Hashimoto Tiroiditli Olgularda TEKHARF Puanlama Sistemine Göre Kardiyovasküler Hastalık Risk Durumu

Abstract

Amaç: Bu çalışmada,  Hashimoto tiroidit olgularında tiroid fonksiyonları ile kardiyovasküler hastalık (KVH) riski arasındaki ilişkinin araştırılması amaçlanmıştır. 

Gereç ve Yöntemler: Ağustos ve Ekim 2018 tarihleri arasında Bülent Ecevit Üniversitesi Tıp Fakültesi Hastanesi İç Hastalıkları kliniğince Hashimoto tiroidit tanısıyla levotiroksin tedavisi altında takip edilmiş olan 69 hasta retrospektif olarak kalp ve damar hastalığı etiyolojik risk faktörleri ve tiroid fonksiyon değerleri açısından incelendi. Tiroid cerrahisi ve malignite öyküsü olanlar çalışmaya dahil edilmedi. KVH risk durumu TEKHARF puanlama sistemine göre düşük, orta ve yüksek risk olarak belirlendi. Olgular serum tiroid bezini uyarıcı hormon (TSH) düzeylerine göre: TSH <2,5mIU/L ve üzeri olmak üzere iki grup olarak tanımlandı. TSH düzeyleri ile KVH risk durumu arasındaki ilişki analiz edildi.

Bulgular: Çalışmaya katılanların %87’si kadındı ve olguların yaş ortalaması 42,71±14,15 yıl idi. TEKHARF puanlama cetveline göre katılımcıların %65,2’si düşük, %21,7’si orta, ve %13’ü ise yüksek risk grubunda yer aldı. Serum TSH düzeyleri ile KVH risk puanları arasında korelasyon saptanmadı (p=0,420; r=0,099). TSH <2,5mIU/L olanlarda serum trigliserid düzeyleri anlamlı derecede düşük bulundu. Bununla birlikte serum LDLve HDL-kolesterol düzeyleri ile anlamlı bir ilişki yoktu (sırasıyla; p=0,685 ve p=0,247).

Sonuç: Hashimoto tiroidit olgularında tiroid fonksiyonları için tedavi hedef değerlerine ulaşılması, KVH riskinin azaltılmasına katkı sağlayabilir.    

Keywords

• Kardiovasküler hastalık riski,TEKHARF,Hashimoto tiroidi

Cardiovascular Disease Risk of Hashimoto Thyroiditis Patients According to the TEKHARF Points System

Abstract

Aim: In this study, we aimed to assess the association between thyroid functions and cardiovascular disease (CVD) risk in patients with Hashimoto thyroiditis over TEKHARF points system. 

Material and Methods: From August to October 2018, 69 patients attending Bülent Ecevit University Faculty of Medicine Hospital Internal diseases clinic with Hashimoto thyroiditis diagnosis receiving levothyroxine treatment were retrospectively investigated in terms of cardiovascular disease etiologic risk factors and thyroid function values. Those with thyroid surgery and malignancy history were not included in the study. CVD risk status was determined as low, moderate and high according to the TEKHARF points system. According to serum thyroid gland stimulating hormone (TSH) levels, two groups were defined as those <2.5 mIU/L TSH and those above. The correlation between TSH levels and CVD risk status was analyzed.

Results: Of those participating in the study 87% were female and the mean age of patients was 42.71±14.15 years. According to the TEKHARF points scale, 65.2% of participants were in the low risk group, 21.7% were in the moderate risk group and 13% were in the high risk group. There was no correlation identified between serum TSH levels and CVD risk points (p=0.420; r=0.099). The serum triglyceride levels of those with TSH <2.5 mIU/L were found to be significantly low. Additionally, there was no significant correlation between serum LDL and HDL cholesterol levels (p=0.685 and p=0.247, respectively).

Conclusion: Achieving target TSH levels in Hashimoto thyroiditis patients may contribute to reducing the CVD risk.

Keywords

• Cardiovascular disease risk,TEKHARF,Hashimoto thyroiditis

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