz over kanseri teşhisi konulan hastaya mevcut literatür ve kendi beklentileri dikkate alınarak bireysel tedavi planı sunuldu. Hastaya gebeliğinin sonlandırılması ve sitoredüktif cerrahi yapılması önerildi.

References

  • Mukhopadhyay A, Shinde A, Naik R. Ovarian cysts and cancer in pregnancy. Best Pract Res Clin Obstet Gynaecol. 2016;33:58-72.
  • Mancari R, Tomasi-Cont N, Sarno MA, et al. Treatment options for pregnant women with ovarian tumors. Int J Gynecol Cancer. 2014;24(6):967-972.
  • Palmer J, Jivraj S, Galimberti A, Paterson M. Serous ovarian carcinoma in pregnancy. BMJ Case Rep. 2009;2009.
  • Xu T, Wang L, Jia Y, et al. Long-term multidisciplinary integrative therapy management resulted in favorable outcomes for ovarian cancer during pregnancy: a case report and literature review. J Ovarian Res. 2019;12(1).
  • Amant F, Berveiller P, Boere IA, et al. Gynecologic cancers in pregnancy: guidelines based on a third international con-sensus meeting. Annals of Oncology. 2019;30(10):1601-1612.
  • Cathcart AM, Nezhat FR, Emerson J, Pejovic T, Nezhat CH, Nezhat CR. Adnexal masses during pregnancy: diagnosis, treatment, and prognosis. Am J Obstet Gynecol. 2023;228(6):601-612.
  • Aslam N, Ong C, Woelfer B, Nicolaides K, Jurkovic D. Serum CA125 at 11–14 weeks of gestation in women with morp-hologically normal ovaries. BJOG. 2000;107(5):689-690.
  • Ellenson LH, Carinelli S, Kim KR, et al. WHO Classification of Tumours of Female Reproductive Organs. (Kurman RJ, Car-cangiu M, Young RH, eds.). IARC; 2014.
  • Hada T, Miyamoto M, Ohtsuka Y, et al. Genetic analysis for mucinous ovarian carcinoma with infiltrative and expansile invasion and mucinous borderline tumor: a retrospective analysis. Diagn Pathol. 2023;18(1):49.
  • Muyldermans K, Moerman P, Amant F, Leunen K, Neven P, Vergote I. Primary invasive mucinous ovarian carcinoma of the intestinal type: importance of the expansile versus infiltrative type in predicting recurrence and lymph node metas-tases. Eur J Cancer. 2013;49(7):1600-1608.
  • Rodríguez IM, Prat J. Mucinous tumors of the ovary: a clinicopathologic analysis of 75 borderline tumors (of intestinal type) and carcinomas. Am J Surg Pathol. 2002;26(2):139-152.
  • Seidman JD, Horkayne-Szakaly I, Haiba M, Boice CR, Kurman RJ, Ronnett BM. The histologic type and stage distribution of ovarian carcinomas of surface epithelial origin. Int J Gynecol Pathol. 2004;23(1):41-44.
  • Babaier A, Ghatage P. Mucinous Cancer of the Ovary: Overview and Current Status. Diagnostics. 2020;10(1).
  • Nasioudis D, Haggerty AF, Giuntoli RL, et al. Adjuvant chemotherapy is not associated with a survival benefit for pati-ents with early stage mucinous ovarian carcinoma. Gynecol Oncol. 2019;154(2):302-307.
  • Morice P, Gouy S, Leary A. Mucinous Ovarian Carcinoma. New England Journal of Medicine. 2019;380(13):1256-1266.
  • Simons M, Massuger L, Bruls J, Bulten J, Teerenstra S, Nagtegaal I. Relatively Poor Survival of Mucinous Ovarian Carci-noma in Advanced Stage: A Systematic Review and Meta-analysis. Int J Gynecol Cancer. 2017;27(4):651-658.
  • Borella F, Mitidieri M, Cosma S, et al. Update on Prognostic and Predictive Markers in Mucinous Ovarian Cancer. Can-cers (Basel). 2023;15(4).
  • Kurnit KC, Sinno AK, Fellman B, et al. Gastrointestinal adjuvant chemotherapy regimens improve survival outcomes in women with mucinous ovarian cancer. Gynecol Oncol. 2019;154:248-249.
  • Gore M, Hackshaw A, Brady WE, et al. An international, phase III randomized trial in patients with mucinous epithelial ovarian cancer (mEOC/GOG 0241) with long-term follow-up: and experience of conducting a clinical trial in a rare gyne-cological tumor. Gynecol Oncol. 2019;153(3):541.
  • Gouy S, Saidani M, Maulard A, et al. Characteristics and Prognosis of Stage I Ovarian Mucinous Tumors According to Expansile or Infiltrative Type. Int J Gynecol Cancer. 2018;28(3):493-499.
  • Esposito S, Tenconi R, Preti V, Groppali E, Principi N. Chemotherapy against cancer during pregnancy: A systematic re-view on neonatal outcomes. Medicine. 2016;95(38).
  • Korenaga TRK, Tewari KS. Gynecologic Cancer in Pregnancy. Gynecol Oncol. 2020;157(3):799.
  • Abdel-Hady ES, Hemida RAH, Gamal A, El-Zafarany M, Toson E, El-Bayoumi MA. Cancer during pregnancy: perinatal outcome after in utero exposure to chemotherapy. Arch Gynecol Obstet. 2012;286(2):283-286.
  • Hase EA, Shinohara HN, Alves Filho JAG, Sadalla JC, Ab́saber AM, Francisco RPV. Primary intestinal type mucinous ade-nocarcinoma of the ovary diagnosed during pregnancy – Maternal and neonatal treatment and outcomes: A case re-port. Front Med (Lausanne). 2023;10:1138447.
  • Bouab M, Elazzouzi E, El Miski F, et al. Rare association of the ovarian adenocarcinoma with pregnancy: A case report. Annals of Medicine and Surgery. 2022;75:103350.
  • He SY, Shen HW, Xu L, Li XL, Yao SZ. Successful management of mucinous ovarian cancer by conservative surgery in week 6 of pregnancy: case report and literature review. Arch Gynecol Obstet. 2012;286(4):989.
There are 26 citations in total.

Details

Primary Language English
Subjects Gynecologic Oncology Surgery
Journal Section Collection
Authors

Celal Akdemir 0000-0002-4070-7583

Ali Onur Arzık 0000-0002-5878-0391

Zeliha Öcal 0009-0000-7094-8911

İlayda Gercik Arzık 0000-0001-7308-352X

Şimal Çoban 0000-0001-6398-9694

Özlem Özdemir 0000-0003-2520-5953

Ayhan Gül 0000-0003-3681-8712

Muzaffer Sancı 0000-0002-8494-4302

Early Pub Date May 1, 2025
Publication Date June 2, 2025
Submission Date November 15, 2024
Acceptance Date April 29, 2025
Published in Issue Year 2025 Volume: 25 Issue: 1

Cite

APA Akdemir, C., Arzık, A. O., Öcal, Z., Gercik Arzık, İ., et al. (2025). Infiltrative Type Mucinous Ovarian Cancer Diagnosed Durıng Pregnancy A Case Report And Literature Review. Türk Jinekolojik Onkoloji Dergisi, 25(1), 10-17.
AMA Akdemir C, Arzık AO, Öcal Z, Gercik Arzık İ, Çoban Ş, Özdemir Ö, Gül A, Sancı M. Infiltrative Type Mucinous Ovarian Cancer Diagnosed Durıng Pregnancy A Case Report And Literature Review. TRSGO Dergisi. June 2025;25(1):10-17.
Chicago Akdemir, Celal, Ali Onur Arzık, Zeliha Öcal, İlayda Gercik Arzık, Şimal Çoban, Özlem Özdemir, Ayhan Gül, and Muzaffer Sancı. “Infiltrative Type Mucinous Ovarian Cancer Diagnosed Durıng Pregnancy A Case Report And Literature Review”. Türk Jinekolojik Onkoloji Dergisi 25, no. 1 (June 2025): 10-17.
EndNote Akdemir C, Arzık AO, Öcal Z, Gercik Arzık İ, Çoban Ş, Özdemir Ö, Gül A, Sancı M (June 1, 2025) Infiltrative Type Mucinous Ovarian Cancer Diagnosed Durıng Pregnancy A Case Report And Literature Review. Türk Jinekolojik Onkoloji Dergisi 25 1 10–17.
IEEE C. Akdemir, A. O. Arzık, Z. Öcal, İ. Gercik Arzık, Ş. Çoban, Ö. Özdemir, A. Gül, and M. Sancı, “Infiltrative Type Mucinous Ovarian Cancer Diagnosed Durıng Pregnancy A Case Report And Literature Review”, TRSGO Dergisi, vol. 25, no. 1, pp. 10–17, 2025.
ISNAD Akdemir, Celal et al. “Infiltrative Type Mucinous Ovarian Cancer Diagnosed Durıng Pregnancy A Case Report And Literature Review”. Türk Jinekolojik Onkoloji Dergisi 25/1 (June 2025), 10-17.
JAMA Akdemir C, Arzık AO, Öcal Z, Gercik Arzık İ, Çoban Ş, Özdemir Ö, Gül A, Sancı M. Infiltrative Type Mucinous Ovarian Cancer Diagnosed Durıng Pregnancy A Case Report And Literature Review. TRSGO Dergisi. 2025;25:10–17.
MLA Akdemir, Celal et al. “Infiltrative Type Mucinous Ovarian Cancer Diagnosed Durıng Pregnancy A Case Report And Literature Review”. Türk Jinekolojik Onkoloji Dergisi, vol. 25, no. 1, 2025, pp. 10-17.
Vancouver Akdemir C, Arzık AO, Öcal Z, Gercik Arzık İ, Çoban Ş, Özdemir Ö, Gül A, Sancı M. Infiltrative Type Mucinous Ovarian Cancer Diagnosed Durıng Pregnancy A Case Report And Literature Review. TRSGO Dergisi. 2025;25(1):10-7.