Evaluation of Ganglion Cell-Inner Plexiform and Retinal Nerve Fiber Layer Thicknesses in Obese Children and Their Associations with Obesity Severity and Duration

Abstract

Aim: To evaluate the macular ganglion cell-inner plexiform layer (GC-IPL) and the retinal nerve fiber layer (RNFL) thicknesses measured by high-definition optical coherence tomography (HD-OCT) in children with obesity and to determine whether thickness parameters are correlated to disease severity and duration.

Materials and Methods: This prospective study involved 40 obese and 40 age and sex-matched non-obese children aged between 6 and 17 years. Following the measurement of body mass index (BMI), cycloplegic auto-refraction, intraocular pressure, and axial length (AL) was measured. OCT scans were performed using Cirrus HD-OCT (Carl-Zeiss Meditec, Dublin, CA, USA). Right eye of each subject was selected for analysis.

Results: The study included 40 healthy children and 40 children with obesity. The RNFL thickness measurements revealed thinner in the obesity group compared to controls for all quadrants however, the only statistically difference were for the average and superior quadrants (P < 0.05). All GC-IPL thickness parameters were statistically thinner in the obese subjects compared to the controls (P < 0.05). Average peripapillary RNFL and macular GC-IPL thicknesses and some quadrants and sectors are inversely correlated with disease severity and duration.

Conclusions: Macular GC-IPL and peripapillary RNFL thicknesses were significantly lower in obese children than controls and a negative correlation between the severity and duration of obesity and both the GC-IPL and RNFL thicknesses could indicate that obesity control in children may be a crucial strategy for prevention of glaucoma.

Keywords

• GC-IPL and RNFL thicknesses,Obese children

Obez Çocuklarda Ganglion Hücre İç Pleksiform ve Retina Sinir Lifi Tabakası Kalınlıklarının ve Obezite Şiddeti ve Süresi ile Birlikteliğinin Değerlendirilmesi

Abstract

Amaç: Obez çocuklarda maküler gangliyon hücre iç pleksiform tabakası (GH-IPT) ve retina sinir lifi tabakası (RSLT) kalınlıklarının yüksek çözünürlüklü optik koherens tomografi (OKT) ile değerlendirilmesi ve kalınlık parametrelerinin hastalık şiddeti ve süresi ile korele olup olmadığını belirlemek.

Gereç ve Yöntemler: Bu prospektif çalışmaya, 6 ve 17 yaşları arasında 40 obez çocuk ve 40 obez olmayan eşit yaş ve cinsiyette sağlıklı çocuk dahil edildi. Vücut kitle indeksi (VKI) ölçümünü takiben, sikloplejik oto-refraksiyon, göz içi basıncı (GİB) ve aksiyel uzunluk (AU) ölçüldü. OKT taramaları Cirrus HD-OCT (Carl-Zeiss Meditec, Dublin, CA, ABD) kullanılarak yapıldı. Analiz için her bireyin sağ gözü seçilmiştir.

Bulgular: Çalışmaya 40 sağlıklı çocuk ve 40 obez çocuk alındı. RSLT kalınlığı ölçümleri obezite grubunda tüm kadranlar için kontrollere kıyasla daha ince bulundu, ancak istatistiksel olarak tek fark ortalama ve üst kadranlar için idi (P <0.05). Tüm GH-IPT kalınlık parametreleri obez olgularda kontrollere göre istatistiksel olarak daha düşüktü (P <0.05). Ortalama peripapiller RSLT kalınlığı ve maküla GH-IPT kalınlığı, bazı kadranlar ve sektörler hastalık şiddeti ve süresi ile ters orantılıdır.

Sonuç: Maküler GH-IPT ve peripapiller RSLT kalınlıkları obez çocuklarda kontrollere göre anlamlı olarak düşüktü. Hem GH-IPT hem de RSLT kalınlıkları ile obezitenin şiddeti ve süresi arasında negatif bir korelasyon vardı. Çocuklarda glokomun önlenmesi için obezite kontrolünün çok önemli bir strateji olabileceğini düşündürdü.

Keywords

• GH-IPT ve RSLT kalınlıkları,Obez çocuklar

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