The COVID-19 and Hypertension

Abstract

On 31 December 2019, a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was detected in China, caused COVID-19 infection and a pandemic. Hypertension (HT) appeared as an important comorbidity affecting prognosis in COVID-19 infection. SARSCoV-2’s use of angiotensin converting enzyme 2 (‘angiotensin converting enzyme-2’, ACE2) as viral entry receptor in the lung has caused concern in patients diagnosed with hypertension and receiving ACEI / ARB therapy in COVID-19 infection. Studies show that the disease is more serious and more mortal in HT patients diagnosed with COVID-19. Taking ACEI / ARB, does not differ prognosis and mortality in many studies and even has positive effects in some studies. In addition, it seems that other antihypertensive treatments do not make a significant difference in terms of prognosis or mortality. Blood pressure of hypertensive patients must be kept under control. If there is no other reason, antihypertensive treatments of patients should not be changed.

Keywords

• COVID-19
• Hypertension,
• Prognosis
• Mortality

COVID-19 ve Hipertansiyon

Abstract

Çin’de, ilk kez 31 Aralık 2019’da, yeni bir ciddi akut solunum sendromu koronavirüs 2 (SARS-CoV-2)’nin neden olduğu COVID-19 enfeksiyonu tespit edildi ve pandemiye sebep oldu. Hipertansiyon (HT), COVID-19 enfeksiyonunda prognozu etkileyen önemli bir komorbidite olarak karşımıza çıkmaktadır. SARS-CoV-2’nin akciğerde viral giriş reseptörü olarak anjiyotensin dönüştürücü enzim 2’yi (‘angiotensin converting enzyme-2’, ACE2) kullanması, COVID-19 enfeksiyonunda hipertansiyon tanısı olan ve ACEI/ARB tedavisi alan hastalar açısından endişe yaratmıştır. Yapılan çalışmalarda HT tanısı olan COVID-19 hastalarında hastalığın daha ciddi ve daha mortal seyrettiği görülmektedir. ACEI/ARB kullanım gruplarında birçok çalışmada prognoz açısından farklılık oluşturmadığı hatta bazı çalışmalarda olumlu etki oluşturduğu izlenmektedir. Ayrıca diğer antihipertansif tedavilerin de prognoz veya mortalite açısından anlamlı farklılık yaratmadığı görülmektedir. Hipertansif hastaların kan basıncı mutlaka kontrol altında tutulmalıdır. Başka bir neden yoksa hastaların antihipertansif tedavileri değiştirilmemelidir.

Keywords

• hipertansiyon
• covid 19
• Prognoz
• Mortalite

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