Ötiroid Tip 2 Diyabeti Olan Hastalarda HbA1c ve TSH Düzeylerinin Trigliserid Düzeylerine Etkisi
Abstract
Özet
Giriş ve Amaç: Diyabet tüm dünyada ve ülkemizde sıklığı giderek artan bir hastalıktır. Tip 2 Diyabetli hastalarda dislipidemi, koroner arter hastalığının (KAH) gelişiminde önemli yere sahiptir. Hba1c değeri yüksek olan kötü glisemik kontrollü diyabetik hastalarda komplikasyon riski artmış olup dislipidemi taraması ve tedavisi önemlidir. Normal tiroid fonksiyonlarındaki varyasyonların dislipidemi ve kardiyovasküler risk üzerine etkisi net bilinmemektedir . Çalışmamızda ötiroid Tip 2 diyabetes mellitus hastalarında trigliserid (TG) düzeyleri ile HbA1c ve TSH ilişkisini araştırdık.
Yöntem: 19119 diyabet hastasının verileri retrospektif olarak taranarak incelendi. 4908 hasta verileri çalışmaya alınmaya uygun bulundu. HbA1c, TSH, glukoz ve trigliserid (TG) değerleri kaydedildi. TG değerlerine göre 4 gruba ayrılan hastalarda HbA1c ve TSH değerlerinin TG düzeyleri ile ilişkisi araştırılıdı.
Bulgular: HbA1c ve trigliserid düzeyleri arasında pozitif korelasyon, TSH ile negatif korelasyon saptandı.
Sonuç: Özellikle Tip 2 diyabet hastalarında tiroid fonksiyon testleri değerlendirilirken ötiroid olsalar dahi, glisemik regülasyon göstergelerinden A1c düzeyleri ile TSH düzeyleri arasındaki ilişki ve TG düzeylerine etkileri göz önüne alınmalı, A1c değerleri düştükten sonraki seyirleri kontrol edilerek, tedavi ve takip yaklaşımları saptanmalıdır.
Anahtar kelimeler: Tip 2 Diyabetes Mellitus, Trigliserid, TSH, A1c
Summary
HbA1c, TSH and TG relationship in type 2 diabetes
Introduction: The prevalence of diabetes is increasing in our country and all over the world. Dyslipidemia has an important role in the development of coronary artery disease (CAD) in type 2 diabetic patients. The risk of complications is increased in diabetic patients with poor glycemic control and high Hba1c levels. Therefore dyslipidemia screening and treatment is important. The effect of variations in normal thyroid function on dyslipidemia and cardiovascular risk is not clear. So in this study, we investigated the assosiation between HbA1c, TSH and triglyceride (TG) levels in euthyroid type 2 diabetic patients.
Methods: The data of 19119 diabetic patients were retrospectively analyzed. 4908 patients’ data were eligible to be included in the study. HbA1c, TSH, glucose and triglyceride (TG) values were recorded. Patients divided into 4 groups due to TG levels in order to investigate assosiation between hba1c, tsh levels and triglyceride levels in euthyroid, type 2 diabetic patients.
Results: There was a positive correlation between triglyceride and HbA1c levels and negative correlation between triglyceride and TSH levels.
Conclusion: Especially when evaluating thyroid function tests in Type 2 diabetic patients (even if they are euthyroid), the relationship between A1c levels (glycemic control indicator) and TSH levels and their effects on TG levels should be considered. Treatment and follow-up approaches should be determined after A1c values are normalized.
Key Word: Type 2 diabetes Mellitus, tryglyceride, TSH, A1c
Keywords
References
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Details
Primary Language
Turkish
Subjects
Health Care Administration
Journal Section
Research Article
Authors
Meral Mert
Türkiye
Yasemin Şefika Akdeniz
*
This is me
Türkiye
Hamide Pişkinpaşa
This is me
Türkiye
Özlem Sevgillioğlu Polat
Türkiye
Göktürk Öğredici
This is me
Türkiye
İşıl Tevetoğlu
This is me
Türkiye
Ayşe Esen
This is me
Türkiye
Evin Bozkur
This is me
Türkiye
Sema Çiftçi Doğanşen
This is me
Türkiye
Yıldız Okuturlar
Türkiye
Publication Date
December 28, 2018
Submission Date
November 14, 2018
Acceptance Date
December 28, 2018
Published in Issue
Year 2018 Volume: 2 Number: 3